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T1782LCanagliflozin hemihydrate；卡格列净半水合物JNJ28431754|||TA 7284|||TA7284|||TA-7284|||JNJ 28431754|||JNJ-2843
Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reabsorption (SGLT1 being responsible for the remaining 10%). Blocking this transporter causes up to 119 grams of blood glucose per day to be eliminated through the urine, corresponding to 476 kilocalories.
价 格：￥电议型 号：T1782L产 地：中国大陆
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T17823Diethylene glycol bis(p-toluenesulfonate)二乙二醇双对甲苯磺酸酯二乙二醇双对甲苯磺酸酯|||Bis-Tos-PEG2|||Diethylene glycol d
Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格：￥电议型 号：T17823产 地：中国大陆
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T17819Thalidomide-O-amido-C8-NH2；化合物 T17819E3 Ligase Ligand-Linker Conjugates 20|||Cereblon Ligand-Linker
Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. This compound is useful in the synthesis of PROTACs, as per reference [1].
价 格：￥电议型 号：T17819产 地：中国大陆
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T17818Thalidomide-O-amido-C4-NH2；化合物 T17818E3 Ligase Ligand-Linker Conjugates 19|||Cereblon Ligand-Linker
Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) is a synthesized ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker. It functions as an E3 ligase ligand-linker conjugate and finds applications in the synthesis of PROTACs[1].
价 格：￥电议型 号：T17818产 地：中国大陆
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T1780LParecoxib sodium帕瑞昔布钠SC 69124A|||SC-69124A|||帕瑞昔布钠|||SC69124A|||Dynastat
Parecoxib is a cyclooxygenase-2 inhibitor used for the short-term treatment of postoperative pain in adults. Parecoxib is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib and rofecoxib. ketorolac has a much higher gastrointestinal toxicity profile compared to most other nonsteroidal anti-inflammatory drugs including ibuprofen and Naprosyn.
价 格：￥电议型 号：T1780L产 地：中国大陆
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T1778AT7519 Hydrochloride；化合物AT 7519 hydrochloride saltAT7519 HCl|||AT 7519 hydrochloride salt；AT7519 HCl
AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
价 格：￥电议型 号：T1778产 地：中国大陆
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T17742DBCO-Biotin；DBCO-生物素Azadibenzocyclooctyne-Biotin conjugate；Azadibenzocyclooctyne-Biotin conjugate
DBCO-Biotin (Azadibenzocyclooctyne-Biotin conjugate) is a PROTAC linker based on the alkyl chain.
价 格：￥电议型 号：T17742产 地：中国大陆
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T17733ATRA-hydroxyimino；化合物 T17733CRABP-II ligand 1；CRABP-II ligand 1
ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1].
价 格：￥电议型 号：T17733产 地：中国大陆
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T1773Afatinib Dimaleate；双马来酸盐阿法替尼BIBW2992|||Afatinib|||BIBW 2992MA2|||Afatinib (BIBW2992) Dimaleate；马来酸阿法
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.
价 格：￥电议型 号：T1773产 地：中国大陆
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T17727CCK2R Ligand-Linker Conjugates 1；化合物 T17727CCK2R Ligand-Linker Conjugates 1
CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1].
价 格：￥电议型 号：T17727产 地：中国大陆
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T1772MDK83190；化合物Apoptosis Activator 2Apoptosis Activator 2；Apoptosis Activator 2
MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
价 格：￥电议型 号：T1772产 地：中国大陆
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T1771Ro 48-8071 fumarate；化合物Ro 48-8071 fumarateRo 48-8071 fumarate
Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
价 格：￥电议型 号：T1771产 地：中国大陆
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T17692Boc-Val-Cit-PAB-PNP；化合物Boc-Val-Cit-PAB-PNPinhibit|||Antibody-drug conjugates linkers|||BocValCitPABP
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
价 格：￥电议型 号：T17692产 地：中国大陆
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T1747LTedizolid phosphate disodium salt；化合物 T1747LTorezolid phosphate sodium salt|||DA 7218|||TR-701|||TR
Tedizolid phosphate is a novel antibacterial prodrug. Tedizolid phosphate is a next-generation oxazolidinone with activity against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp. It also has effective activity against Gram-positive pathogens.
价 格：￥电议型 号：T1747L产 地：中国大陆
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T1746LY-2584702 tosylate salt；化合物LY2584702 tosylateLY2584702 tosylate；LY2584702 tosylate
LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
价 格：￥电议型 号：T1746产 地：中国大陆
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T17454ATP-polyamine-biotin；ATP多胺生物素ATP polyamine biotin|||ATPpolyaminebiotin|||ATP-polyamine-biotin；ATP po
ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.
价 格：￥电议型 号：T17454产 地：中国大陆
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T17424E1rcat；化合物4E1rcat4E1rcat
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
价 格：￥电议型 号：T1742产 地：中国大陆
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T17378Ald-Ph-amido-C2-nitrate；化合物 T17378Ald-Ph-amido-C2-nitrate
Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative primarily employed as a noncleavable ADC linker[1].
价 格：￥电议型 号：T17378产 地：中国大陆
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T17364AhR Ligand-Linker Conjugates 1；化合物 T17364E3 Ligase Ligand-Linker Conjugates 57；E3 Ligase Ligand-Link
AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].
价 格：￥电议型 号：T17364产 地：中国大陆
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T17362Acrylate-PEG-OH (MW 5000)；化合物 T17362Acrylate-PEG-OH (MW 5000)
Acrylate-PEG-OH (MW 5000) is a Polyethylene Glycol (PEG)-based linker compound primarily utilized in PROTAC synthesis[1].
价 格：￥电议型 号：T17362产 地：中国大陆
