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T82265GPR3 agonist-2;化合物 GPR3 agonist-2GPR3 agonist-2
GPR3 agonist-2 (compound 32) is a potent full agonist of the G protein-coupled receptor 3 (GPR3), exhibiting an IC50 value of 260 nM [1].
价 格:¥电议型 号:T82265产 地:中国大陆
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T82264GPR34 receptor antagonist 3;化合物 GPR34 receptor antagonist 3GPR34 receptor antagonist 3
Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1/2 phosphorylation in a dose-dependent manner, demonstrating an IC50 value of 0.680 μM without significant cytotoxicity. Additionally, it displays antisensory activity in a mouse neuropathic pain model [1].
价 格:¥电议型 号:T82264产 地:中国大陆
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T82263GPR61 Inverse agonist 1;化合物 GPR61 Inverse agonist 1GPR61 Inverse agonist 1
Compound 1, identified as a GPR61 inverse agonist, exhibits an IC50 of 11 nM, rendering it suitable for metabolism and body weight disorder research, including obesity and cachexia [1].
价 格:¥电议型 号:T82263产 地:中国大陆
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T79902GPR88 agonist 2;化合物 GPR88 agonist 2GPR88 agonist 2
GPR88 agonist 2 (compound 53) serves as a potent, brain-penetrant agonist of GPR88, exhibiting an EC50 of 14 ?M in the GPR88 cAMP functional assay [1].
价 格:¥电议型 号:T79902产 地:中国大陆
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T79901GPR88-IN-1;化合物 GPR88-IN-1GPR88-IN-1
GPR88-IN-1 is a GPR88 antagonist that may be utilized for the study of central nervous system disorders [1].
价 格:¥电议型 号:T79901产 地:中国大陆
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T79744GPR55 agonist 4;化合物 GPR55 agonist 4GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].
价 格:¥电议型 号:T79744产 地:中国大陆
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T79721GPR55 agonist 3;化合物 GPR55 agonist 3GPR55 agonist 3
Compound 26, a GPR55 agonist, exhibits potent activity with EC50 values of 0.239 nM for hGPR55 and 1.76 nM for rGPR55. It also induces β-arrestin recruitment to human GPR55 with an EC50 of 6.2 nM [1].
价 格:¥电议型 号:T79721产 地:中国大陆
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T79475GPR119 agonist 2;化合物 GPR119 agonist 2GPR119 agonist 2
GPR119 agonist 2 (compound 43), an orally active agonist of GPR119, exhibits favorable pharmacokinetic properties in rodents and has demonstrated efficacy in enhancing glucose tolerance in both mice and rats, indicating its potential in type 2 diabetes research [1].
价 格:¥电议型 号:T79475产 地:中国大陆
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T79209Ogremorphin;化合物 OgremorphinGPR68-IN-1|||OGM;GPR68-IN-1|||OGM
Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1].
价 格:¥电议型 号:T79209产 地:中国大陆
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T78100GPR109 receptor agonist-2;化合物 GPR109 receptor agonist-2GPR109 receptor agonist-2
Compound 5, a selective GPR109a agonist, exhibits a pEC50 value of 5.53 [1].
价 格:¥电议型 号:T78100产 地:中国大陆
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T78078GPR52 receptor modulator 1;化合物 GPR52 receptor modulator 1GPR52 receptor modulator 1
GPR52 receptor modulator 1, a compound delineated as per Procedure 1, is a modulator of the GPR52 receptor, offering research potential in the investigation of neuropsychiatric diseases [1].
价 格:¥电议型 号:T78078产 地:中国大陆
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T76288GPR;化合物 GPRGPR
GPR, a tripeptide, shows promise in Alzheimer´s disease (AD) research by protecting cultured rat hippocampal neurons from amyloid-beta (Aβ)-induced death through the inhibition of caspase-3/p53-dependent apoptosis.
价 格:¥电议型 号:T76288产 地:中国大陆
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T74528DPP-4/GPR119 modulator 1;化合物 DPP-4/GPR119 modulator 1DPP-4/GPR119 modulator 1
DPP-4/GPR119 modulator 1 (Compound 22) is an orally active compound that functions as both a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. It demonstrates a glucose-lowering effect in blood and exhibits moderate inhibition of the hERG channel, with an IC50 value of 4.9 ?M. This compound is applicable in diabetes research [1].
价 格:¥电议型 号:T74528产 地:中国大陆
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T72772GPR81 agonist 2;化合物 GPR81 agonist 2GPR81 agonist 2
GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 ?M for hGPR81 and 0.123 ?M for hGPR109A, respectively.
价 格:¥电议型 号:T72772产 地:中国大陆
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T72755GPR35 agonist 3;化合物 GPR35 agonist 3GPR35 agonist 3
GPR35 agonist 3, a synthetic compound, acts as an agonist for GPR35 with an EC50 value of 1.4 μM and is utilized in researching numerous diseases including gastric cancer, type 2 diabetes, cardiovascular diseases, and disorders of the immune and peripheral nervous systems.
价 格:¥电议型 号:T72755产 地:中国大陆
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T72536GPR84 antagonist 2;化合物 GPR84 antagonist 2GPR84 antagonist 2
GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macrophage chemotaxis following GPR84 activation, highlighting its research potential for ulcerative colitis.
价 格:¥电议型 号:T72536产 地:中国大陆
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T71862GPR120-IN-1;化合物 GPR120-IN-1GPR120-IN-1
GPR120-IN-1 is a novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities against SW480.
价 格:¥电议型 号:T71862产 地:中国大陆
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T67892BTB09089;化合物BTB09089GPR65 agonist (BTB09089);GPR65 agonist (BTB09089)
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
价 格:¥电议型 号:T67892产 地:中国大陆
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T63964DPP-4/GPR119 modulator 2;化合物 DPP-4/GPR119 modulator 2DPP-4/GPR119 modulator 2
DPP-4/GPR119 modulator 2 is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 0.22 μM) and an agonist of GPR119 (EC50: 0.95 μM).
价 格:¥电议型 号:T63964产 地:中国大陆
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T63812MrgprX2 antagonist-8;MrgprX2拮抗剂8MrgprX2 antagonist-8
MrgprX2 antagonist-8 is an MrgprX2 antagonist that can be used to study inflammatory diseases.
价 格:¥电议型 号:T63812产 地:中国大陆