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  • T76897Acasunlimab；化合物 AcasunlimabAcasunlimab

    Acasunlimab (GEN1046), a bispecific antibody (bsAb) designed to target PD-L1 and 4-1BB, functions by enhancing both T-cell and NK-cell response via conditional 4-1BB stimulation and continuously inhibiting the PD-1/PD-L1 axis. This compound is applicable in cancer research [1] [2].

    价 格：￥电议型 号：T76897产 地：中国大陆

  • T75897Orphanin FQ(1-11) TFA；化合物 Orphanin FQ(1-11) TFAOrphanin FQ(1-11) TFA

    Orphanin FQ(1-11) TFA, a fragment of orphanin FQ or nociceptin (OFQ/N), acts as a powerful NOP receptor (ORL-1; OP4) agonist, exhibiting a K i of 55 nM. It lacks affinity for μ, δ, κ1, and κ3 receptors (K i >1000 nM), demonstrating its specificity. This compound displays analgesic properties in CD-1 mice [1] [2].

    价 格：￥电议型 号：T75897产 地：中国大陆

  • T7502LPF 05089771；化合物PF-05089771PF-05089771|||PF05089771；PF-05089771|||PF05089771

    PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.

    价 格：￥电议型 号：T7502L产 地：中国大陆

  • T7502PF 05089771 tosylate；化合物PF 05089771 tosylatePF 05089771 tosylate

    PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50: 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50: ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50: 10/20 μM). PF-05089771 is also 1, 000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation o

    价 格：￥电议型 号：T7502产 地：中国大陆

  • T72897P-CAB agent 2；化合物 P-CAB agent 2P-CAB agent 2

    P-CAB Agent 2 is a potent, orally active potassium-competitive acid blocker (P-CAB) and gastric acid secretion inhibitor that effectively inhibits H+/K+-ATPase activity, showing an IC50 value of <100 nM. It also demonstrates inhibition of the hERG potassium channel with an IC50 value of 18.69 M, indicating no acute toxicity. P-CAB Agent 2 effectively curbs histamine-induced gastric acid secretion [1].

    价 格：￥电议型 号：T72897产 地：中国大陆

  • T71897Vatalanib succinate；化合物 Vatalanib succinateVatalanib succinate

    Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.

    价 格：￥电议型 号：T71897产 地：中国大陆

  • T71242AZD-1897；化合物 AZD-1897AZD-1897

    AZD-1897 is an ATP-competitive pan-PIM inhibitor. When combined with the Akt inhibitor AZD5363, AML cells from putative leukaemia stem cells incur a reduction in levels of the anti-apoptotic protein MCL1. The combination of PIM and Akt inhibition holds promise for the treatment of AML.

    价 格：￥电议型 号：T71242产 地：中国大陆

  • T70897Zotiraciclib HCl；化合物 Zotiraciclib HClZotiraciclib HCl

    Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, w

    价 格：￥电议型 号：T70897产 地：中国大陆

  • T69897MC-70 hydrochloride；化合物 MC-70 hydrochlorideMC-70 hydrochloride

    MC-70 hydrochloride is a potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively).

    价 格：￥电议型 号：T69897产 地：中国大陆

  • T69330CJ-14897；化合物 CJ-14897CJ-14897

    CJ-14897 is the (7R,8S)-isomer; a cytokine production inhibitor.

    价 格：￥电议型 号：T69330产 地：中国大陆

  • T68978KU-0058684；化合物 KU-0058684KU-0058684

    KU-0058684 is a potent PARP and DNA-PK inhibitors.

    价 格：￥电议型 号：T68978产 地：中国大陆

  • T68977Picilorex；化合物 PicilorexPicilorex

    Picilorex is a monoamine reuptake inhibitor, a stimulant as well as a derivate of Pyrrolidine.

    价 格：￥电议型 号：T68977产 地：中国大陆

  • T68976Piragliatin；化合物 PiragliatinPiragliatin

    Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in

    价 格：￥电议型 号：T68976产 地：中国大陆

  • T68975Methacholine iodide；化合物 Methacholine iodideMethacholine iodide

    Methacholine iodide is a muscarinic acetylcholine receptor agonist.

    价 格：￥电议型 号：T68975产 地：中国大陆

  • T68974MHY553；化合物 MHY553MHY553

    MHY 553 is a PPARα agonist that improved aged-induced hepatic steatosis.

    价 格：￥电议型 号：T68974产 地：中国大陆

  • T68973EVT-101 free base；化合物 EVT-101 free baseEVT-101 free base

    EVT-101, also known as ENS-101, is an experimental medication which originated from Roche and is under development by Evotec AG for the treatment of major depressive disorder. It acts as a selective NMDA receptor subunit 2B (NR2B) antagonist.

    价 格：￥电议型 号：T68973产 地：中国大陆

  • T68972FR-7534；化合物 FR-7534FR-7534

    FR-7534 is a calcium antagonist structurally similar to nifedipine.

    价 格：￥电议型 号：T68972产 地：中国大陆

  • T68971Ormaplatin；化合物 OrmaplatinOrmaplatin

    Ormaplatin is a platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

    价 格：￥电议型 号：T68971产 地：中国大陆

  • T68970AGN-201781；化合物 AGN-201781AGN-201781

    AGN-201781 is an alpha Adrenoceptor agonist for the treatment of neuropathic pain.

    价 格：￥电议型 号：T68970产 地：中国大陆

  • T6897Monomethyl auristatin E；一甲基澳瑞他汀EVedotin|||MMAE；一甲基澳瑞他汀E|||Vedotin|||MMAE

    Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.

    价 格：￥电议型 号：T6897产 地：中国大陆

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