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T1615Irbesartan厄贝沙坦;SR-47436;BMS-186295
Irbesartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.
价 格:¥电议型 号:T1615产 地:中国大陆
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T16144MRX-2843UNC2371
MRX-2843 is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).
价 格:¥电议型 号:T16144产 地:中国大陆
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T16143MRTX-1257
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above the
价 格:¥电议型 号:T16143产 地:中国大陆
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T16140MRS 1754
MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.
价 格:¥电议型 号:T16140产 地:中国大陆
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T16136MRS-1706
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
价 格:¥电议型 号:T16136产 地:中国大陆
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T16133MRK-560
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
价 格:¥电议型 号:T16133产 地:中国大陆
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T16130Mps1-IN-3
Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
价 格:¥电议型 号:T16130产 地:中国大陆
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T1613Hydralazine hydrochloride盐酸肼屈嗪;Hydralazine HCl;Apresoline
Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium inf
价 格:¥电议型 号:T1613产 地:中国大陆
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T16129MPI_5a
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).
价 格:¥电议型 号:T16129产 地:中国大陆
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T16128MP-A08
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).
价 格:¥电议型 号:T16128产 地:中国大陆
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T16125MMV390048
MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart fro
价 格:¥电议型 号:T16125产 地:中国大陆
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T16124MMP13-IN-3
MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.
价 格:¥电议型 号:T16124产 地:中国大陆
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T1612Neostigmine methyl sulfateNormastigmin;Syntostigmin;Hodostin;甲基硫酸新斯的明;甲硫酸新斯的明
Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
价 格:¥电议型 号:T1612产 地:中国大陆
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T16118MLS0315771
MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).
价 格:¥电议型 号:T16118产 地:中国大陆
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T16116MLN-4760
MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
价 格:¥电议型 号:T16116产 地:中国大陆
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T16115MLi-2
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphory
价 格:¥电议型 号:T16115产 地:中国大陆
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T16110ML418
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
价 格:¥电议型 号:T16110产 地:中国大陆
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T1611Isotretinoin异维A酸;13-cis-Retinoic acid
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic ac
价 格:¥电议型 号:T1611产 地:中国大陆
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T16104ML-9
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 c
价 格:¥电议型 号:T16104产 地:中国大陆
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T16102ML-792
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in
价 格:¥电议型 号:T16102产 地:中国大陆