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T18057K-Ras ligand-Linker Conjugate 4；化合物 T18057K-Ras ligand-Linker Conjugate 4
K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].
价 格：￥电议型 号：T18057产 地：中国大陆
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T18056K-Ras ligand-Linker Conjugate 3；化合物 T18056K-Ras ligand-Linker Conjugate 3
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].
价 格：￥电议型 号：T18056产 地：中国大陆
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T18055K-Ras ligand-Linker Conjugate 2；化合物 T18055K-Ras ligand-Linker Conjugate 2
K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
价 格：￥电议型 号：T18055产 地：中国大陆
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T18054K-Ras ligand-Linker Conjugate 1；化合物 T18054K-Ras ligand-Linker Conjugate 1
K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].
价 格：￥电议型 号：T18054产 地：中国大陆
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T18053Ipatasertib-NH2；化合物 T18053RG7440-NH2|||GDC-0068-NH2；RG7440-NH2|||GDC-0068-NH2
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
价 格：￥电议型 号：T18053产 地：中国大陆
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T1805Ataluren；化合物AtalurenPTC124；PTC124
Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk.
价 格：￥电议型 号：T1805产 地：中国大陆
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T1799Caspofungin Acetate；醋酸卡泊芬净L 743873|||Cancidas|||MK 0991|||L 743872；醋酸卡泊芬净|||L 743873|||Cancidas|||MK
Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. This agent is active against Aspergillus and Candida species.
价 格：￥电议型 号：T1799产 地：中国大陆
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T17984Folate-PEG3-azide；化合物 T17984Folate-PEG3-azide
Folate-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T17984产 地：中国大陆
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T1797Cabozantinib S-malate；卡博替尼苹果酸盐Cabozantinib|||XL184|||Cabozantinib Malate；苹果酸卡博替尼|||Cabozantinib|||卡博
Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity.
价 格：￥电议型 号：T1797产 地：中国大陆
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T17943FAK ligand-Linker Conjugate 1；化合物 T17943FAK ligand-Linker Conjugate 1
FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].
价 格：￥电议型 号：T17943产 地：中国大陆
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T17941ERRα Ligand-Linker Conjugates 1；化合物 T17941ERRα Ligand-Linker Conjugates 1
ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].
价 格：￥电议型 号：T17941产 地：中国大陆
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T1792LRegorafenib monohydrate；瑞格非尼一水合物Regorafenib monohydrate
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respectively.
价 格：￥电议型 号：T1792L产 地：中国大陆
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T17928Lenalidomide-C5-NH2；化合物 T17928E3 ligase Ligand-Linker Conjugates 31|||Cereblon Ligand-Linker Conjuga
Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].
价 格：￥电议型 号：T17928产 地：中国大陆
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T17926(S,R,S)-AHPC-PEG6-C4-Cl；化合物 T17926VHL Ligand-Linker Conjugates 10|||E3 ligase Ligand-Linker Conjugat
(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
价 格：￥电议型 号：T17926产 地：中国大陆
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T17925(S,R,S)-AHPC-PEG2-NH2化合物(S,R,S)-AHPC-PEG2-NH2VH032-PEG2-NH2|||VHL Ligand-Linker Conjugates 3|||E3 li
(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
价 格：￥电议型 号：T17925产 地：中国大陆
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T17923(S,R,S)-AHPC-PEG3-NH2；化合物 T17923E3 ligase Ligand-Linker Conjugates 5 Free Base|||VH032-PEG3-NH2|||VH
(S,R,S)-AHPC-PEG3-NH2 is a synthetic conjugate of an E3 ligase ligand-linker, incorporating the (S,R,S)-AHPC VHL ligand and a 3-unit PEG linker, which are utilized in PROTAC technology.
价 格：￥电议型 号：T17923产 地：中国大陆
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T17922(S,R,S)-AHPC-PEG3-NH2 hydrochloride；化合物T17922VHL Ligand-Linker Conjugates 1 hydrochloride|||E3 ligas
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC-based VHL ligand and 3-unit PEG linker.
价 格：￥电议型 号：T17922产 地：中国大陆
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T17921(S,R,S)-AHPC-PEG4-N3；化合物T17921VH032-PEG4-N3|||VHL Ligand-Linker Conjugates 5|||E3 ligase Ligand-Link
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.
价 格：￥电议型 号：T17921产 地：中国大陆
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T17920(S,R,S)-AHPC-PEG1-N3；化合物(S,R,S)-AHPC-PEG1-N3VHL Ligand-Linker Conjugates 9|||VH032-PEG1-N3|||E3 liga
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.
价 格：￥电议型 号：T17920产 地：中国大陆
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T17919Thalidomide-O-amido-C6-NH2 TFA；化合物T17919E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate|||Cer
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.
价 格：￥电议型 号：T17919产 地：中国大陆
