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  • T37847Zonisamide-13C2,15N;Zonisamide-13C2,15NZonisamide-13C2,15N;Zonisamide-13C2,15N

    Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium

    价 格:¥电议型 号:T37847产 地:中国大陆

  • T37608Riluzole-13C,15N2;Riluzole-13C,15N2Riluzole-13C,15N2;Riluzole-13C,15N2

    Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a

    价 格:¥电议型 号:T37608产 地:中国大陆

  • T37250Cefazolin-13C2,15N;Cefazolin-13C2,15NCefazolin-13C2,15N;Cefazolin-13C2,15N

    Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml).

    价 格:¥电议型 号:T37250产 地:中国大陆

  • T371191,2,3-Trioctanoyl-rac-glycerol-13C3;1,2,3-Trioctanoyl-rac-glycerol-13C31,2,3-Trioctanoyl-rac-glycero

    1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomo

    价 格:¥电议型 号:T37119产 地:中国大陆

  • T370441,2-Dioleoyl-rac-glycerol-13C3;1,2-Dioleoyl-rac-glycerol-13C31,2-Dioleoyl-rac-glycerol-13C3;1,2-Diol

    1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3

    价 格:¥电议型 号:T37044产 地:中国大陆

  • T36903Rasagiline-13C3 (mesylate);Rasagiline-13C3 (mesylate)Rasagiline-13C3 (mesylate);Rasagiline-13C3 (mes

    Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede

    价 格:¥电议型 号:T36903产 地:中国大陆

  • T368955-Fluorouracil-13C,15N2;5-Fluorouracil-13C,15N25-Fluorouracil-13C,15N2;5-Fluorouracil-13C,15N2

    5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

    价 格:¥电议型 号:T36895产 地:中国大陆

  • T36660Olsalazine-13C6;Olsalazine-13C6Olsalazine-13C6;Olsalazine-13C6

    Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1

    价 格:¥电议型 号:T36660产 地:中国大陆

  • T36537Nitrofurantoin-13C3;Nitrofurantoin-13C3Nitrofurantoin-13C3;Nitrofurantoin-13C3

    Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1

    价 格:¥电议型 号:T36537产 地:中国大陆

  • T36408Rhein-13C4;Rhein-13C4Rhein-13C4;Rhein-13C4

    Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i

    价 格:¥电议型 号:T36408产 地:中国大陆

  • T36383L-Thyroxine-13C9,15N;L-Thyroxine-13C9,15NL-Thyroxine-13C9,15N;L-Thyroxine-13C9,15N

    L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine.

    价 格:¥电议型 号:T36383产 地:中国大陆

  • T36299Uridine triphosphate 13C9,15N2 sodium;Uridine triphosphate 13C9,15N2 sodiumUridine triphosphate 13C9

    Uridine triphosphate 13C9,15N2 (UTP 13C9,15N2) sodium, a labeled form of uridine triphosphate sodium, facilitates nucleic acid synthesis.

    价 格:¥电议型 号:T36299产 地:中国大陆

  • T3614913C C16 Sphingomyelin (d18:1/16:0);13C C16 Sphingomyelin (d18:1/16:0)13C C16 Sphingomyelin (d18:1/16

    13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or

    价 格:¥电议型 号:T36149产 地:中国大陆

  • T36059Dichlorphenamide-13C6;Dichlorphenamide-13C6Dichlorphenamide-13C6;Dichlorphenamide-13C6

    Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc

    价 格:¥电议型 号:T36059产 地:中国大陆

  • T36055Nitisinone-13C6;Nitisinone-13C6Nitisinone-13C6;Nitisinone-13C6

    Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F

    价 格:¥电议型 号:T36055产 地:中国大陆

  • T36021Flumequine-13C3;Flumequine-13C3Flumequine-13C3;Flumequine-13C3

    Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3

    价 格:¥电议型 号:T36021产 地:中国大陆

  • T35915Erlotinib-13C6;Erlotinib-13C6Erlotinib-13C6;Erlotinib-13C6

    Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

    价 格:¥电议型 号:T35915产 地:中国大陆

  • T35790Palmitic acid-1,2,3,4-13C4;Palmitic Acid-13C (C1, C2, C3, and C4 labeled)Palmitic Acid-13C (C1, C2,

    Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula

    价 格:¥电议型 号:T35790产 地:中国大陆

  • T35789Palmitic acid-1-13C;Palmitic Acid-13C (C1 labeled)Palmitic acid-1-13C

    Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6

    价 格:¥电议型 号:T35789产 地:中国大陆

  • T35783Zearalenone-13C18;Zearalenone-13C18Zearalenone-13C18;Zearalenone-13C18

    Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i

    价 格:¥电议型 号:T35783产 地:中国大陆

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