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  • T78579NSC260594;化合物 NSC260594NSC260594

    NSC260594 is a chemical compound that promotes apoptosis by binding to the shallow groove of the Mcl-1 protein and suppressing its expression through down-regulation of Wnt signaling proteins. Additionally, it can identify the G9-G10-A11-G12 RNA tetraloop of HIV, thereby obstructing the attachment of the Gag protein to the 5’-UTR. This compound demonstrates the potential to impede tumor proliferation and is utilized in the study of Triple-negative breast cancers (TNBCs) [1].

    价 格:¥电议型 号:T78579产 地:中国大陆

  • T77903Belantamab mafodotin;化合物 Belantamab mafodotinBelantamab mafodotin-blm|||GSK2857916;Belantamab mafodo

    Belantamab mafodotin (GSK2857916) is a conjugate of a humanized, targeted monoclonal antibody directed against the B cell maturation antigen (BCMA) and the cytotoxic agent McMMAF, exhibiting anti-myeloma activity [1] [2].

    价 格:¥电议型 号:T77903产 地:中国大陆

  • T77579JC2-11;化合物JC2-11JC2-11

    JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate

    价 格:¥电议型 号:T77579产 地:中国大陆

  • T77129Belantamab;贝兰妥单抗GSK2857914;GSK2857914

    Belantamab (GSK2857914) is a humanized IgG1 monoclonal antibody against BCMA (TNFRSF17). Belantamab is a naked antibody to Belantamab mafodotin and can be used to synthesize antibody-active molecule conjugates (Belantamab mafodotin).

    价 格:¥电议型 号:T77129产 地:中国大陆

  • T76579Di-aspartic acid;化合物 Di-aspartic acidDi-aspartic acid

    Di-aspartic acid (Aspartylaspartate) serves as a growth substrate for P. gingivalis, P. intermedia, P. nigrescens, and F. nucleatum [1].

    价 格:¥电议型 号:T76579产 地:中国大陆

  • T7587LTenapanor HCl;化合物 T7587LRDX-5791|||AZD 1722|||AZD-1722|||AZD1722|||RDX5791|||RDX 5791;RDX-5791|||AZD

    Tenapanor( AZD-1722, RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which is used for sodium handling in the gastrointestinal tract and kidney.

    价 格:¥电议型 号:T7587L产 地:中国大陆

  • T7587Tenapanor;化合物TenapanorRDX-5791|||RDX 5791|||AZD 1722|||Tenapanor free base|||RDX5791|||AZD-1722|||AZ

    Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects.

    价 格:¥电议型 号:T7587产 地:中国大陆

  • T75799Hemopressin(human, mouse) TFA;化合物 Hemopressin(human, mouse) TFAHemopressin(human, mouse) TFA

    Hemopressin TFA, a nonapeptide originating from the α1-chain of hemoglobin and initially isolated from rat brain homogenates, is an orally active, selective inverse agonist of CB1 cannabinoid receptors that demonstrates antinociceptive effects in inflammatory pain models [1] [2].

    价 格:¥电议型 号:T75799产 地:中国大陆

  • T75798Hemopressin(rat) TFA;化合物 Hemopressin(rat) TFAHemopressin(rat) TFA

    Hemopressin(rat) TFA, a nonapeptide originating from the α1-chain of hemoglobin, was first isolated from rat brain homogenates. It acts as an orally active, selective, and inverse agonist of the CB1 cannabinoid receptors and demonstrates antinociceptive effects in models of inflammatory pain [1] [2].

    价 格:¥电议型 号:T75798产 地:中国大陆

  • T75797β-Pompilidotoxin TFA;化合物 β-Pompilidotoxin TFAβ-Pompilidotoxin TFA

    β-Pompilidotoxin TFA (β-PMTX TFA), a component of wasp venom, delays the inactivation of sodium channels and enhances the steady-state sodium current in cells [1].

    价 格:¥电议型 号:T75797产 地:中国大陆

  • T75796Dynamin inhibitory peptide TFA;化合物 Dynamin inhibitory peptide TFADynamin inhibitory peptide TFA

    Dynamin Inhibitory Peptide TFA competitively inhibits the binding of dynamin to amphiphysin, effectively preventing endocytosis. Additionally, this compound impedes the dopamine D3´s influence on GABA A receptors [1].

