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  • T76463Melittin free acid；化合物 Melittin free acidMelittin free acid

    Melittin free acid, a basic 26-amino-acid polypeptide, constitutes the primary active component of honeybee venom and serves as a phospholipase A2 (PLA2) activator. Exhibiting a broad-spectrum antifungal effect, it presents MIC values ranging from 0.4-60 μM. Its mechanism includes inducing cell apoptosis, inhibiting (1,3)-β-D-glucan synthase, and engaging in multiple pathways [1] [2].

    价 格：￥电议型 号：T76463产 地：中国大陆

  • T75463Tajixanthone；化合物 TajixanthoneTajixanthone

    Tajixanthone is the fungus metabolite from Aspergillus variecolor [1] .

    价 格：￥电议型 号：T75463产 地：中国大陆

  • T74639TT3；化合物 TT3TT3

    TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery [1] [2] .

    价 格：￥电议型 号：T74639产 地：中国大陆

  • T74638XL01126；化合物 XL01126XL01126

    XL01126, a potent degrader of LRRK2, exhibits DC50 values of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. It has the ability to cross the blood-brain barrier, making it a viable degrader probe for Parkinson’s disease research. This compound is instrumental in exploring the non-catalytic and scaffolding functions of LRRK2 [1].

    价 格：￥电议型 号：T74638产 地：中国大陆

  • T74637Sonrotoclax；化合物 SonrotoclaxSonrotoclax

    Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].

    价 格：￥电议型 号：T74637产 地：中国大陆

  • T74636PROTAC BTK Degrader-1；化合物 PROTAC BTK Degrader-1PROTAC BTK Degrader-1

    PROTAC BTK Degrader-1, a powerful, selective, and orally bioavailable degrader of PROTAC BTK, demonstrates effective reduction in BTK protein levels and tumor suppression. It exhibits IC50 values of 34.51 nM for BTK WT and 64.56 nM for BTK-481S, highlighting its potency and efficacy in targeting and diminishing BTK protein abundance [1].

    价 格：￥电议型 号：T74636产 地：中国大陆

  • T74635MS9449；化合物 MS9449MS9449

    MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, and robustly suppresses the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1].

    价 格：￥电议型 号：T74635产 地：中国大陆

  • T74634MS9427 TFA；化合物 MS9427 TFAMS9427 TFA

    MS9427 TFA is a potent PROTAC-based EGFR degrader, exhibiting dissociation constants (Kd) of 7.1 nM for wild-type EGFR and 4.3 nM for the L858R EGFR mutation. It preferentially degrades the mutant EGFR, sparing the wild-type form, utilizing both the ubiquitin/proteasome system (UPS) and the autophagy/lysosome pathways. Its efficacy extends to the significant inhibition of non-small cell lung cancer (NSCLC) cell proliferation, indicating its potential utility in anticancer research [1].

    价 格：￥电议型 号：T74634产 地：中国大陆

  • T74633MS9427；化合物 MS9427MS9427

    MS9427 is a potent PROTAC EGFR degrader, demonstrating high affinity for EGFR with dissociation constants (K d s) of 7.1 nM for the wild-type (WT) EGFR and 4.3 nM for the L858R mutant EGFR, indicating selective degradation of the mutant over the WT EGFR. This degradation occurs through both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. Furthermore, MS9427 effectively inhibits the proliferation of non-small cell lung cancer (NSCLC) cells, positioning it as a potential therape

    价 格：￥电议型 号：T74633产 地：中国大陆

  • T74632TP0556351；化合物 TP0556351TP0556351

    TP0556351, a potent and selective inhibitor of matrix metalloproteinase-2 (MMP2), exhibits significant efficacy with an IC50 of 0.2 nM and demonstrates the capability to decrease collagen accumulation in a Bleomycin-induced pulmonary fibrosis mouse model. This compound shows promise as a research tool for idiopathic pulmonary fibrosis (IPF) [1].

    价 格：￥电议型 号：T74632产 地：中国大陆

  • T74631RNA polymerase II-IN-2；化合物 RNA polymerase II-IN-2RNA polymerase II-IN-2

    RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α-amanitin in CHO and HEK293 cells, respectively [1].

    价 格：￥电议型 号：T74631产 地：中国大陆

  • T74630RNA polymerase II-IN-1；化合物 RNA polymerase II-IN-1RNA polymerase II-IN-1

    RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells compared to α-Amanitin [1].

    价 格：￥电议型 号：T74630产 地：中国大陆

  • T73463NX-2127；化合物NX-2127NX2127|||NX 2127；NX2127|||NX 2127

    NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells.

    价 格：￥电议型 号：T73463产 地：中国大陆

  • T73333OICR12694；化合物 OICR12694JNJ-65234637；JNJ-65234637

    OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6) [1] .

    价 格：￥电议型 号：T73333产 地：中国大陆

  • T71546SC-44463；化合物 SC-44463SC-44463

    SC-44463 is an MMP inhibitor, also a collagenase inhibitor , and HDAC inhibitor.

    价 格：￥电议型 号：T71546产 地：中国大陆

  • T71463MCN-5652W68 perchlorate；化合物 MCN-5652W68 perchlorateMCN-5652W68 perchlorate

    MCN-5652W68 perchlorate is a serotonin uptake inhibitor.

    价 格：￥电议型 号：T71463产 地：中国大陆

  • T70463FCE-27164；化合物 FCE-27164FCE-27164

    FCE-27164 is a therapeutic agent that inhibits platelet-derived growth factor beta and IL-7 binding to their receptors.

    价 格：￥电议型 号：T70463产 地：中国大陆

  • T7017WNK463；化合物WNK463WNK463

    WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).

    价 格：￥电议型 号：T7017产 地：中国大陆

  • T70060PF-06463922 acetate；化合物 PF-06463922 acetatePF-06463922 acetate

    PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).

    价 格：￥电议型 号：T70060产 地：中国大陆

  • T6964Resiquimod；雷西莫特R848|||S28463；R848|||雷西莫特|||S28463

    Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of

    价 格：￥电议型 号：T6964产 地：中国大陆

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