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T4604HC-056456;化合物HC-056456HC 056456|||3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide;HC 056456|||3,4-Bis(2
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) is a CatSper channel modulator.
价 格:¥电议型 号:T4604产 地:中国大陆
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T4494CLOZAPINE N-OXIDE氯氮平N-氧化物氯氮平N-氧化|||氯氮平N-氧化物
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
价 格:¥电议型 号:T4494产 地:中国大陆
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T4462Roflumilast N-oxide;罗氟司特N-氧化物Roflumilast N-oxide
Roflumilast N-oxide is an inhibitor of PDE type 4.
价 格:¥电议型 号:T4462产 地:中国大陆
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T41245Trimethylamine N-oxide;三甲胺N-氧化物Trimethylamine N-oxide
Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging effects of urea.Trimethylamine N-oxide induces inflammation through activation of ROS/NLRP3 inflammasomes, which can induce fibroblast differentiation and cardiac fibrosis.
价 格:¥电议型 号:T41245产 地:中国大陆
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T40706Heliotrine N-oxide;Heliotrine N-oxideHeliotrine N-oxide
Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo.
价 格:¥电议型 号:T40706产 地:中国大陆
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T40519Indicine N-oxide;Indicine N-oxide(+)-Indicine N-oxide|||Indicine N-oxide|||NSC132319;(+)-Indicine N-
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.
价 格:¥电议型 号:T40519产 地:中国大陆
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T40512Echimidine N-oxide;Echimidine N-oxideEchimidine N-oxide
Echimidine N-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (AChE) with an IC50 value of 0.347 mM.
价 格:¥电议型 号:T40512产 地:中国大陆
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T40484Jacobineu00A0N-oxide;千里光碱N-氧化物Jacobineu00A0N-oxide
Jacobine N-oxide is a pyrrolizidine alkaloid compound found in thrips-resistant Senecio hybrids.
价 格:¥电议型 号:T40484产 地:中国大陆
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T38134(S)-O-Desmethyl Venlafaxine N-Oxide;S-O-去甲-文拉法辛N-氧化物(S)-O-Desmethyl Venlafaxine N-Oxide
(S)-O-Desmethyl Venlafaxine N-Oxide, an N-oxide derivative of (S)-O-Desmethyl Venlafaxine, constitutes an active metabolite of the serotonin-norepinephrine reuptake inhibitor (SNRI) class antidepressant, Venlafaxine[1][2].
价 格:¥电议型 号:T38134产 地:中国大陆
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T38003Levofloxacin N-oxide;左氧氟沙星N-氧化物Levofloxacin N-oxide
Levofloxacin N-oxide is an impurity isolated from levofloxacin.
价 格:¥电议型 号:T38003产 地:中国大陆
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T37796Voriconazole N-oxide;Voriconazole N-oxideVoriconazole N-oxide
Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.
价 格:¥电议型 号:T37796产 地:中国大陆
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T37643Propiverine N-oxide (hydrochloride);Propiverine N-oxide (hydrochloride)Propiverine N-oxide (hydrochl
Propiverine N-oxide (hydrochloride) is the major metabolite of propiverine in human plasma or urine.
价 格:¥电议型 号:T37643产 地:中国大陆
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T37600Dasatinib N-oxide;达沙替尼N氧化物Dasatinib N-oxide
Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib.It is also a potential impurity in commercial preparations of dasatinib[1][2].
价 格:¥电议型 号:T37600产 地:中国大陆
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T37430Mirtazapine N-oxide;Mirtazapine N-oxideMirtazapine N-oxide
Mirtazapine N-oxide is a metabolite of mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 in human liver microsomes.
价 格:¥电议型 号:T37430产 地:中国大陆
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T37246Palonosetron N-oxide;Palonosetron N-oxidePalonosetron N-oxide
Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress.
价 格:¥电议型 号:T37246产 地:中国大陆
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T36795Donepezil N-oxide;Donepezil N-oxideDonepezil N-oxide
Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil . Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 μM.
价 格:¥电议型 号:T36795产 地:中国大陆
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T36681Sorafenib N-oxide;Sorafenib N-oxideSorafenib N-oxide
Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibi
价 格:¥电议型 号:T36681产 地:中国大陆
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T35882Rizatriptan N-oxide;Rizatriptan N-oxideRizatriptan N-oxide
Rizatriptan N-oxide is a potential impurity found in commercial preparations of rizatriptan.1It is a degradation product formed under oxidative conditions.
价 格:¥电议型 号:T35882产 地:中国大陆
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T32918Lucanthone N-oxide monomethanesulfonate;化合物 T32918Lucanthone N-oxide monomethanesulfonate
Lucanthone N-oxide monomethanesulfonate is a bioactive chemical.
价 格:¥电议型 号:T32918产 地:中国大陆
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T32917Lucanthone N-oxide;化合物 T32917Lucanthone N-oxide
Lucanthone N-oxide is a bioactive chemical.
价 格:¥电议型 号:T32917产 地:中国大陆