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T74356PROTAC SOS1 degrader-2；化合物 PROTAC SOS1 degrader-2PROTAC SOS1 degrader-2
PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
价 格：￥电议型 号：T74356产 地：中国大陆
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T74138PROTAC Bcl-xL degrader-2；化合物 PROTAC Bcl-xL degrader-2PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.
价 格：￥电议型 号：T74138产 地：中国大陆
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T74062PROTAC IRAK4 degrader-2；化合物 PROTAC IRAK4 degrader-2PROTAC IRAK4 degrader-2
PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels with a DC50 of 36 nM in the same cell type and inhibits several cytokines in PBMCs [1].
价 格：￥电议型 号：T74062产 地：中国大陆
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T73868PROTAC BTK Degrader-2；化合物 PROTAC BTK Degrader-2PROTAC BTK Degrader-2
PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].
价 格：￥电议型 号：T73868产 地：中国大陆
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T39727ERα degrader-2；ERα降解剂2ERα degrader-2
ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prevention and treatment of HER-positive breast cancer.
价 格：￥电议型 号：T39727产 地：中国大陆
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T18632PROTAC MDM2 Degrader-2；化合物 T18632PROTAC MDM2 Degrader-2
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, this compound facilitates the degradation of MDM2[1].
价 格：￥电议型 号：T18632产 地：中国大陆
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T18609PROTAC ERRα Degrader-2；化合物 T18609PROTAC ERRα Degrader-2
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].
价 格：￥电议型 号：T18609产 地：中国大陆
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T18606PROTAC ER Degrader-2；化合物 T18606PROTAC ER Degrader-2
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, exhibits a greater capability to degrade estrogen receptor-alpha (ERα) compared to PROTAC (without the presence of an antibody)[1].
价 格：￥电议型 号：T18606产 地：中国大陆
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T18605PROTAC ERα Degrader-2；化合物 T18605PROTAC ERα Degrader-2
PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
价 格：￥电议型 号：T18605产 地：中国大陆
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T17728PROTAC CDK9 degrader-2；化合物 T17728PROTAC CDK9 degrader-2
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
价 格：￥电议型 号：T17728产 地：中国大陆
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T13846PROTAC RIPK degrader-2；化合物 T13846PROTAC RIPK degrader-2
PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
价 格：￥电议型 号：T13846产 地：中国大陆
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T13837PROTAC CRABP-II Degrader-2；化合物 T13837PROTAC CRABP-II Degrader-2
PROTAC CRABP-II Degrader-2 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.
价 格：￥电议型 号：T13837产 地：中国大陆
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T13834PROTAC BRD4 Degrader-2；化合物 T13834PROTAC BRD4 Degrader-2
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
价 格：￥电议型 号：T13834产 地：中国大陆
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T12559PROTAC BET degrader-2；化合物 T12559PROTAC BET degrader-2
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
价 格：￥电议型 号：T12559产 地：中国大陆
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T12554PROTAC EED degrader-2；化合物 T12554PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
价 格：￥电议型 号：T12554产 地：中国大陆
