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  • T83226A3373；化合物 A3373A3373

    A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) of 325 nM for PLD1 and 15.15 μM for PLD2. This compound effectively suppresses lipopolysaccharide (LPS)-induced immune responses and is implicated in key processes of autoimmune arthritis, bone demineralization, and osteoclastogenesis [1] [2].

    价 格：￥电议型 号：T83226产 地：中国大陆

  • T82947Atinumab；化合物 AtinumabATI355|||6A3-IgG4；ATI355|||6A3-IgG4

    Atinumab (6A3-IgG4), an antibody, has potential applications in spinal cord injury (SCI) research [1].

    价 格：￥电议型 号：T82947产 地：中国大陆

  • T80900Unasnemab；化合物 UnasnemabMT-3921|||rH116A3；MT-3921|||rH116A3

    Unasnemab (MT-3921), a humanized IgG1 monoclonal antibody, targets repulsive guidance molecule A (RGMa) to enhance locomotor function and support neuroregeneration, showing potential for spinal cord injury research [1].

    价 格：￥电议型 号：T80900产 地：中国大陆

  • T79373A3AR agonist 2；化合物 A3AR agonist 2A3AR agonist 2

    Compound 19, a selective A3 Adenosine Receptor (A3AR) agonist (K i : 22.1 nM), effectively stimulates β-arrestin2 recruitment with an EC 50 value of 4.36 nM. This compound is utilized in research pertaining to inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions [1].

    价 格：￥电议型 号：T79373产 地：中国大陆

  • T79372A3AR agonist 1；化合物 A3AR agonist 1A3AR agonist 1

    A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effective concentration (EC50) of 5.17 nM. It serves as a research tool in various pathological conditions, including inflammatory diseases, ischemia, cancer, neuropathic pain, and liver diseases [1].

    价 格：￥电议型 号：T79372产 地：中国大陆

  • T79027A1/A3 AR antagonist 3；化合物 A1/A3 AR antagonist 3A1/A3 AR antagonist 3

    A1/A3 AR Antagonist 3 is a dual A1R/A3R antagonist that demonstrates high affinity within the low-micromolar to nanomolar range, and is potentially useful in the research of chronic heart diseases [1].

    价 格：￥电议型 号：T79027产 地：中国大陆

  • T78809NDNA3；化合物 NDNA3NDNA3

    NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 μM and 11.72 μM respectively. It stabilizes hERG channel maturation without eliciting a heat shock response or degrading Hsp90α-dependent client proteins [1].

    价 格：￥电议型 号：T78809产 地：中国大陆

  • T78604SLC26A3-IN-3；化合物 SLC26A3-IN-3SLC26A3-IN-3

    SLC26A3-IN-3 (compound 4az), a potent SLC26A3 inhibitor with an IC50 of 40 nM, is utilized for constipation and cystic fibrosis research [1].

    价 格：￥电议型 号：T78604产 地：中国大陆

  • T785264A3-SC8；化合物 4A3-SC84A3-SC8

    4A3-SC8 is a modular, degradable dendrimer facilitating the extension of survival in aggressive liver cancer models through the delivery of small RNAs [1].

    价 格：￥电议型 号：T78526产 地：中国大陆

  • T78263Anti-Mouse IFNAR1 Antibody (MAR1-5A3)；化合物 Anti-Mouse IFNAR1 Antibody (MAR1-5A3)Anti-Mouse IFNAR1 Ant

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing monoclonal antibody that specifically binds to IFNAR1, blocking its signaling both in vitro and in vivo. It is of the Mouse IgG1 kappa isotype and a corresponding isotype control accompanies the antibody [1] [2].

    价 格：￥电议型 号：T78263产 地：中国大陆

  • T75913[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA；化合物 [cPP1-7,NPY19-23,Ala31,Aib32,Gln

    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent, selective neuropeptide Y Y5 receptor agonist, demonstrating binding affinity with an IC50 of 0.24 nM for the hY5 receptor. This compound significantly stimulates food intake [1].

