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T81375PROTAC TTK degrader-1；化合物 PROTAC TTK degrader-1PROTAC TTK degrader-1
PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].
价 格：￥电议型 号：T81375产 地：中国大陆
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T81374PROTAC TTK degrader-2；化合物 PROTAC TTK degrader-2PROTAC TTK degrader-2
PROTAC TTK Degrader-2 is a potent threonine tyrosine kinase (TTK) PROTAC degrader, achieving DC50 values of 3.1 nM in COLO-205 cells and 12.4 nM in HCT-116 cells. It demonstrates effective target degradation and anticancer activity in a COLO-205 human colorectal cancer cell xenograft mouse model [1].
价 格：￥电议型 号：T81374产 地：中国大陆
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T79904PROTAC CDK9/CycT1 Degrader-2；化合物 PROTAC CDK9/CycT1 Degrader-2PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].
价 格：￥电议型 号：T79904产 地：中国大陆
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T79831PROTAC MLKL Degrader-1；化合物 PROTAC MLKL Degrader-1PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as part of its structure. It effectively inhibits cell death in a TSZ-induced model of necroptosis.
价 格：￥电议型 号：T79831产 地：中国大陆
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T79818PROTAC BRD4 Degrader-21；化合物 PROTAC BRD4 Degrader-21PROTAC BRD4 Degrader-21
PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its potential for use in anticancer research [1].
价 格：￥电议型 号：T79818产 地：中国大陆
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T79505PROTAC TG2 degrader-1；化合物 PROTAC TG2 degrader-1PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM. This compound effectively decreases TG2 levels in ovarian cancer cells through a proteasome-dependent pathway [1].
价 格：￥电议型 号：T79505产 地：中国大陆
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T79323PROTAC Hsp90α degrader 1；化合物 PROTAC Hsp90α degrader 1PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell lines, MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with respective IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM [1].
价 格：￥电议型 号：T79323产 地：中国大陆
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T79315PROTAC TG2 degrader-2；化合物 PROTAC TG2 degrader-2PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1].
价 格：￥电议型 号：T79315产 地：中国大陆
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T79292PROTAC BTK Degrader-5；化合物 PROTAC BTK Degrader-5PROTAC BTK Degrader-5
PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton´s tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by not affecting CRBN neosubstrates. It also exhibits antiproliferative effects on various lymphoma cell lines, underscoring its potential application in chronic lymphoid malignancies research.
价 格：￥电议型 号：T79292产 地：中国大陆
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T79250PROTAC α-synuclein degrader 5；化合物 PROTAC α-synuclein degrader 5PROTAC α-synuclein degrader 5
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The compound incorporates the probe molecule sery308 and E3 ligase ligands, making it suitable for neurological disease research [1].
价 格：￥电议型 号：T79250产 地：中国大陆
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T79161PROTAC PTPN2 degrader-2 TFA；化合物 PROTAC PTPN2 degrader-2 TFAPROTAC PTPN2 degrader-2 TFA
PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent degrader of Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2), with potential applications in cancer and metabolic disease research [1].
价 格：￥电议型 号：T79161产 地：中国大陆
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T79160PROTAC PTPN2 degrader-2；化合物 PROTAC PTPN2 degrader-2PROTAC PTPN2 degrader-2
PROTAC PTPN2 degrader-2 (example 187B) is a potent agent capable of degrading PTPN2, which holds potential for research in cancer and metabolic diseases [1].
价 格：￥电议型 号：T79160产 地：中国大陆
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T79152PROTAC EGFR degrader 8；化合物 PROTAC EGFR degrader 8PROTAC EGFR degrader 8
PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells. It effectively inhibits the growth of various cell lines, including H1975, PC-9, and HCC827, with IC50 values of 7.72 nM, 121.9 nM, and 14.21 nM, respectively. This compound is primarily used for cancer research, particularly in the context of non-small cell lung cancer (NSCLC) [1].
价 格：￥电议型 号：T79152产 地：中国大陆
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T79148PROTAC KRAS G12C degrader-3；化合物 PROTAC KRAS G12C degrader-3PROTAC KRAS G12C degrader-3
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].
价 格：￥电议型 号：T79148产 地：中国大陆
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T79144PROTAC MEK1 Degrader-1；化合物 PROTAC MEK1 Degrader-1PROTAC MEK1 Degrader-1
PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1].
价 格：￥电议型 号：T79144产 地：中国大陆
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T79098PROTAC SOS1 degrader-4；化合物 PROTAC SOS1 degrader-4PROTAC SOS1 degrader-4
PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].
价 格：￥电议型 号：T79098产 地：中国大陆
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T79097PROTAC IRAK4 degrader-8；化合物 PROTAC IRAK4 degrader-8PROTAC IRAK4 degrader-8
PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].
价 格：￥电议型 号：T79097产 地：中国大陆
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T79067PROTAC BTK Degrader-3；化合物 PROTAC BTK Degrader-3PROTAC BTK Degrader-3
PROTAC BTK Degrader-3 is a potent degrader of Bruton´s tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells. This compound shows promise for research into B-cell malignancies, such as chronic lymphoid malignancies [1].
价 格：￥电议型 号：T79067产 地：中国大陆
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T78956PROTAC BRD3/BRD4-L degrader-2；化合物 PROTAC BRD3/BRD4-L degrader-2PROTAC BRD3/BRD4-L degrader-2
PROTAC BRD3/BRD4-L degrader-2, a PROTAC molecule, selectively degrades cellular BRD3 and BRD4-L with K i values of 16.91 and 2.8 nM, respectively, and exhibits robust antitumor activity in mouse xenograft models, serving as a research tool for cancer [1].
价 格：￥电议型 号：T78956产 地：中国大陆
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T78928PROTAC CDK9 degrader-8；化合物 PROTAC CDK9 degrader-8PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].
价 格：￥电议型 号：T78928产 地：中国大陆
