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  • T70588Tazemetostat HCl；化合物 Tazemetostat HClTazemetostat HCl

    Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1

    价 格：￥电议型 号：T70588产 地：中国大陆

  • T70585Cyclazosin HCl；化合物 Cyclazosin HClCyclazosin HCl

    Cyclazosin HCl is a hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride. It has a role as an alpha1B-adrenoceptor antagonist. It contains a cyclazosin.

    价 格：￥电议型 号：T70585产 地：中国大陆

  • T70522FK-906 HCl；化合物 FK-906 HClFK-906 HCl

    FK-906 HCl is a human renin inhibitor used for the long-term treatment of patients with essential hypertension.

    价 格：￥电议型 号：T70522产 地：中国大陆

  • T70506Bupranolol HCl；化合物 Bupranolol HClBupranolol HCl

    Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 ?g/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]be

    价 格：￥电议型 号：T70506产 地：中国大陆

  • T70489Enerisant HCl；盐酸EnerisantEnerisant HCl

    Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.

    价 格：￥电议型 号：T70489产 地：中国大陆

  • T70472Filgotinib HCl hydrate；化合物 Filgotinib HCl hydrateFilgotinib HCl hydrate

    Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn´s disease.

    价 格：￥电议型 号：T70472产 地：中国大陆

  • T70446Abivertinib HCl；化合物 Abivertinib HClAbivertinib HCl

    Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML. Abivertinib may be a promising novel agent for A

    价 格：￥电议型 号：T70446产 地：中国大陆

  • T70444Edicotinib HCl；化合物 Edicotinib HClEdicotinib HCl

    Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tum

    价 格：￥电议型 号：T70444产 地：中国大陆

  • T70411PS372424 HCl；化合物 PS372424 HClPS372424 HCl

    PS372424 is a specific agonist of human CXCR3. It has been shown to induce phosphorylation of ERK and block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice.

    价 格：￥电议型 号：T70411产 地：中国大陆

  • T70394Deucravacitinib HCl；化合物 Deucravacitinib HClDeucravacitinib HCl

    Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp

    价 格：￥电议型 号：T70394产 地：中国大陆

  • T70391AMG151 HCl；化合物 AMG151 HClAMG151 HCl

    ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse

    价 格：￥电议型 号：T70391产 地：中国大陆

  • T70385CGS-27023A HCl；化合物 CGS-27023A HClCGS-27023A HCl

    CGS-27023A is a novel matrix metalloproteinase inhibitor.

    价 格：￥电议型 号：T70385产 地：中国大陆

  • T70382KBP-7018 HCl；化合物 KBP-7018 HClKBP-7018 HCl

    KBP-7018 Hydrochloride is a novel, tyrosine kinase-selective inhibitor with potent effects on three fibrotic kinases (c-KIT, PDGFR, and RET).

    价 格：￥电议型 号：T70382产 地：中国大陆

  • T70377BAY 61-3606 HCl；化合物 BAY 61-3606 HClBAY 61-3606 HCl

    BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used i

    价 格：￥电议型 号：T70377产 地：中国大陆

  • T70304CI-898 HCl；化合物 CI-898 HClCI-898 HCl

    CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.

    价 格：￥电议型 号：T70304产 地：中国大陆

  • T70295MDL-105212A HCl；化合物 MDL-105212A HClMDL-105212A HCl

    MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist.

    价 格：￥电议型 号：T70295产 地：中国大陆

  • T70293KAA-276 HCl；化合物 KAA-276 HClKAA-276 HCl

    KAA-276 HCl is the salt form of KAA-276 free base, a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.

    价 格：￥电议型 号：T70293产 地：中国大陆

  • T70292DDPM-2571 HCl；化合物 DDPM-2571 HClDDPM-2571 HCl

    DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and was highly effective in the prevention of chemically-induced seizures (pentylenetetrazole and pilocarpine models) and 6-Hz convulsions. It demonstrated significant anxiolytic-like and antidepressant-like properties. DDPM-2571 had antinociceptive properties, both in the hot plate

    价 格：￥电议型 号：T70292产 地：中国大陆

  • T70273APTO-253 HCl；化合物 APTO-253 HClAPTO-253 HCl

    APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor

    价 格：￥电议型 号：T70273产 地：中国大陆

  • T70267ADL 08-0011 HCl；化合物 ADL 08-0011 HClADL 08-0011 HCl

    ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverse

    价 格：￥电议型 号：T70267产 地：中国大陆

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