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  • T71106Cotosudil 2HCl;化合物 Cotosudil 2HClCotosudil 2HCl

    Cotosudil 2HCl is the salt form of Cotosudil Free Base, a Rho-associated (ROCK) kinase inhibitor.

    价 格:¥电议型 号:T71106产 地:中国大陆

  • T71104HSR-175 HCl;化合物 HSR-175 HClHSR-175 HCl

    HSR-175 HCl is an alpha 1-adrenoceptor antagonist.

    价 格:¥电议型 号:T71104产 地:中国大陆

  • T71086IT-066 HCl;化合物 IT-066 HClIT-066 HCl

    IT-066 HCl is a histamine H2 receptor antagonist.

    价 格:¥电议型 号:T71086产 地:中国大陆

  • T71070Itasetron HCl;化合物 Itasetron HClItasetron HCl

    Itasetron HCl is a potent 5HT-3 receptor antagonist.

    价 格:¥电议型 号:T71070产 地:中国大陆

  • T71069GSK1842799 HCl;化合物 GSK1842799 HClGSK1842799 HCl

    GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000× selectivity over S1P3. GSK1842799 demonstrated good oral bioavailability. On the basis of the favorable in vitro ADME and in vivo PK/PD properties as well as broad toxicology evaluations, GSK1842799 was selected as a candidate for further clinical.

    价 格:¥电议型 号:T71069产 地:中国大陆

  • T71058Doramapimod HCl;化合物 Doramapimod HClDoramapimod HCl

    Doramapimod HCl is the salt form of Doramapimod, a member of the N-pyrazole-N´-naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and dissociation rates. BIRB -796 has entered clinical trials for the treatment of autoimmune diseases.

    价 格:¥电议型 号:T71058产 地:中国大陆

  • T71045FK-1052 HCl;化合物 FK-1052 HClFK-1052 HCl

    FK-1052 HCl is a serotonin 3 & 4 dual receptor antagonist.

    价 格:¥电议型 号:T71045产 地:中国大陆

  • T71029RCC-36 HCl;化合物 RCC-36 HClRCC-36 HCl

    Rcc 36 is an active metabolite of temiverine that has inhibitory actions toward the atropine-resistant part of contractions, which may be related to the calcium antagonistic actions of these compounds.

    价 格:¥电议型 号:T71029产 地:中国大陆

  • T71026MC2050 HCl;化合物 MC2050 HClMC2050 HCl

    MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

    价 格:¥电议型 号:T71026产 地:中国大陆

  • T70994TAK-659 HCl;化合物 TAK-659 HClTAK-659 HCl

    TAK-659 is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Note: TAK-659 free base is less stable. This product is supplied as dihydrochloride form.

    价 格:¥电议型 号:T70994产 地:中国大陆

  • T70954SP-187 HCl;化合物 SP-187 HClSP-187 HCl

    SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium.

    价 格:¥电议型 号:T70954产 地:中国大陆

  • T70944Carotegrast methyl HCl;化合物 Carotegrast methyl HClCarotegrast methyl HCl

    Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer´s patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.

    价 格:¥电议型 号:T70944产 地:中国大陆

  • T70927UCD74A HCl;化合物 UCD74A HClUCD74A HCl

    UCD74A HCl is a cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator).

    价 格:¥电议型 号:T70927产 地:中国大陆

  • T70901QC-308 HCl;化合物 QC-308 HClQC-308 HCl

    QC-308 HCl is a novel Heme Oxygenase-1 Inhibitor (HO-1 IC50=0.27μM; HO-2 IC50=0.46μM).

    价 格:¥电议型 号:T70901产 地:中国大陆

  • T70897Zotiraciclib HCl;化合物 Zotiraciclib HClZotiraciclib HCl

    Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, w

    价 格:¥电议型 号:T70897产 地:中国大陆

  • T70823Momelotinib HCl;化合物 Momelotinib HClMomelotinib HCl

    Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.

    价 格:¥电议型 号:T70823产 地:中国大陆

  • T70818TC-2153;化合物 TC-2153 HClTC-2153

    TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), exhibiting psychotropic activity and low acute toxicity. This compound not only enhances the expression of brain-derived neurotropic factor (BDNF) in the brain but also reduces the mRNA levels of MAOA and 5-HT1A receptors in the midbrain. Additionally, TC-2153 inhibits 5-HT2A receptor-mediated signaling.

    价 格:¥电议型 号:T70818产 地:中国大陆

  • T70807Lanabecestat HCl;化合物 Lanabecestat HClLanabecestat HCl

    Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ.

    价 格:¥电议型 号:T70807产 地:中国大陆

  • T70788KST012174 HCl;化合物 KST012174 HClKST012174 HCl

    KST012174 is a HIF-1α inhibitor. KST012174 involves in the HIF-1α/p300 protein?protein interaction.

    价 格:¥电议型 号:T70788产 地:中国大陆

  • T70758Copanlisib HCl hydrate;化合物 Copanlisib HCl hydrateCopanlisib HCl hydrate

    Copanlisib Dihydrochloride is a novel phosphoinositide 3-kinase (pi3k) inhibitor, inhibiting the activation of the pi3k signaling pathway, resulting in inhibition of tumor cell growth and survival in susceptible tumor cell populations

    价 格:¥电议型 号:T70758产 地:中国大陆

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