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  • T79698S217879；化合物 S217879S217879

    S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway. This compound is applicable in research on non-alcoholic steatohepatitis (NASH) [1].

    价 格：￥电议型 号：T79698产 地：中国大陆

  • T78879CXCR4-IN-2；化合物 CXCR4-IN-2CXCR4-IN-2

    CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colorectal cancer (CRC) cells. It induces G2/M phase cell cycle arrest and apoptosis [1].

    价 格：￥电议型 号：T78879产 地：中国大陆

  • T78799BChE/HDAC6-IN-1；化合物 BChE/HDAC6-IN-1BChE/HDAC6-IN-1

    BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42-induced mouse model, indicating its potential utility in Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78799产 地：中国大陆

  • T78798MY-673；化合物 MY-673MY-673

    MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein expression in the TGF-β/SMAD pathway. This compound effectively reduces cell proliferation and migration while inducing apoptosis in both in vivo and in vitro settings [1].

    价 格：￥电议型 号：T78798产 地：中国大陆

  • T78797FHND5071；化合物 FHND5071FHND5071

    FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor disease research [1].

    价 格：￥电议型 号：T78797产 地：中国大陆

  • T78796MHJ-627；化合物 MHJ-627MHJ-627

    MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading to the promotion of cancer cell death [1].

    价 格：￥电议型 号：T78796产 地：中国大陆

  • T78795IDO1/TDO-IN-6；化合物 IDO1/TDO-IN-6IDO1/TDO-IN-6

    IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO. The compound further demonstrates Ki values of 1.9 μM for IDO1 and 3.1 μM for TDO, marking its potential utility in cancer and immunology research [1].

    价 格：￥电议型 号：T78795产 地：中国大陆

  • T78794α-Glucosidase-IN-31；化合物 α-Glucosidase-IN-31α-Glucosidase-IN-31

    α-Glucosidase-IN-31 (compound R1) is a potent oral α-Glucosidase inhibitor with an IC50 of 10.1 μM, demonstrating significant blood glucose reduction and antidiabetic activity [1].

    价 格：￥电议型 号：T78794产 地：中国大陆

  • T78793MAOA-IN-1；化合物 MAOA-IN-1MAOA-IN-1

    MAOA-IN-1 (compound 15) is an orally-active inhibitor of monoamine oxidase A (MAOA) that exhibits cytotoxic effects on prostate cancer cells. This compound demonstrates Caco-2 permeability while maintaining reduced central nervous system (CNS) permeability, indicating its potential utility in anti-cancer and anti-inflammatory research [1].

    价 格：￥电议型 号：T78793产 地：中国大陆

  • T78792Multi-kinase-IN-4；化合物 Multi-kinase-IN-4Multi-kinase-IN-4

    Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.18, and 2.09 μM. It exhibits broad-spectrum anti-cancer properties in HepG2, MCF-7, MDA-231, and HeLa cell lines, with IC50 values ranging from 1.94 to 7.1 ?M, and demonstrates lower toxicity in WI-38 cells (IC50 = 40.85 ?M). Additionally, it induces apoptosis and causes S-phase cell cycle arrest in HepG2 cells, and holds potential for can

    价 格：￥电议型 号：T78792产 地：中国大陆

  • T78791AMPK activator 12；AMPK 激活剂12AMPK activator 12

    AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.

    价 格：￥电议型 号：T78791产 地：中国大陆

  • T78790J-1048；化合物 J-1048J-1048

    J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Smad signaling pathway [1].

    价 格：￥电议型 号：T78790产 地：中国大陆

  • T7879TASP0415914；化合物TASP0415914TASP0415914

    TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T

    价 格：￥电议型 号：T7879产 地：中国大陆

  • T77879MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan；化合物 MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-ami

    MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan is an antibody-drug conjugate (ADC)[1].

    价 格：￥电议型 号：T77879产 地：中国大陆

  • T77613SNX7；化合物SNX7WAY-323879；WAY-323879

    SNX7 (WAY-323879) is an inhibitor of the cell cycle protein-dependent kinase inhibitor (CDKI) pathway. SNX7 can be utilized as a tool for investigating the aging process and other diseases associated with CDKI.

    价 格：￥电议型 号：T77613产 地：中国大陆

  • T76879Vesencumab；化合物 VesencumabVesencumab

    Vesencumab (MNRP-1685A), an IG1 antibody targeting neuropilin-1 (NRP-1), inhibits the interaction between NRP-1 and VEGFR-2. This action confers anti-angiogenic and anti-neoplastic properties to Vesencumab. It is utilized in studying metastatic solid tumors, notably ovarian cancer [1] [2].

    价 格：￥电议型 号：T76879产 地：中国大陆

  • T75879Men 10376 TFA；化合物 Men 10376 TFAMen 10376 TFA

    Men 10376 TFA is a selective antagonist of the tachykinin NK-2 receptor, displaying a K i value of 4.4 μM specifically for the NK-2 receptor in rat small intestine [1].

    价 格：￥电议型 号：T75879产 地：中国大陆

  • T74879306-N16B；化合物 306-N16B306-N16B

    306-N16B is a lipid nanoparticle designed for the systemic co-delivery of Cas9 mRNA and sgRNA, facilitating the transport of mRNA to pulmonary endothelial cells. This compound is advantageous for research focused on genome editing-based therapies [1].

    价 格：￥电议型 号：T74879产 地：中国大陆

  • T7484LWKYMVM 2TFA(187986-17-0(free base))；化合物WKYMVM 2TFAWKYMVM 2TFA(187986-17-0(free base))

    WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.

    价 格：￥电议型 号：T7484L产 地：中国大陆

  • T72879Misetionamide；化合物 MisetionamideMisetionamide

    Misetionamide, an orally active oxathiazin-like compound, functions as a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with antineoplastic activity, making it applicable in cancer research.

    价 格：￥电议型 号：T72879产 地：中国大陆

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