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T75095STING agonist-27;化合物 STING agonist-27STING agonist-27
STING agonist-27 (CF509) is a non-nucleotide, small-molecule agonist of STING, which activates STING and demonstrates activity against SARS-CoV series strains [1].
价 格:¥电议型 号:T75095产 地:中国大陆
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T75093STING agonist-25;化合物 STING agonist-25STING agonist-25
STING agonist-23 (CF505) is a non-nucleotide, small-molecule compound that stimulates STING, enhancing the phosphorylation of STING, TBK1, and IRF3. It elevates the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells and demonstrates efficacy against SARS-CoV strains [1].
价 格:¥电议型 号:T75093产 地:中国大陆
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T75092STING agonist-24;化合物 STING agonist-24STING agonist-24
STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells, demonstrating activity against SARS-CoV series strains [1].
价 格:¥电议型 号:T75092产 地:中国大陆
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T75011STING-IN-5;化合物 STING-IN-5STING-IN-5
STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in macrophages, exhibiting an IC50 of 1.15 μM. This compound dampens the inflammatory response and offers potential for research into anti-inflammatory diseases and sepsis [1].
价 格:¥电议型 号:T75011产 地:中国大陆
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T74976Antifungal agent 46;化合物 Antifungal agent 46Antifungal agent 46
Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].
价 格:¥电议型 号:T74976产 地:中国大陆
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T74959Antifungal agent 41;化合物 Antifungal agent 41Antifungal agent 41
Antifungal Agent 41 (compound B01), an effective inhibitor of Candida albicans both in vitro and in vivo, is a potential research tool for invasive fungal infections [1].
价 格:¥电议型 号:T74959产 地:中国大陆
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T74949Antifungal agent 37;化合物 Antifungal agent 37Antifungal agent 37
Antifungal agent 37 is a heterocyclic disulfide that exhibits antifungal activity [1].
价 格:¥电议型 号:T74949产 地:中国大陆
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T74896PROTAC STING Degrader-1;化合物 PROTAC STING Degrader-1PROTAC STING Degrader-1
PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader exhibiting a DC50 of 3.2 μM and demonstrates anti-inflammatory activity [1].
价 格:¥电议型 号:T74896产 地:中国大陆
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T74886RNA splicing modulator 3;化合物 RNA splicing modulator 3RNA splicing modulator 3
RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].
价 格:¥电议型 号:T74886产 地:中国大陆
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T74885RNA splicing modulator 2;化合物 RNA splicing modulator 2RNA splicing modulator 2
RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .
价 格:¥电议型 号:T74885产 地:中国大陆
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T74884RNA splicing modulator 1;化合物 RNA splicing modulator 1RNA splicing modulator 1
RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].
价 格:¥电议型 号:T74884产 地:中国大陆
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T74877GalNAc unconjugated/naked Fitusiran;化合物 GalNAc unconjugated/naked FitusiranGalNAc unconjugated/naked
GalNAc unconjugated/naked Fitusiran, an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. GalNAc unconjugated/naked Fitusiran increases thrombin generation and has the potential for the research of the hemophilia [1] .
价 格:¥电议型 号:T74877产 地:中国大陆
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T74876GalNAc unconjugated/naked Inclisiran;化合物 GalNAc unconjugated/naked InclisiranGalNAc unconjugated/nak
Inclisiran (unconjugated/naked) is a double-stranded small interfering RNA (siRNA) that lacks GalNAc conjugation. This compound selectively inhibits the transcription of PCSK-9, making it applicable in the research of hyperlipidemia and cardiovascular disease (CVD) [1].
价 格:¥电议型 号:T74876产 地:中国大陆
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T74831Antifungal agent 51;化合物 Antifungal agent 51Antifungal agent 51
Antifungal agent 51 (5c) exhibits potent antifungal activity against Candida albicans FDC 151, Candida parapsilosis ATCC 22019, and Candida tropicalis FDC 138, with a minimum inhibitory concentration (MIC) value of less than 0.063 μg/mL. It demonstrates low toxicity to cells and no carcinogenicity [1].
价 格:¥电议型 号:T74831产 地:中国大陆
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T74809STING agonist-30;STING 激动剂30STING agonist-30
STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a variety of viruses including HSV (Herpes Simplex Virus), rotavirus, and SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).
价 格:¥电议型 号:T74809产 地:中国大陆
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T74772Antifungal agent 47;化合物 Antifungal agent 47Antifungal agent 47
Antifungal agent 47 (compound 3b) exhibits the most potent and broad-spectrum fungicidal properties, including significant inhibition of respiration and adenosine 5′-triphosphate synthesis, showcasing its potential as an effective fungicide [1].
价 格:¥电议型 号:T74772产 地:中国大陆
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T74735Gly-Cyclopropane-Exatecan;化合物 Gly-Cyclopropane-ExatecanGly-Cyclopropane-Exatecan
Gly-Cyclopropane-Exatecan, a DNA Topoisomerase I inhibitor containing Exatecan, is key in synthesizing the anti-B7-H4 ADC, specifically the ADC hu2F7-Exatecan (compound 34). This compound demonstrated antitumor activity both in vivo and in vitro [1].
价 格:¥电议型 号:T74735产 地:中国大陆
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T74718STING modulator-5;化合物 STING modulator-5STING modulator-5
STING modulator-5 (compound 38), a STING modulator, exhibits a pIC50 value of 9.5 and antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. Additionally, it acts as an antagonist of THP-1 cells, making it applicable in immunological disease research [1].
价 格:¥电议型 号:T74718产 地:中国大陆
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T74687N-Stearoylsphingomyelin;化合物 N-StearoylsphingomyelinN-Stearoylsphingomyelin
N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin), a sphingolipid, inhibits Phospholipase Cδ1 (PLCδ1) [1].
价 格:¥电议型 号:T74687产 地:中国大陆
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T74677STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA;化合物 STING agonist-20-Ala-amide-PEG2-C2-NH2 TFASTING agoni
STING Agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA, an active compound that interacts with the stimulator of interferon genes (STING), is utilized in the synthesis of immune-stimulating antibody conjugates (ISAC). This compound is also employed in cancer research [1].
价 格:¥电议型 号:T74677产 地:中国大陆