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T69221BMS-554417；化合物 BMS-554417BMS-554417
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosph
价 格：￥电议型 号：T69221产 地：中国大陆
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T69181BMS-566394；化合物 BMS-566394BMS-566394
BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE).
价 格：￥电议型 号：T69181产 地：中国大陆
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T6789BMS582949；化合物BMS582949BMS 582949|||PS540446|||BMS-582949；BMS 582949|||PS540446|||BMS-582949
BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM, inhibiting both p38 kinase activity and activation of p38.
价 格：￥电议型 号：T6789产 地：中国大陆
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T6724Voreloxin；化合物VoreloxinVosaroxin|||AG 7352|||SNS-595；Vosaroxin|||AG 7352|||SNS-595
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
价 格：￥电议型 号：T6724产 地：中国大陆
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T65086Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride；化合物T65086Cis-5-Norbornene-exo-2,3-dicarboxylic Anhyd
Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM) and SK-Hep1 (IC50= 151 μM) cells and inhibits protein phosphatase 2A.
价 格：￥电议型 号：T65086产 地：中国大陆
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T6419BMS-536924；胰岛素样生长因子-1 受体拮抗剂HY-10262|||BMS 536924|||CS-0117；HY-10262|||胰岛素样生长因子-1 受体拮抗剂|||BMS 536924|
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
价 格：￥电议型 号：T6419产 地：中国大陆
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T63246BMS-566419；化合物 BMS-566419BMS-566419
BMS-566419 is an acridinone-based inhibitor of inosine 5´-monophosphate dehydrogenase (IMPDH), a key enzyme for the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility in the study of graft rejection.
价 格：￥电议型 号：T63246产 地：中国大陆
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T6103VS-5584；化合物VS5584SB2343|||VS 5584|||VS5584；SB2343|||VS 5584|||VS5584
VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.
价 格：￥电议型 号：T6103产 地：中国大陆
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T6036Brivanib；布立尼布BMS-540215；BMS-540215|||布立尼布
Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
价 格：￥电议型 号：T6036产 地：中国大陆
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T5390BMS-599626 Hydrochloride；BMS-599626盐酸盐AC480 Hydrochloride；AC480 Hydrochloride
BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 Hydrochloride inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.
价 格：￥电议型 号：T5390产 地：中国大陆
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T4598BMS-5；化合物BMS5BMS5|||LIMKi 3；BMS5|||LIMKi 3
BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
价 格：￥电议型 号：T4598产 地：中国大陆
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T4460Dapagliflozin ((2S)-1,2-propanediol, hydrate)；达格列净 (2S)-1,2-丙二醇水合物BMS-512148 (2S)-1,2-propanediol, h
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the treatment of type 2 diabetes mellitus (T2DM). It inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney.
价 格：￥电议型 号：T4460产 地：中国大陆
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T4199Desmethyl-VS-5584；化合物Desmethyl-VS-5584Desmethyl-VS-5584
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
价 格：￥电议型 号：T4199产 地：中国大陆
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T4134LOTS514；化合物OTS514OTS514 HCl|||OTS514 Hydrochloride|||OTS-514|||OTS 514；OTS514 HCl|||OTS514 Hydrochlor
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
价 格：￥电议型 号：T4134L产 地：中国大陆
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T4134OTS514 hydrochloride；化合物OTS514 hydrochlorideOTS-514 hydrochloride|||OTS514 hydrochloride(1338540-63-
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
价 格：￥电议型 号：T4134产 地：中国大陆
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T39927Zeteletinib hemiadipateZeteletinib hemiadipateBOS-172738 hemiadipate|||DS-5010hemiadipate|||Zeteleti
Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects.
价 格：￥电议型 号：T39927产 地：中国大陆
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T38994NHS-5(6)Carboxyrhodamine；NHS-5(6)CarboxyrhodamineNHS-5(6)Carboxyrhodamine
NHS-5(6)Carboxyrhodamine is a fluorescent dye employed for precise labeling of proteins through fluorescence. This compound enables the achievement of accurate ratios of dye to protein, even when used under native conditions.
价 格：￥电议型 号：T38994产 地：中国大陆
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T36382all-trans-5,6-epoxy Retinoic Acid；all-trans-5,6-epoxy Retinoic Acidall-trans-5,6-epoxy Retinoic Acid
all-trans-5,6-epoxy Retinoic Acid can be used in related research in the field of life sciences. Its product number is T36382 and CAS number is 13100-69-1.
价 格：￥电议型 号：T36382产 地：中国大陆
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T3462BMS-582949 hydrochloride；化合物BMS-582949 HClBMS-582949 HCl；BMS-582949 HCl
The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).
价 格：￥电议型 号：T3462产 地：中国大陆
