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  • T60691AChE/BChE/BACE-1-IN-2；化合物 AChE/BChE/BACE-1-IN-2AChE/BChE/BACE-1-IN-2

    AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 values of 0.069, 0.097 and 0.127 μM against hAChE, hBACE-1 and hBChE, respectively. AChE/BChE/BACE-1-IN-2 shows potential disassembly of Aβ aggregates and neuroprotective activity against Aβ-induced stress with excellent brain permeation [1].

    价 格：￥电议型 号：T60691产 地：中国大陆

  • T60682Elongation factor P-IN-2；化合物 Elongation factor P-IN-2Elongation factor P-IN-2

    Elongation factor P-IN-2 is a β-lysine derivative compound which is a potent elongation factor P (EFP) inhibitor. Elongation factor P-IN-2 affects the E. coli proliferation rates [1].

    价 格：￥电议型 号：T60682产 地：中国大陆

  • T60678hMAO-B-IN-2；化合物 hMAO-B-IN-2hMAO-B-IN-2

    hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible inhibitor of hMAO-B (IC 50 = 4 nM) that can be used for the research of alzheimer’s disease. hMAO-B-IN-2 exhibits good neuroprotective effects and low toxicity in SH-SY5Y cell [1].

    价 格：￥电议型 号：T60678产 地：中国大陆

  • T60658hMAO-B/MB-COMT-IN-2；化合物 hMAO-B/MB-COMT-IN-2hMAO-B/MB-COMT-IN-2

    hMAO-B/MB-COMT-IN-2 is a dual inhibitor of MAO-B/MB-COMT with IC 50s of 4.27 μΜ and 2.69 μΜ for hMAO-B and MB-COMT, respectively. hMAO-B/MB-COMT-IN-2 protects cells from oxidative damage that can be used in the neurodegeneration disease research, for example, Parkinson’s Disease (PD) [1].

    价 格：￥电议型 号：T60658产 地：中国大陆

  • T60652NHE3-IN-2；化合物 NHE3-IN-2NHE3-IN-2

    NHE3-IN-2 is an inhibitor of Na + /H + exchanger-3 (NHE3)[1].

    价 格：￥电议型 号：T60652产 地：中国大陆

  • T60645Glutamate-5-kinase-IN-2；化合物 Glutamate-5-kinase-IN-2Glutamate-5-kinase-IN-2

    Glutamate-5-kinase-IN-2 (compound 54) exhibits G5K inhibition by promotes conformational changes at the L-glutamate binding site that is a potent glutamate-5-kinase (G5K) inhibitor with an MIC of 4.2 μM. Glutamate-5-kinase-IN-2 has the potential for anti-TB research [1].

    价 格：￥电议型 号：T60645产 地：中国大陆

  • T60641Vanin-1-IN-2；化合物 Vanin-1-IN-2Vanin-1-IN-2

    Vanin-1-IN-2 is a potent inhibitor of vanin-1(IC 50 = 162 nM) which is a cell-surface-associated, glycosylphosphatidyl inositol (GPI)-anchored protein expressed at high levels in the kidney, liver, and small intestine [1].

    价 格：￥电议型 号：T60641产 地：中国大陆

  • T60627ELOVL1-IN-2；化合物ELOVL1-IN-2ELOVL1-IN-2

    ELOVL1-IN-2, a compound known as an inhibitor of the elongation of very long chain fatty acid 1 (ELOVL1) enzyme, exhibits a weak inhibitory effect on ELOVL1 (with an IC50 of 21 μM) and demonstrates moderate potency in a primary cellular assay conducted on HEK293 C26 cells (with an IC50 of 6.7 μM) [1].

    价 格：￥电议型 号：T60627产 地：中国大陆

  • T60585RSK2-IN-2；化合物 RSK2-IN-2RSK2-IN-2

    RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].

