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  • T74587Phenylsulfamide；化合物 PhenylsulfamidePhenylsulfamide

    Phenylsulfamide (Compound 10), acting as an inhibitor of human carbonic anhydrase-II (hCA-II), exhibits a dissociation constant (Kd) of 45.50 μM and an inhibition constant (Ki) of 79.60 μM [1].

    价 格：￥电议型 号：T74587产 地：中国大陆

  • T745855-Methylcytidine 5′-triphosphate trisodium；化合物 5-Methylcytidine 5′-triphosphate trisodium5-Methylcyt

    5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while reducing innate immune responses in human and mammalian cells when used to replace unmodified mRNA [1].

    价 格：￥电议型 号：T74585产 地：中国大陆

  • T745845-Methylcytidine 5′-triphosphate；化合物 5-Methylcytidine 5′-triphosphate5-Methylcytidine 5′-triphosphat

    5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate immune responses in human and other mammalian cells when substituting unmodified mRNA [1].

    价 格：￥电议型 号：T74584产 地：中国大陆

  • T74583Desmethylazelastine；化合物 DesmethylazelastineDesmethylazelastine

    Desmethylazelastine, the primary active metabolite of Azelastine, undergoes oxidative metabolism via the cytochrome P450 enzyme system, exhibits a 97% protein binding rate, and has an elimination half-life of 54 hours. Azelastine, an orally active, selective, and high-affinity histamine H1-receptor antagonist, is utilized in the research of allergic rhinitis, asthma, diabetic hyperlipidemia, and SARS-CoV-2 [1] [2] [3] [4] [5].

    价 格：￥电议型 号：T74583产 地：中国大陆

  • T74582Trimipramine N-oxide；化合物 Trimipramine N-oxideTrimipramine N-oxide

    Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. It is utilized in the research of depression and anxiety [1].

    价 格：￥电议型 号：T74582产 地：中国大陆

  • T74581TCL053；化合物 TCL053TCL053

    TCL053, an ionizable lipid carrier, efficiently facilitates the introduction of active components, particularly nucleic acids, into cells. In combination with Dipalmitoylphosphatidylcholine (DPPC), Polyethylene glycol dimyristoyl glycerol (PEG-DMG), and cholesterol, TCL053 composes a lipid nanoparticle (LNP) system capable of delivering Cas9 mRNA and sgRNA into skeletal muscle [1] [2].

    价 格：￥电议型 号：T74581产 地：中国大陆

  • T74580SJ1008030；化合物 SJ1008030SJ1008030

    SJ1008030 (compound 8), a JAK2 PROTAC, selectively degrades JAK2. It demonstrates potent activity against MHH–CALL-4 cells, with an EC50 of 5.4 nM and an IC50 of 32.09 nM. This compound holds potential for leukemia research [1].

    价 格：￥电议型 号：T74580产 地：中国大陆

  • T74585-Phenylvaleric Acid；5-苯基戊酸Benzenepentanoic acid|||Phenylvaleric Acid|||Phenylpentanoic acid；Benzene

    5-Phenylvaleric Acid (Benzenepentanoic acid) is a pentanoic acid of bacterial origin, occasionally found in human biofluids.

    价 格：￥电议型 号：T7458产 地：中国大陆

  • T74542YM458；化合物 YM458YM458

    YM458, a potent dual inhibitor of EZH2 and BRD4, exhibits IC50 values of 490 nM and 34 nM, respectively. This compound effectively hinders cell proliferation and colony formation, while also inducing cell cycle arrest and apoptosis in solid tumor cells, making it a viable candidate for anticancer research [1].

    价 格：￥电议型 号：T74542产 地：中国大陆

  • T74458EGFR-IN-43；化合物 EGFR-IN-43EGFR-IN-43

    EGFR-IN-43 (Compound 17c) is a highly effective EGFR inhibitor, exhibiting activity in the single-digit nanomolar range. It uniquely combines tamoxifen or endoxifen with the EGFR inhibitor gefitinib through a covalent bond, maintaining both ER antagonist activity and EGFR inhibition capabilities. This compound demonstrates exceptional anti-cancer efficacy [1].

    价 格：￥电议型 号：T74458产 地：中国大陆

  • T73458LWG-301；化合物 LWG-301LWG-301

    LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.

    价 格：￥电议型 号：T73458产 地：中国大陆

  • T72420MTK458；化合物 MTK458Mitophagy activator 1|||EP-0035985；Mitophagy activator 1|||EP-0035985

    MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson´s disease research.

    价 格：￥电议型 号：T72420产 地：中国大陆

  • T71458Epetraborole；化合物 EpetraboroleEpetraborole

    Epetraborole is a potent and selective leucyl-tRNA synthetase inhibitor. Epetraborole was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens.

    价 格：￥电议型 号：T71458产 地：中国大陆

  • T70458FXIa-6f；化合物 FXIa-6fFXIa-6f

    FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species

    价 格：￥电议型 号：T70458产 地：中国大陆

  • T69458Pirprofen；化合物 PirprofenPirprofen

    Pirprofen is an anti-inflammatory agent used in therapy of rheumatoid arthritis and a prostaglandin synthetase inhibitor.

    价 格：￥电议型 号：T69458产 地：中国大陆

  • T69258PPI-2458；化合物 PPI-2458PPI-2458

    PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.

    价 格：￥电议型 号：T69258产 地：中国大陆

  • T6870L-685458；化合物L-685,458L-685,458；L-685,458

    L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

    价 格：￥电议型 号：T6870产 地：中国大陆

  • T68623RO4583298；化合物 RO4583298RO4583298

    RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity.

    价 格：￥电议型 号：T68623产 地：中国大陆

  • T68458Fostriecin (free base)；化合物 Fostriecin (free base)Fostriecin (free base)

    Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antib

    价 格：￥电议型 号：T68458产 地：中国大陆

  • T67458(E)-3-(4-Chlorophenyl)acrylaldehyde；化合物 (E)-3-(4-Chlorophenyl)acrylaldehyde(E)-3-(4-Chlorophenyl)acr

    (E)-3-(4-Chlorophenyl)acrylaldehyde is a useful organic compound for research related to life sciences. The catalog number is T67458 and the CAS number is 49678-02-6.

    价 格：￥电议型 号：T67458产 地：中国大陆

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