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  • T78458IR 813 tosylate；化合物 IR 813 tosylateIR 813 tosylate

    IR 813 tosylate is a near-infrared (NIR) fluorescent dye with excitation and emission wavelengths of 815 nm and 840 nm, respectively, utilized for visualizing regional lymph nodes in mice [1].

    价 格：￥电议型 号：T78458产 地：中国大陆

  • T7502PF 05089771 tosylate；化合物PF 05089771 tosylatePF 05089771 tosylate

    PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50: 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50: ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50: 10/20 μM). PF-05089771 is also 1, 000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation o

    价 格：￥电议型 号：T7502产 地：中国大陆

  • T74415Imlunestrant tosylate；化合物 Imlunestrant tosylateImlunestrant tosylate

    Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) exhibiting purely antagonistic properties. It effectively maintains inhibition of estrogen receptor (ER)-dependent gene transcription and inhibits cell growth. This compound is applicable in research on ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC) [1] [2].

    价 格：￥电议型 号：T74415产 地：中国大陆

  • T7386Bretylium tosylate托西溴苄铵溴苄乙胺|||托西溴苄铵

    Bretylium tosylate is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters, a available antiarrhythmic drug for ventricular arrhythmias.

    价 格：￥电议型 号：T7386产 地：中国大陆

  • T73634Milademetan tosylate hydrate；化合物 Milademetan tosylate hydrateMilademetan tosylate hydrate

    Milademetan (DS-3032) tosylate hydrate, an orally active and specific MDM2 inhibitor, is utilized in the study of acute myeloid leukemia (AML) and solid tumors. It induces G1 cell cycle arrest, senescence, and apoptosis, showcasing its therapeutic potential [1] [2].

    价 格：￥电议型 号：T73634产 地：中国大陆

  • T72660VT-1598 tosylate；化合物 VT-1598 tosylateVT-1598 tosylate

    VT-1598 tosylate is a selective, orally active antifungal compound that targets CYP51. It demonstrates efficacy against C. auris.

    价 格：￥电议型 号：T72660产 地：中国大陆

  • T72640GNE-7915 tosylate；化合物 GNE-7915 tosylateGNE-7915 tosylate

    GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.

    价 格：￥电议型 号：T72640产 地：中国大陆

  • T72577Lapatinib tosylate；化合物 Lapatinib tosylateGW2016 tosylate|||GW572016 tosylate|||GW572016 tosylate ;

    Lapatinib tosylate (GW572016), a robust and orally administered inhibitor specifically targeting the tyrosine kinase domains of ErbB-2 and EGFR, exhibits inhibitory concentration 50 (IC50) values of 10.2 nM and 9.8 nM against purified EGFR and ErbB-2, respectively.

    价 格：￥电议型 号：T72577产 地：中国大陆

  • T72465Umbralisib tosylate；化合物 Umbralisib tosylateRP5264 tosylate|||TGR-1202 tosylate ; RP5264 tosylate|||

    Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.

    价 格：￥电议型 号：T72465产 地：中国大陆

  • T71894AZD3229 Tosylate；化合物 AZD3229 TosylateAZD3229 Tosylate

    AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal stromal tumors (GISTs).

    价 格：￥电议型 号：T71894产 地：中国大陆

  • T71781Xylamidine tosylate；化合物 Xylamidine tosylateXylamidine tosylate

    Xylamidine tosylate is a Serotonin inhibitor with reproductive effects

    价 格：￥电议型 号：T71781产 地：中国大陆

  • T71539AFN-1252 tosylate hydrate；化合物 AFN-1252 tosylate hydrateAFN-1252 tosylate hydrate

    AFN-1252, also known as AFN-12520000; API-1252; Debio-1452, is FASII Inhibitor which is potentially for the treatment of acute bacterial skin. AFN-1252 exhibits typical MIC(90) values of ≤0·015 μg/ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. AFN-1252 efficiently blocked daptomycin-induced phospholipid decoy production, even in the case of isolates resistant to AFN-1252, which prevented the inactivation of daptomyci

    价 格：￥电议型 号：T71539产 地：中国大陆

  • T71397Setileuton tosylate；化合物 Setileuton tosylateSetileuton tosylate

    Setileuton, also known as MK0633, is a potent and selective 5-lipoxygenase inhibitor which is under investigation for the treatment of asthma and atherosclerosis.

    价 格：￥电议型 号：T71397产 地：中国大陆

  • T71354AMG-222 tosylate；化合物 AMG-222 tosylateAMG-222 tosylate

    AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.

    价 格：￥电议型 号：T71354产 地：中国大陆

  • T70929Naldemedine tosylate；化合物 Naldemedine tosylateS-297995 tosylate；S-297995 tosylate

    Naldemedine tosylate (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards human recombinant μ-, δ-, and κ-opioid receptors, respectively. It is utilized in research on opioid-induced constipation (OIC). Additionally, Naldemedine tosylate is anticipated to interact with the 3CL proenzyme encoded by the SARS-CoV-2 genome.

    价 格：￥电议型 号：T70929产 地：中国大陆

  • T70876KW-2450 Tosylate；化合物 KW-2450 TosylateKW-2450 Tosylate

    KW-2450 Tosylate is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 Tosylate selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in t

    价 格：￥电议型 号：T70876产 地：中国大陆

  • T70787AZD1446 tosylate；化合物 AZD1446 tosylateAZD1446 tosylate

    AZD1446 tosylate, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 tosylate showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer´s disease.

    价 格：￥电议型 号：T70787产 地：中国大陆

  • T70207Pimodivir tosylate；化合物 Pimodivir tosylatePimodivir tosylate

    Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay

    价 格：￥电议型 号：T70207产 地：中国大陆

  • T70104Verubecestat tosylate；化合物 Verubecestat tosylateVerubecestat tosylate

    Verubecestat tosylate, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat tosylate is a promising novel therapeutic drug candidate in Alzheimer´s disease. Verubecestat tosylate reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.

    价 格：￥电议型 号：T70104产 地：中国大陆

  • T70008Bomedemstat ditosylate；化合物 Bomedemstat ditosylateBomedemstat ditosylate

    Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antago

    价 格：￥电议型 号：T70008产 地：中国大陆

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