    价 格：￥电议型 号：T60585产 地：中国大陆

  • T60567PARP10/15-IN-2；化合物 PARP10/15-IN-2PARP10/15-IN-2

    PARP10/15-IN-2 (Compound 8h) is a dual inhibitor of PARP10 and PARP15 with IC 50 values of 0.15 μM and 0.37 μM, respectively. PARP10/15-IN-2 can enter cells and rescue cells from apoptosis [1].

    价 格：￥电议型 号：T60567产 地：中国大陆

  • T60564PI3K/Akt/mTOR-IN-2；PI3K/Akt/mTOR抑制剂2PI3K/Akt/mTOR-IN-2

    PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces cycle arrest and apoptosis in cancer cells. PI3K/Akt/mTOR-IN-2 has anticancer activity and can induce cycle arrest and apoptosis in cancer cells.

    价 格：￥电议型 号：T60564产 地：中国大陆

  • T60513NMDA-IN-2；化合物 NMDA-IN-2NMDA-IN-2

    NMDA-IN-2 (compound 6b) is a Procaine derivative that is an inhibitor of NMDA receptor 2B subtype [1].

    价 格：￥电议型 号：T60513产 地：中国大陆

  • T60499IDO1/TDO-IN-2；化合物 IDO1/TDO-IN-2IDO1/TDO-IN-2

    IDO1/TDO-IN-2 (Compound 1) is a potent IDO1/TDO dual inhibitor with IC50s of 0.1 and 0.07 μM, respectively. IDO1/TDO-IN-2 has the potential for cancer research[1].

    价 格：￥电议型 号：T60499产 地：中国大陆

  • T60470KPC-2-IN-2；化合物 KPC-2-IN-2KPC-2-IN-2

    KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor with Ki of 0.038 μM. KPC-2-IN-2 can enhance the activity of cefotaxime in E. coli expressing KPC-2 [1].

    价 格：￥电议型 号：T60470产 地：中国大陆

  • T60464COX-2-IN-20；化合物 COX-2-IN-20COX-2-IN-20

    COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].

    价 格：￥电议型 号：T60464产 地：中国大陆

  • T60452PCAF-IN-2；化合物 PCAF-IN-2PCAF-IN-2

    PCAF-IN-2 (compound 17) is a potent inhibitor of PCAF with an IC50 of 5.31 ?M. PCAF-IN-2 exhibits anti-tumor activity. CAF-IN-2 induces cell apoptosis and arrest the cell cycle at the G2/M phase[1].

    价 格：￥电议型 号：T60452产 地：中国大陆

  • T60404NLRP3/AIM2-IN-2；化合物NLRP3/AIM2-IN-2NLRP3/AIM2-IN-2

    NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.

    价 格：￥电议型 号：T60404产 地：中国大陆

  • T60394Haspin-IN-2；化合物 Haspin-IN-2Haspin-IN-2

    Haspin-IN-2 (compound 4) is a potent, selective inhibitor of haspin, exhibiting an IC50 of 50 nM. Additionally, it inhibits CLK1 and DYRK1A, with IC50 values of 445 nM and 917 nM, respectively [1].

    价 格：￥电议型 号：T60394产 地：中国大陆

  • T60378NAAA-IN-2；化合物 NAAA-IN-2NAAA-IN-2

    NAAA-IN-2 (Compound 9), a potent and selective inhibitor of NAAA, exhibits an IC50 of 50 nM. NAAA, a cysteine amidase, primarily breaks down the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). This compound demonstrates promise for inflammation and pain research [1].

    价 格：￥电议型 号：T60378产 地：中国大陆

  • T60376COQ7-IN-2；化合物 COQ7-IN-2COQ7-IN-2

    COQ7-IN-2 (compound 12) is a COQ7 inhibitor with IC 50 values of 7.3 μM and 15.4 μM for DMQ 10 and UQ 10 accumulation, respectively [1].

    价 格：￥电议型 号：T60376产 地：中国大陆

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