    价 格：￥电议型 号：T75913产 地：中国大陆

  • T754913-(2-Hydroxyethyl) thio withaferin A；化合物 3-(2-Hydroxyethyl) thio withaferin A3-(2-Hydroxyethyl) thio

    3-(2-Hydroxyethyl) thio withaferin A, a derivative of Withaferin A, is a steroidal lactone that inhibits NF-kB activation and targets vimentin, showcasing potent anti-inflammatory and anticancer properties. It also acts as an inhibitor of endothelial protein C receptor (EPCR) shedding [1] [2] [3].

    价 格：￥电议型 号：T75491产 地：中国大陆

  • T74993A3AR modulator 1；化合物 A3AR modulator 1A3AR modulator 1

    A3AR modulator 1 (MRS8054), an orally active positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) (Adenosine Receptor), significantly enhances the efficacy (E max) of Cl-IB-MECA-stimulated [35 S]GTPγS binding [1].

    价 格：￥电议型 号：T74993产 地：中国大陆

  • T74815SLC26A3-IN-2；化合物 SLC26A3-IN-2SLC26A3-IN-2

    SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, displaying an IC50 of 360 nM. This protein is a member of the solute carrier (SLC) family, specifically the SLC26 family, known for its broad anion specificity, including chloride, bicarbonate, sulfate, and oxalate. SLC26A3, also known as DRA, is typically down-regulated in adenoma and plays a crucial role in the intestinal absorption of chloride and oxalate. Moreover, mutations resul

    价 格：￥电议型 号：T74815产 地：中国大陆

  • T74606A2A/A3u00A0AR antagonist-1；化合物 A2A/A3u00A0AR antagonist-1A2A/A3u00A0AR antagonist-1

    Compound 23, designated as A2A/A3 AR antagonist-1, is a dual fluorescent ligand targeting A2A and A3 adenosine receptors (AR), exhibiting dissociation constants (Ki) of 90 nM for hA2A AR and 31.8 nM for hA3 AR, respectively [1].

    价 格：￥电议型 号：T74606产 地：中国大陆

  • T74445ZA3-Ep10；化合物 ZA3-Ep10ZA3-Ep10

    ZA3-Ep10, a zwitterionic lipid, is utilized in the formulation of lipid nanoparticles for RNA delivery in vivo and non-viral CRISPR/Cas gene editing applications.

    价 格：￥电议型 号：T74445产 地：中国大陆

  • T7395Lanifibranor；化合物LanifibranorIVA337；IVA337

    Lanifibranor (IVA337) is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity

    价 格：￥电议型 号：T7395产 地：中国大陆

  • T73001eIF4A3-IN-9；化合物 eIF4A3-IN-9eIF4A3-IN-9

    eIF4A3-IN-9, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 29, 450, and 80 nM for myc-LUC, tub-LUC, and growth inhibition in MBA-MB-231 cells, respectively. It is utilized in researching human cancer pathogenesis [1].

    价 格：￥电议型 号：T73001产 地：中国大陆

  • T72944eIF4A3-IN-18；化合物 eIF4A3-IN-18eIF4A3-IN-18

    eIF4A3-IN-18, a silvestrol analogue, disrupts the formation of the eIF4F translation complex, exhibiting EC 50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and the growth inhibition of MBA-MB-231 cells, respectively. Additionally, it demonstrates cytotoxicity towards RMPI-8226 cells with an LC 50 of 0.06 nM. This compound is utilized in researching human cancer pathogenesis [1].

    价 格：￥电议型 号：T72944产 地：中国大陆

  • T72943eIF4A3-IN-17；化合物 eIF4A3-IN-17eIF4A3-IN-17

    eIF4A3-IN-17, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 0.9, 15, and 1.8 nM for myc-LUC, tub-LUC, and growth inhibition of MBA-MB-231 cells, respectively. This compound holds potential for research in human cancer pathogenesis [1].

    价 格：￥电议型 号：T72943产 地：中国大陆

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