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T18616NH2-C2-NH-BocNH2-C2-NH-Boc,PROTAC Linker 22,
NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1].
价 格：￥电议型 号：T18616产 地：美洲
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T18617NH2-C5-NH-BocNH2-C5-NH-Boc,PROTAC Linker 23,
NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1].
价 格：￥电议型 号：T18617产 地：美洲
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T5437Gefitinib-based PROTAC 3Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].
价 格：￥电议型 号：T5437产 地：美洲
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T5835PROTAC ERRα ligand 2PROTAC ERRα ligand 2
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
价 格：￥电议型 号：T5835产 地：美洲
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T8745PROTAC BRAF-V600E degrader-1；化合物2417296-84-3Compound 23；Compound 23
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
价 格：￥电议型 号：T8745产 地：中国大陆
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T8744PROTAC BRAF-V600E degrader-2；化合物 T8744PROTAC BRAF-V600E degrader-2
PROTAC BRAF-V600E degrader-2 is a useful organic compound for research related to life sciences. The catalog number is T8744 and the CAS number is 2417296-82-1.
价 格：￥电议型 号：T8744产 地：中国大陆
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T83857Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting
Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = 0.8 nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphoryla
价 格：￥电议型 号：T83857产 地：中国大陆
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T82809BT-PROTAC；化合物 BT-PROTACBT-PROTAC
BT-PROTAC is a bioorthogonally activatable prodrug that enables precise control over PROTAC (PROteolysis TArgeting Chimera) activity.
价 格：￥电议型 号：T82809产 地：中国大陆
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T82610DA-PROTAC；化合物 DA-PROTACDA-PROTAC
DA-PROTAC is a potent degrader of the copper ion-transport proteins Atox1 and CCS, capable of binding to both proteins and facilitating their association with E3 ligase. This interaction enhances the ubiquitination and subsequent proteasomal degradation of Atox1 and CCS. DA-PROTAC is utilized in triple negative breast cancer research [1].
价 格：￥电议型 号：T82610产 地：中国大陆
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T81386PROTAC BRD4 Degrader-22；化合物 PROTAC BRD4 Degrader-22PROTAC BRD4 Degrader-22
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, exhibiting a pDC50 of 9.2 in MOLT4 cells over 24 hours [1].
价 格：￥电议型 号：T81386产 地：中国大陆
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T81385PROTAC BRD9 Degrader-2；化合物 PROTAC BRD9 Degrader-2PROTAC BRD9 Degrader-2
PROTAC BRD9 Degrader-2 is a bifunctional compound designed for the targeted degradation of BRD9 in cancer research applications.
价 格：￥电议型 号：T81385产 地：中国大陆
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T81384PROTAC BRD9 Degrader-3；化合物 PROTAC BRD9 Degrader-3PROTAC BRD9 Degrader-3
PROTAC BRD9 Degrader-3 is a bifunctional degrader targeting BRD9, utilized in cancer research.
价 格：￥电议型 号：T81384产 地：中国大陆
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T81383PROTAC BRD9 Degrader-5；化合物 PROTAC BRD9 Degrader-5PROTAC BRD9 Degrader-5
PROTAC BRD9 Degrader-5 is a proteolysis targeting chimera (PROTAC) designed for the specific degradation of Bromodomain-containing protein 9 (BRD9).
价 格：￥电议型 号：T81383产 地：中国大陆
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T81382PROTAC BRD9 Degrader-7；化合物 PROTAC BRD9 Degrader-7PROTAC BRD9 Degrader-7
PROTAC BRD9 Degrader-7 is a selective and orally active BRD9 degrader with a DC50 of 1.02 nM and demonstrates superior pharmacokinetics, evidenced by a Cmax of 3436.95 ng/mL [1].
价 格：￥电议型 号：T81382产 地：中国大陆
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T81381PROTAC eDHFR Degrader-1；化合物 PROTAC eDHFR Degrader-1PROTAC eDHFR Degrader-1
PROTAC eDHFR Degrader-1 is a potent degrader targeting eDHFR-YFP and various proteins of interest (POIs), such as YFP and Luciferase [1].
价 格：￥电议型 号：T81381产 地：中国大陆
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T81380PROTAC EGFR degrader 7 diTFA；化合物 PROTAC EGFR degrader 7 diTFAPROTAC EGFR degrader 7 diTFA
PROTAC EGFR degrader 7 (compound 13b) is a potent, selective, CRBN-recruiting EGFRL858R/T790M degrader with a DC50 of 13.2 nM. It effectively inhibits proliferation of NCI-H1975 cells with an IC50 of 46.82 nM, induces apoptosis, and causes a G2/M phase arrest in these cells. Demonstrating antitumor activity, this compound is applicable in non-small cell lung cancer (NSCLC) research.
价 格：￥电议型 号：T81380产 地：中国大陆
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T81379PROTAC GDI2 Degrader-1；化合物 PROTAC GDI2 Degrader-1PROTAC GDI2 Degrader-1
PROTAC GDI2 Degrader-1 (Compound 21) is a potent degrader of PROTAC GDI2, demonstrating outstanding antitumor activity in vivo within pancreatic xenograft models that overexpress GDI2 [1].
价 格：￥电议型 号：T81379产 地：中国大陆
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T81378PROTAC IRAK4 ligand-3；化合物 PROTAC IRAK4 ligand-3PROTAC IRAK4 ligand-3
PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1].
价 格：￥电议型 号：T81378产 地：中国大陆
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T81377PROTAC NSD3 degrader-1；化合物 PROTAC NSD3 degrader-1PROTAC NSD3 degrader-1
PROTAC NSD3 degrader-1 (compound 56) is a targeted degradation agent for the Nuclear receptor binding SET domain protein NSD3. It effectively induces the degradation of NSD3 in NCI-H1703 and A549 lung cancer cell lines, with DC50 values of 1.43 and 0.94 μM, respectively. Additionally, it hinders H3K36 methylation, triggers apoptosis, and arrests the cell cycle. Furthermore, PROTAC NSD3 degrader-1 diminishes the expression of NSD3-related genes, including CDC25A, ALDH1A1, and IGFBP.
价 格：￥电议型 号：T81377产 地：中国大陆
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T81376PROTAC SMARCA2 degrader-2；化合物 PROTAC SMARCA2 degrader-2PROTAC SMARCA2 degrader-2
PROTAC SMARCA2 degrader-2, a selective and powerful degrader of SMARCA2/4, exhibits an IC50 of <0.1 μΜ in the HeLa HiBiT assay.this compound holds promise for research into cancers related to or deficient in SMARCA4 [1].
价 格：￥电议型 号：T81376产 地：中国大陆
