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T1875Atglistatin;化合物AtglistatinAtglistatin
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM.
价 格:¥电议型 号:T1875产 地:中国大陆
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T1867Otenaproxesul;化合物ATB 346ATB 346;ATB 346
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
价 格:¥电议型 号:T1867产 地:中国大陆
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T1866AT-56;化合物AT-56AT-56
AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.
价 格:¥电议型 号:T1866产 地:中国大陆
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T18656S-acetyl-PEG2-Boc化合物S-acetyl-PEG2-BocTert-Butyl 3-[2-(2-Acetylsulfanylethoxy)Ethoxy]Propanoate|||S-A
S-acetyl-PEG2-Boc (S-Acetyl-PEG2-T-Butyl Ester) is a PEG-based PROTAC linker. S-acetyl-PEG2-Boc can be used in the synthesis of PROTACs.
价 格:¥电议型 号:T18656产 地:中国大陆
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T18653S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate;化合物 T18653s-1-hydroxy-2-methylpropan-2-yl-me
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate, an ADC linker, is a glutathione cleavable compound used for the attachment of monoclonal antibodies (mAb) in antibody-drug conjugates (ADCs). It specifically refers to the Alkyl-Chain composition of the linker portion of these molecules [1].
价 格:¥电议型 号:T18653产 地:中国大陆
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T18614Bis-Tos-PEG4化合物Bis-Tos-PEG4Tetraethylene glycol di(p-toluenesulfonate)|||PROTAC Linker 16|||1,11-Bis
Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker. Bis-Tos-PEG4 can be used in the synthesis of PROTACs.
价 格:¥电议型 号:T18614产 地:中国大陆
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T18612Bestatin-amido-Me;化合物 T18612PROTAC IAP binding moiety 1;PROTAC IAP binding moiety 1
Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
价 格:¥电议型 号:T18612产 地:中国大陆
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T18602VH032-thiol-C6-NH2;化合物 T18602VHL Ligand-Linker Conjugates 14|||E3 ligase Ligand-Linker Conjugates 29
VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonly utilized in PROTAC technology.
价 格:¥电议型 号:T18602产 地:中国大陆
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T18595Dasatinib carbaldehyde;化合物Dasatinib carbaldehydePROTAC ABL binding moiety 4|||BMS-354825 carbaldehyd
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].
价 格:¥电议型 号:T18595产 地:中国大陆
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T18592Imatinib carbaldehyde;化合物 T18592CGP-57148B carbaldehyde|||STI571 carbaldehyde|||PROTAC ABL binding m
Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds to the IAP ligand with the assistance of a linker, resulting in the formation of SNIPER[1].
价 格:¥电议型 号:T18592产 地:中国大陆
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T18571m-PEG12-2-methylacrylate;化合物 T18571Propargyl-PEG13-alcohol;Propargyl-PEG13-alcohol
Propargyl-PEG13-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
价 格:¥电议型 号:T18571产 地:中国大陆
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T18559PPC-NHS ester;化合物 T185592,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate;2,5-Dioxopyrrol
PPC-NHS ester is a cleavable linker vital in ADC synthesis. PPC-NHS ester joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
价 格:¥电议型 号:T18559产 地:中国大陆
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T18555Pomalidomide-PEG2-Tos;化合物 T18555Cereblon Ligand-Linker Conjugates 16|||E3 ligase Ligand-Linker Conju
Pomalidomide-PEG2-Tos is a compound that consists of an E3 ligase ligand-linker conjugate. It is composed of a cereblon ligand conjugated to a two-unit PEG linker[1].
价 格:¥电议型 号:T18555产 地:中国大陆
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T18553Pomalidomide-amido-PEG3-C2-NH2;化合物 T18553Cereblon Ligand-Linker Conjugates 22|||E3 ligase Ligand-Lin
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]
价 格:¥电议型 号:T18553产 地:中国大陆
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T18537Pentaethylene glycol di(p-toluenesulfonate)二对甲苯磺酸戊乙二醇Penta(ethylene glycol) bis(p-toluenesulfonate)|
Pentaethylene glycol di(p-toluenesulfonate) (Penta(ethylene glycol) bis(p-toluenesulfonate)) is a PEG-based PROTAC linker. Pentaethylene glycol di(p-toluenesulfonate) can be used in the synthesis of PROTACs.
价 格:¥电议型 号:T18537产 地:中国大陆
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T18529PDEC-NB;化合物PDEC-NB4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate;4-Nitrophenyl 2-(Pyridin-2
PDEC-NB (4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate) is a disulfide cleavable linker. PDEC-NB can be used for the antibody-drug conjugate?(ADC).
价 格:¥电议型 号:T18529产 地:中国大陆
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T18525PC SPDP-NHS carbonate ester;化合物 T18525PC SPDP-NHS carbonate ester
PC SPDP-NHS carbonate ester is a cleavable linker compound utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T18525产 地:中国大陆
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T18523PC Methyltetrazine-PEG4-NHS carbonate ester;化合物 T18523PC Methyltetrazine-PEG4-NHS carbonate ester
PC Methyltetrazine-PEG4-NHS carbonate ester is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
价 格:¥电议型 号:T18523产 地:中国大陆
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T18522PC Mal-NHS carbonate ester;化合物 T18522PC Mal-NHS carbonate ester
PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to antibodies, enabling targeted delivery and enhanced efficacy of therapeutic agents. Its unique carbonate ester structure allows for efficient cleavage in the targeted environment, ensuring the controlled release of the drug payload. Its application in ADC synthesis highlights its imp
价 格:¥电议型 号:T18522产 地:中国大陆
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T1852Rac-Belinostat;化合物BelinostatNSC726630|||PXD101|||PX-105684;NSC726630|||PXD101|||PX-105684
Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
价 格:¥电议型 号:T1852产 地:中国大陆