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  • T79831PROTAC MLKL Degrader-1；化合物 PROTAC MLKL Degrader-1PROTAC MLKL Degrader-1

    PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as part of its structure. It effectively inhibits cell death in a TSZ-induced model of necroptosis.

    价 格：￥电议型 号：T79831产 地：中国大陆

  • T79818PROTAC BRD4 Degrader-21；化合物 PROTAC BRD4 Degrader-21PROTAC BRD4 Degrader-21

    PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its potential for use in anticancer research [1].

    价 格：￥电议型 号：T79818产 地：中国大陆

  • T79742CARM1 degrader-2；化合物 CARM1 degrader-2CARM1 degrader-2

    PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransferase (CARM1). It not only promotes the degradation of CARM1 but also prevents the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, which consequently inhibits breast cancer cell migration [1].

    价 格：￥电议型 号：T79742产 地：中国大陆

  • T79741CARM1 degrader-1；化合物 CARM1 degrader-1CARM1 degrader-1

    PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This compound facilitates the degradation of CARM1 via the VHL-proteasome pathway. By degrading CARM1, PROTAC CARM1 degrader-1 effectively reduces the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, subsequently inhibiting breast cancer cell migration [1].

    价 格：￥电议型 号：T79741产 地：中国大陆

  • T79505PROTAC TG2 degrader-1；化合物 PROTAC TG2 degrader-1PROTAC TG2 degrader-1

    PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM. This compound effectively decreases TG2 levels in ovarian cancer cells through a proteasome-dependent pathway [1].

    价 格：￥电议型 号：T79505产 地：中国大陆

  • T79474GSPT1 degrader-1；化合物 GSPT1 degrader-1GSPT1 degrader-1

    GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].

    价 格：￥电议型 号：T79474产 地：中国大陆

  • T79437NAMPT degrader-3；化合物 NAMPT degrader-3NAMPT degrader-3

    NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism. It exhibits cytotoxic properties and inhibits the proliferation of A2780 cells [1].

    价 格：￥电议型 号：T79437产 地：中国大陆

  • T79383ER degrader 7；化合物 ER degrader 7ER degrader 7

    ER degrader 7 (Compound 35t) is a selective degrader of both ERα and ERβ, and possesses activity as a tubulin polymerization inhibitor. It exhibits potent cell viability inhibition, with IC50 values of 0.06 μM for MCF-7, 2.56 μM for T47D, 15.84 μM for MCF-10A, 1.59 μM for LCC2, 1.67 μM for T47D D538G, and 1.37 μM for T47D Y537S cells. Additionally, ER degrader 7 demonstrates efficacy in suppressing breast cancer tumor growth [1].

    价 格：￥电议型 号：T79383产 地：中国大陆

  • T79382ER degrader 6；化合物 ER degrader 6ER degrader 6

    ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effectively suppresses tumor growth with minimal toxicity [1].

    价 格：￥电议型 号：T79382产 地：中国大陆

  • T79323PROTAC Hsp90α degrader 1；化合物 PROTAC Hsp90α degrader 1PROTAC Hsp90α degrader 1

    Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell lines, MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with respective IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM [1].

    价 格：￥电议型 号：T79323产 地：中国大陆

  • T79315PROTAC TG2 degrader-2；化合物 PROTAC TG2 degrader-2PROTAC TG2 degrader-2

    PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1].

    价 格：￥电议型 号：T79315产 地：中国大陆

  • T79292PROTAC BTK Degrader-5；化合物 PROTAC BTK Degrader-5PROTAC BTK Degrader-5

    PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton´s tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by not affecting CRBN neosubstrates. It also exhibits antiproliferative effects on various lymphoma cell lines, underscoring its potential application in chronic lymphoid malignancies research.

    价 格：￥电议型 号：T79292产 地：中国大陆

  • T79250PROTAC α-synuclein degrader 5；化合物 PROTAC α-synuclein degrader 5PROTAC α-synuclein degrader 5

    PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The compound incorporates the probe molecule sery308 and E3 ligase ligands, making it suitable for neurological disease research [1].

    价 格：￥电议型 号：T79250产 地：中国大陆

  • T79161PROTAC PTPN2 degrader-2 TFA；化合物 PROTAC PTPN2 degrader-2 TFAPROTAC PTPN2 degrader-2 TFA

    PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent degrader of Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2), with potential applications in cancer and metabolic disease research [1].

    价 格：￥电议型 号：T79161产 地：中国大陆

  • T79160PROTAC PTPN2 degrader-2；化合物 PROTAC PTPN2 degrader-2PROTAC PTPN2 degrader-2

    PROTAC PTPN2 degrader-2 (example 187B) is a potent agent capable of degrading PTPN2, which holds potential for research in cancer and metabolic diseases [1].

    价 格：￥电议型 号：T79160产 地：中国大陆

  • T79152PROTAC EGFR degrader 8；化合物 PROTAC EGFR degrader 8PROTAC EGFR degrader 8

    PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells. It effectively inhibits the growth of various cell lines, including H1975, PC-9, and HCC827, with IC50 values of 7.72 nM, 121.9 nM, and 14.21 nM, respectively. This compound is primarily used for cancer research, particularly in the context of non-small cell lung cancer (NSCLC) [1].

    价 格：￥电议型 号：T79152产 地：中国大陆

  • T79148PROTAC KRAS G12C degrader-3；化合物 PROTAC KRAS G12C degrader-3PROTAC KRAS G12C degrader-3

    PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].

    价 格：￥电议型 号：T79148产 地：中国大陆

  • T79147KRAS degrader-1；化合物 KRAS degrader-1KRAS degrader-1

    KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].

    价 格：￥电议型 号：T79147产 地：中国大陆

  • T79144PROTAC MEK1 Degrader-1；化合物 PROTAC MEK1 Degrader-1PROTAC MEK1 Degrader-1

    PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1].

    价 格：￥电议型 号：T79144产 地：中国大陆

  • T79098PROTAC SOS1 degrader-4；化合物 PROTAC SOS1 degrader-4PROTAC SOS1 degrader-4

    PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].

    价 格：￥电议型 号：T79098产 地：中国大陆

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