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  • T73548D6808；化合物 D6808D6808

    D6808, a selective and potent c?Met inhibitor, exhibits an IC50 of 2.9 nM, effectively inducing cell apoptosis and cell cycle arrest. This compound is utilized in researching non-small cell lung cancer (NSCLC) and gastric cancers.

    价 格：￥电议型 号：T73548产 地：中国大陆

  • T7136AZD-6280；化合物AZD6280AZD-6280

    AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder.

    价 格：￥电议型 号：T7136产 地：中国大陆

  • T71329Theophylline-d6；化合物 Theophylline-d6Theophylline-d6

    Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F

    价 格：￥电议型 号：T71329产 地：中国大陆

  • T71328Theobromine-d6；化合物 Theobromine-d6Theobromine-d6

    Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.

    价 格：￥电议型 号：T71328产 地：中国大陆

  • T71327Paraxanthine-d6；化合物 Paraxanthine-d6Paraxanthine-d6

    Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni

    价 格：￥电议型 号：T71327产 地：中国大陆

  • T71306Gemfibrozil-d6；化合物 Gemfibrozil-d6Gemfibrozil-d6

    Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l

    价 格：￥电议型 号：T71306产 地：中国大陆

  • T71300Pentoxifylline-d6；化合物 Pentoxifylline-d6Pentoxifylline-d6

    Pentoxifylline-d6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 ?M. Pentoxifylline (1, 2, and 3 mM) inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5, 10, and 20 mg/

    价 格：￥电议型 号：T71300产 地：中国大陆

  • T71285Metaxalone-d6；化合物 Metaxalone-d6Metaxalone-d6

    Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 ?M. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone

    价 格：￥电议型 号：T71285产 地：中国大陆

  • T71211Rizatriptan-d6 benzoate salt；化合物 Rizatriptan-d6 benzoate saltRizatriptan-d6 benzoate salt

    Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors. Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries. In vivo, rizatriptan reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mouse

    价 格：￥电议型 号：T71211产 地：中国大陆

  • T71206Tiagabine-d6 hydrochloride；化合物 Tiagabine-d6 hydrochlorideTiagabine-d6 hydrochloride

    Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 ?mol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of

    价 格：￥电议型 号：T71206产 地：中国大陆

  • T71129AZD6564；化合物 AZD6564AZD6564

    AZD6564 is a fibrinolysis inhibitor which acts via interference of a protein-?protein interaction.

    价 格：￥电议型 号：T71129产 地：中国大陆

  • T70990ADMA-d6；化合物 ADMA-d6ADMA-d6

    NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da

    价 格：￥电议型 号：T70990产 地：中国大陆

  • T70808Cabazitaxel-d6；化合物 Cabazitaxel-d6Cabazitaxel-d6

    Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance

    价 格：￥电议型 号：T70808产 地：中国大陆

  • T70316AZD6642；化合物 AZD6642AZD6642

    AZD6642 is a potential and selective 5-Lipoxygenase activating Protein (FLAP) inhibitor. AZD6642 shows high specific potency and low lipophilicity resulting in a selective and metabolically stable profile. Based on initial PK/PD relations a low dose to human was predicted.

    价 格：￥电议型 号：T70316产 地：中国大陆

  • T70186Methazolamide-d6；化合物 Methazolamide-d6Methazolamide-d6

    Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re

    价 格：￥电议型 号：T70186产 地：中国大陆

  • T69600Spermidine-d6；化合物 Spermidine-d6Spermidine-d6

    Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 ?M) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 ?M and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki

    价 格：￥电议型 号：T69600产 地：中国大陆

  • T69356Cindunistat；化合物CindunistatCindunistat free base|||SD6010|||SD-6010；Cindunistat free base|||SD6010|||

    Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.

    价 格：￥电议型 号：T69356产 地：中国大陆

  • T670136-Methylnicotinic acid；化合物 6-Methylnicotinic acid6-Methylnicotinic acid

    6-Methylnicotinic acid is a useful organic compound for research related to life sciences. The catalog number is T67013 and the CAS number is 3222-47-7.

    价 格：￥电议型 号：T67013产 地：中国大陆

  • T6635EMD638683；化合物EMD638683EMD638683

    EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).

    价 格：￥电议型 号：T6635产 地：中国大陆

  • T652856-Amino-2-naphthoic acid；化合物 6-Amino-2-naphthoic acid6-Amino-2-naphthoic acid

    6-Amino-2-naphthoic acid is a useful organic compound for research related to life sciences. The catalog number is T65285 and the CAS number is 116668-47-4.

    价 格：￥电议型 号：T65285产 地：中国大陆

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