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  • T60788Carboxylesterase-IN-3；化合物Carboxylesterase-IN-3Carboxylesterase-IN-3

    Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.

    价 格：￥电议型 号：T60788产 地：中国大陆

  • T60770PqsR/LasR-IN-3；化合物 PqsR/LasR-IN-3PqsR/LasR-IN-3

    PqsR/LasR-IN-3 (Compound 7a) inhibits hERG with the IC 50 of 109.01 μM which is also a PqsR and LasR systems inhibitor in P. aeruginosa [1].

    价 格：￥电议型 号：T60770产 地：中国大陆

  • T60758Tubulin polymerization-IN-36；化合物 Tubulin polymerization-IN-36Tubulin polymerization-IN-36

    Tubulin polymerization-IN-36 is able to be used in cancer research, for example, lymphomas. Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding, that is an inhibitor of tubulin polymerization with IC50 of 2.8 μΜ[1].

    价 格：￥电议型 号：T60758产 地：中国大陆

  • T60631SIRT1-IN-3；化合物 SIRT1-IN-3SIRT1-IN-3

    SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].

    价 格：￥电议型 号：T60631产 地：中国大陆

  • T60529AChE/BChE-IN-3；化合物 AChE/BChE-IN-3AChE/BChE-IN-3

    AChE/BChE-IN-3 (BMC-1) is an AChE and BChE dual inhibitor with IC 50 values of 6.08 μM for electric eel AChE (elAChE) and 0.383 μM for equine serum BChE (eqBChE), respectively [1].

    价 格：￥电议型 号：T60529产 地：中国大陆

  • T60527PDHK-IN-3；化合物 PDHK-IN-3PDHK-IN-3

    PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].

    价 格：￥电议型 号：T60527产 地：中国大陆

  • T60520Cas9-IN-3；化合物 Cas9-IN-3Cas9-IN-3

    Cas9-IN-3 is a potent inhibitor of Cas9 with IC50 of 28 μM. CRISPR/Cas systems have revolutionized gene editing in several species [1].

    价 格：￥电议型 号：T60520产 地：中国大陆

  • T60512Haspin-IN-3；化合物Haspin-IN-3Haspin-IN-3

    Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.

    价 格：￥电议型 号：T60512产 地：中国大陆

  • T60506Vps34-IN-3；化合物 Vps34-IN-3Vps34-IN-3

    Vps34-IN-3 is a potent, selective, and orally bioavailable inhibitor of VPS34 kinase .

    价 格：￥电议型 号：T60506产 地：中国大陆

  • T60453TrxR-IN-3；化合物 TrxR-IN-3TrxR-IN-3

    TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and leads to significant apoptosis by regulating the expression of apoptosis-related proteins in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and reducing the expression of LC3-I a

    价 格：￥电议型 号：T60453产 地：中国大陆

  • T60442NLRP3/AIM2-IN-3；化合物NLRP3/AIM2-IN-3NLRP3/AIM2-IN-3

    NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3

    价 格：￥电议型 号：T60442产 地：中国大陆

  • T60432NAAA-IN-3；化合物 NAAA-IN-3NAAA-IN-3

    NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). PEA is an endogenous agonist of the nuclear peroxisome proliferator-activated receptor-α (PPAR-α), which is a key regulator of inflammation and pain. The potential role of NAAA-IN-3 is as a therapeutic agent for the treatment of inflammation and pain.

    价 格：￥电议型 号：T60432产 地：中国大陆

  • T60309PARP10/15-IN-3；化合物 PARP10/15-IN-3PARP10/15-IN-3

    PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC 50 values of 0.14 μM and 0.40 μM against PARP10 and PARP15, respectively. PARP10/15-IN-3 can enter cells and rescue cells from apoptosis [1].

    价 格：￥电议型 号：T60309产 地：中国大陆

  • T60282Metallo-β-lactamase-IN-3；化合物 Metallo-β-lactamase-IN-3Metallo-β-lactamase-IN-3

    Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor that has the potential to restore the activity of current β-lactam antibiotics and to offer an orthogonal strategy to the discovery of new antibiotics. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC 50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 [1].

    价 格：￥电议型 号：T60282产 地：中国大陆

  • T60257SIRT-IN-3；化合物 SIRT-IN-3SIRT-IN-3

    SIRT-IN-3, a potent inhibitor of SIRT1 with an IC50 value of 17 μM, exhibits approximate 4-fold and 14-fold greater selectivity for SIRT1 over SIRT2 and SIRT3, with respective IC50 values of 74 μM for SIRT2 and 235 μM for SIRT3 [1].

    价 格：￥电议型 号：T60257产 地：中国大陆

  • T6023Nutlin-3a；化合物Nutlin-3a(-)-Nutlin-3|||Nutlin-3a chiral|||(?)-Nutlin-3；(-)-Nutlin-3|||Nutlin-3a chiral

    Nutlin-3a ((?)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.

    价 格：￥电议型 号：T6023产 地：中国大陆

  • T60219ELOVL1-IN-3u00A0；化合物ELOVL1-IN-3ELOVL1-IN-3u00A0

    ELOVL1-IN-3 is a potent and orally active inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. ELOVL1-IN-3 serves as a useful tool for researching adrenoleukodystrophy (ALD).

    价 格：￥电议型 号：T60219产 地：中国大陆

  • T60185FGFR2-IN-3；化合物FGFR2-IN-3FGFR2-IN-3

    FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].

    价 格：￥电议型 号：T60185产 地：中国大陆

  • T60158PBRM1-BD2-IN-3；化合物PBRM1-BD2-IN-3PBRM1-BD2-IN-3

    PBRM1-BD2-IN-3 (compound 12) is a potent inhibitor of PBRM1-BD2, exhibiting an IC50 value of 1.1 μM, and is utilized in anticancer research.

    价 格：￥电议型 号：T60158产 地：中国大陆

  • T601186,7-Dihydro-2H-cyclopenta[c]pyridazin-3(5H)-one；6,7-二氢-2H-环戊烷并[C]哒嗪-3(5H)-酮6,7-Dihydro-5H-cyclopenta

    6,7-Dihydro-2H-cyclopenta[c]pyridazin-3(5H)-one (2H,3H,5H,6H,7H-cyclopenta[c]pyridazin-3-one) is an intermediate used to synthesize Pyridazine derivatives

    价 格：￥电议型 号：T60118产 地：中国大陆

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