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  • T35987CAY10563；CAY10563CAY10563；CAY10563

    S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10563 is a member of a new class of S-nitrosothiol species that act as an NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.

    价 格：￥电议型 号：T35987产 地：中国大陆

  • T35986CAY10512CAY10512CAY10512|||CAY-10512

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activatio

    价 格：￥电议型 号：T35986产 地：中国大陆

  • T35985CAY10487CAY10487CAY-10487|||CAY10487

    The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits.

    价 格：￥电议型 号：T35985产 地：中国大陆

  • T35984CAY10485；CAY10485CAY10485

    Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.

    价 格：￥电议型 号：T35984产 地：中国大陆

  • T35822CAY10722CAY10722CAY-10722|||CAY10722

    CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patie

    价 格：￥电议型 号：T35822产 地：中国大陆

  • T35821CAY10721；CAY10721CAY10721

    CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.

    价 格：￥电议型 号：T35821产 地：中国大陆

  • T35820CAY10685CAY10685CAY10685|||CAY-10685

    CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety for use in click chemistry reactions. Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.

    价 格：￥电议型 号：T35820产 地：中国大陆

  • T35819CAY10677CAY10677CAY10677|||CAY-10677

    CAY10677 has a wide range of applications in life science related research.

    价 格：￥电议型 号：T35819产 地：中国大陆

  • T35818CAY10669；CAY10669CAY10669

    CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY10669 can dose-dependently inhibit histone H4 acetylation in HepG2 cells in vitro.

    价 格：￥电议型 号：T35818产 地：中国大陆

  • T35813CAY10592CAY10592CAY-10592|||CAY 10592|||CAY10592

    Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM)

    价 格：￥电议型 号：T35813产 地：中国大陆

  • T35812CAY10591；CAY10591CAY10591；CAY10591

    Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This com

    价 格：￥电议型 号：T35812产 地：中国大陆

  • T35811CAY10410；CAY10410CAY10410

    CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reactio

    价 格：￥电议型 号：T35811产 地：中国大陆

  • T35114WAY-123398 free base；化合物 T35114Way-123398|||Way 123398|||Way 123,398|||Way123398|||Way-123,398|||Way

    Way 123398 is a class III antiarrhythmic agent.

    价 格：￥电议型 号：T35114产 地：中国大陆

  • T35113WAY 150138；化合物 T35113WAY150138|||WAY-150138；WAY150138|||WAY-150138

    WAY 150138 inhibits the herpes simplex virus.

    价 格：￥电议型 号：T35113产 地：中国大陆

  • T35112WAY 126299A；化合物 T35112WAY126299A|||WAY-126299A；WAY126299A|||WAY-126299A

    Way 126299a is a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist.

    价 格：￥电议型 号：T35112产 地：中国大陆

  • T35111Way 125971；化合物 T35111Way-125971|||Way125971；Way-125971|||Way125971

    Way 125971 is a bioactive chemcial.

    价 格：￥电议型 号：T35111产 地：中国大陆

  • T35110Way 123783；化合物 T35110Way-123783|||Way123783；Way-123783|||Way123783

    Way 123783 is a bioactive chemical.

    价 格：￥电议型 号：T35110产 地：中国大陆

  • T35109Way 123223；化合物 T35109Way123223|||Way-123223；Way123223|||Way-123223

    Way 123223 is a bioactive chemical.

    价 格：￥电议型 号：T35109产 地：中国大陆

  • T35108Way 120744；化合物 T35108Way120744|||Way-120744；Way120744|||Way-120744

    Way 120744 is a new naphthyl 3h -1,2,3,5-oxadiazole 2-oxide.

    价 格：￥电议型 号：T35108产 地：中国大陆

  • T35107Way 120491；化合物 T35107Way120491|||Way-120,491|||Way-120491|||Celikalim；Way120491|||Way-120,491|||Way-

    Way 120491 activates ATP-sensitive potassium channels.

    价 格：￥电议型 号：T35107产 地：中国大陆

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