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T76427(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B；化合物 (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B(D-Pro2,D-Trp6,8,Nle10)
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B functions as a competitive antagonist to the Neurokinin B receptor, exhibiting a pA2 value of 5.5. Notably, it does not affect Substance P or Neurokinin A [1].
价 格：￥电议型 号：T76427产 地：中国大陆
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T76426[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)；化合物 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)[Lys5,MeLeu9,Nle10]Ne
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, serves as a selective and potent agonist for the NK2 receptor (NK2R). This compound exhibits prokinetic activity, making it a valuable tool for researching smooth muscle contraction across various tissues through NK-2 receptor engagement [1] [2] [3].
价 格：￥电议型 号：T76426产 地：中国大陆
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T76425(Glu20)-Amyloid β-Protein (1-42)；化合物 (Glu20)-Amyloid β-Protein (1-42)(Glu20)-Amyloid β-Protein (1-42
(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly. This is attributed to the Glu20 mutation, which diminishes Aβ42´s tendency to aggregate and inhibits the accumulation of this slowly fibrillizing peptide. Notably, amyloid β-protein serves as the principal constituent of amyloid deposits found in both the vascular system and brain parenchyma in Alzheimer´s disease [1] [2].
价 格：￥电议型 号：T76425产 地：中国大陆
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T76424(Gly22)-Amyloid β-Protein (1-42)；化合物 (Gly22)-Amyloid β-Protein (1-42)(Gly22)-Amyloid β-Protein (1-42
(Gly22)-Amyloid β-Protein (1-42), a peptide fragment of Amyloid β-Protein (Aβ), plays a crucial role in Alzheimer´s disease by forming the main component of both vascular and parenchymal amyloid deposits. The mutation from Glu22 to Gly22 in Aβ is known to enhance aggregation [1] [2].
价 格：￥电议型 号：T76424产 地：中国大陆
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T76423Neuropeptide AF (cattle)；化合物 Neuropeptide AF (cattle)Neuropeptide AF (cattle)
Neuropeptide AF (cattle), an amidated octadecapeptide and RFamide neuropeptide, serves as a ligand for Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) with an EC50 of approximately 60 nM, and MrgprC11 with an EC50 of around 300 nM. It also activates G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) with an EC50 ranging from ~25 to 325 nM, and NPFF2 with an EC50 of approximately 1 to 5 nM. Furthermore, Neuropeptide AF (cattle) exhibits anti-opiate
价 格：￥电议型 号：T76423产 地：中国大陆
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T76422Protein Kinase C (661-671)；化合物 Protein Kinase C (661-671)Protein Kinase C (661-671)
Protein Kinase C (661-671), a fragment peptide of the β1 subspecies of Protein Kinase C (PKC), is instrumental in regulating cellular growth and has been implicated in tumor promotion [1] [2].
价 格：￥电议型 号：T76422产 地：中国大陆
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T76421Protein Kinase C β Peptide；化合物 Protein Kinase C β PeptideProtein Kinase C β Peptide
Protein Kinase C (beta) Peptide, a fragment of Protein Kinase Cβ, is associated with hyperglycemia-induced decreases in endothelium-derived nitric oxide. Inhibiting Protein Kinase Cβ forestalls the impairment of endothelium-dependent vasodilation caused by acute hyperglycemia [1].
价 格：￥电议型 号：T76421产 地：中国大陆
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T76420Nocistatin；化合物 NocistatinNocistatin
Nocistatin, an endogenous neuropeptide, serves as a ligand for the orphan opioid receptor-like receptor and functionally antagonizes the neuropeptide nociceptin/orphanin FQ (Noc/OFQ). It inhibits 5-HT release through a G i/o protein-mediated pathway and blocks nociceptin-induced allodynia and hyperalgesia [1] [2].
价 格：￥电议型 号：T76420产 地：中国大陆
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T7642Cilostamide；OPC 3689 西洛酰胺OPC3689；OPC3689|||OPC 3689 西洛酰胺
Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)
价 格：￥电议型 号：T7642产 地：中国大陆
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T75642Corydalmine hydrochloride；化合物 Corydalmine hydrochlorideCorydalmine hydrochloride
Corydalmine hydrochloride is a chemical compound that suppresses spore germination in certain plant pathogenic and saprophytic fungi [1], serves as an effective oral analgesic agent with potent activity [2], and mitigates Vincristine-induced neuropathic pain in mice through the inhibition of an NF-κB-dependent CXCL1/CXCR2 signaling pathway [3].
价 格：￥电议型 号：T75642产 地：中国大陆
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T74642DB1113；化合物 DB1113DB1113
DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases. It effectively degrades a range of kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. This capability positions DB1113 as a valuable tool for research into diseases or disorders associated with abe
价 格：￥电议型 号：T74642产 地：中国大陆
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T73642PD-1/PD-L1-IN 3 TFA；化合物 PD-1/PD-L1-IN 3 TFAPD-1/PD-L1-IN 3 TFA
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, serves as a potent and selective inhibitor of PD-1/PD-L1 interaction. This compound disrupts PD-L1´s binding with PD-1 and CD80 by directly binding to PD-L1, exhibiting IC50 values of 5.60 nM and 7.04 nM, respectively. It is utilized in the research of numerous illnesses, such as cancer and infectious diseases [1].
价 格：￥电议型 号：T73642产 地：中国大陆
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T73180NSC 295642；化合物 NSC 295642NSC 295642
NSC 295642, a phosphatase inhibitor, significantly enhances phospho-Erk cytonuclear differences in intact cells, making it a valuable tool for cancer research.
价 格：￥电议型 号：T73180产 地：中国大陆
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T72642Cefepime chloride；化合物 Cefepime chlorideBMY-28142 chloride；BMY-28142 chloride
Cefepime chloride (BMY-28142) is a broad-spectrum cephalosporin capable of crossing the blood-brain barrier, exhibiting antibacterial activity against both Gram-positive and Gram-negative aerobic bacteria. It also induces neurotoxicity.
价 格：￥电议型 号：T72642产 地：中国大陆
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T71642GSK-1562590；化合物 GSK-1562590GSK-1562590
GSK-1562590 is a urotensin-II receptor antagonist.
价 格：￥电议型 号：T71642产 地：中国大陆
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T70642Lanopepden camsylate；化合物 Lanopepden camsylateLanopepden camsylate
Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea
价 格：￥电议型 号：T70642产 地：中国大陆
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T70316AZD6642；化合物 AZD6642AZD6642
AZD6642 is a potential and selective 5-Lipoxygenase activating Protein (FLAP) inhibitor. AZD6642 shows high specific potency and low lipophilicity resulting in a selective and metabolically stable profile. Based on initial PK/PD relations a low dose to human was predicted.
价 格：￥电议型 号：T70316产 地：中国大陆
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T70160PF-06427878；化合物 PF-06427878PF-06427878
PF-06427878 is an orally active, potent and selective diacylglycerol acyltransferase 2 inhibitor.
价 格：￥电议型 号：T70160产 地：中国大陆
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T69642FT385；化合物 FT385FT385
FT385 is a novel USP30 inhibitor, recapitulating genetic loss of USP30 and setting the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
价 格：￥电议型 号：T69642产 地：中国大陆
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T68642Kahweol palmitate；化合物 Kahweol palmitateKahweol palmitate
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
价 格：￥电议型 号：T68642产 地：中国大陆
