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T16999Tavapadon;化合物TavapadonPF-6649751|||CVL-751;PF-6649751|||CVL-751
Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
价 格:¥电议型 号:T16999产 地:中国大陆
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T16988Taprenepag isopropyl;化合物 T16988PF-04217329;PF-04217329
Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
价 格:¥电议型 号:T16988产 地:中国大陆
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T16845Sarolaner;化合物SarolanerPF-6450567;PF-6450567
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).
价 格:¥电议型 号:T16845产 地:中国大陆
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T1661LCrizotinib acetate;化合物 T1661LPF02341066|||PF-2341066|||PF 02341066|||PF-02341066|||PF2341066;PF02341
Crizotinib, an orally bioavailable agent, belongs to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity.
价 格:¥电议型 号:T1661L产 地:中国大陆
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T1661Crizotinib克唑替尼PF-02341066|||克唑替尼
Crizotinib (PF-02341066) is a small molecule tyrosine kinase inhibitor that inhibits c-MET and ALK receptors (IC50=8/20 nM), is ATP-competitive, and also inhibits ROS1. Crizotinib exhibits antitumor activity and inhibits tumor growth.
价 格:¥电议型 号:T1661产 地:中国大陆
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T16591Propargyl-PEG1-SS-PEG1-PFP ester;化合物 T16591Propargyl-PEG1-SS-PEG1-PFP ester
Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable linker consisting of a 1-unit polyethylene glycol (PEG) backbone, designed for use in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T16591产 地:中国大陆
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T16515PF 750;化合物PF 750PF-750|||UNII-7756CPP14K|||ZINC27647189;PF-750|||UNII-7756CPP14K|||ZINC27647189
PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.
价 格:¥电议型 号:T16515产 地:中国大陆
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T16514PF 04531083;化合物PF 04531083PF 04531083
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.
价 格:¥电议型 号:T16514产 地:中国大陆
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T16513PF 03709270;化合物 T16513ulopenem etzadroxil;ulopenem etzadroxil
PF 03709270 is an orally available ester prodrug form of sulopenem. It has broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.
价 格:¥电议型 号:T16513产 地:中国大陆
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T16512PFE-360;化合物PFE-360PF-06685360;PF-06685360
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
价 格:¥电议型 号:T16512产 地:中国大陆
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T16511PF2562;化合物 T16511PF2562
PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity against human D1 cAMP (EC50: 568 nM in HTRF assay).
价 格:¥电议型 号:T16511产 地:中国大陆
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T16510PF-915275;化合物PF-915275PF-915275
PF-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
价 格:¥电议型 号:T16510产 地:中国大陆
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T16508PF-5190457;化合物PF-5190457PF-05190457;PF-05190457
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
价 格:¥电议型 号:T16508产 地:中国大陆
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T16507PF-5006739;化合物 T16507PF-5006739
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent m
价 格:¥电议型 号:T16507产 地:中国大陆
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T16506PF-4878691;化合物PF-48786913M-852A;3M-852A
PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
价 格:¥电议型 号:T16506产 地:中国大陆
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T16505PF-4778574;化合物 T16505PF-4778574
PF-4778574 is a positive AMPA receptor allosteric modulation (EC50: 45 to 919 nM in different cells).
价 格:¥电议型 号:T16505产 地:中国大陆
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T16504PF-4693627;化合物 T16504PF-4693627
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
价 格:¥电议型 号:T16504产 地:中国大陆
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T16503PF-4191834;化合物PF-4191834PF-04191834;PF-04191834
PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-4191834
价 格:¥电议型 号:T16503产 地:中国大陆
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T16502PF-3882845;化合物 T16502PF-3882845
PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy.
价 格:¥电议型 号:T16502产 地:中国大陆
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T16501PF-3644022;化合物PF-3644022PF-3644022
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively).
价 格:¥电议型 号:T16501产 地:中国大陆