    价 格:¥电议型 号:T75796产 地:中国大陆

  • T75795Gap 26 TFA;化合物 Gap 26 TFAGap 26 TFA

    Gap 26 TFA, a gap junction blocker, is a connexin mimetic peptide derived from the amino acid sequence 63-75 in the first extracellular loop of connexin 43, featuring the SHVR amino acid motif [1].

    价 格:¥电议型 号:T75795产 地:中国大陆

  • T75794Acetyl-Calpastatin(184-210)(human) TFA;化合物 Acetyl-Calpastatin(184-210)(human) TFAAcetyl-Calpastatin(

    Acetyl-Calpastatin(184-210)(human) TFA, a potent, selective, and reversible inhibitor of calpain, demonstrates Ki values of 0.2 nM for ?-calpain and 6 μM for cathepsin L, indicating high specificity and efficacy in inhibiting these enzymes [1] [2].

    价 格:¥电议型 号:T75794产 地:中国大陆

  • T75793ω-Agatoxin IVA TFA;化合物 ω-Agatoxin IVA TFAω-Agatoxin IVA TFA

    ω-Agatoxin IVA TFA is a potent selective inhibitor of P/Q type Ca2+ (Cav2.1) channels, exhibiting IC50 values of 2 nM for P-type and 90 nM for Q-type channels. It effectively inhibits glutamate exocytosis and calcium influx induced by high potassium, with IC50 ranging from 30 to 225 nM. Additionally, this compound blocks high potassium-induced serotonin and norepinephrine release, while having no impact on L-type or N-type calcium channels [1][2].

    价 格:¥电议型 号:T75793产 地:中国大陆

  • T75792Huwentoxin XVI TFA;化合物 Huwentoxin XVI TFAHuwentoxin XVI TFA

    Huwentoxin XVI TFA, a potent analgesic derived from the Chinese tarantula Ornithoctonus huwena, acts as a highly reversible and selective antagonist of mammalian N-type calcium channels (IC 50 of ~60 nM), with no impact on voltage-gated T-type calcium channels, potassium channels, or sodium channels [1].

    价 格:¥电议型 号:T75792产 地:中国大陆

  • T75791CALP1 TFA;化合物 CALP1 TFACALP1 TFA

    CALP1 TFA, a calmodulin (CaM) agonist with a dissociation constant (Kd) of 88 ?M, selectively binds to the CaM EF-hand/Ca2+-binding site, inhibiting calcium channel opening. This action blocks calcium influx and apoptosis with an IC50 of 44.78 ?M, modulates glutamate receptor channel activity, and impedes a store-operated nonselective cation channel. Additionally, CALP1 TFA enhances CaM-dependent phosphodiesterase activity, denoting its multifaceted role in modulating cellular calcium dynamics [

    价 格:¥电议型 号:T75791产 地:中国大陆

  • T75790CALP2 TFA;化合物 CALP2 TFACALP2 TFA

    CALP2 TFA, a potent calmodulin (CaM) antagonist with a dissociation constant (Kd) of 7.9 ?M, exhibits high affinity for the CaM EF-hand/Ca2+-binding site. This compound effectively inhibits CaM-dependent phosphodiesterase activity and elevates intracellular Ca2+ concentrations. Furthermore, it significantly hinders adhesion and degranulation, while also acting as a robust activator of alveolar macrophages [1] [2] [3] [4].

    价 格:¥电议型 号:T75790产 地:中国大陆

  • T75791-BCP;化合物1-BCPPiperonylic acid piperidide;Piperonylic acid piperidide

    1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.

    价 格:¥电议型 号:T7579产 地:中国大陆

  • T75579UDP-xylose disodium;化合物 UDP-xylose disodiumUDP-xylose disodium

    UDP-xylose disodium is a nature product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a metabolite in the nucleotide sugar metabolism [1] .

    价 格:¥电议型 号:T75579产 地:中国大陆

  • T74579Ferulic acid 4-O-sulfate;化合物 Ferulic acid 4-O-sulfateFerulic acid 4-O-sulfate

    Ferulic Acid 4-O-Sulfate (Ferulic Acid 4-Sulfate), a metabolite of Ferulic Acid, demonstrates vasorelaxant properties and reduces blood pressure in mice [1].

    价 格:¥电议型 号:T74579产 地:中国大陆

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