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T2656FruquintinibFruquintinib,HMPL-013,
Fruquintinib is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities.
价 格:¥电议型 号:T2656产 地:美洲
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T4550AjmalineAjmaline,(+)-Ajmaline,Cardiorythmine
Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.
价 格:¥电议型 号:T4550产 地:美洲
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T4699Hexamethylene amilorideHexamethylene amiloride,5-(N,N-Hexamethylene)amiloride,HMA-5
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 μM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 μM.
价 格:¥电议型 号:T4699产 地:美洲
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T8851I3MT-3;化合物I3MT-3HMPSNE;HMPSNE
I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.
价 格:¥电议型 号:T8851产 地:中国大陆
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T8768MM-102 TFA;化合物MM-102 TFAHMTase Inhibitor IX TFA;HMTase Inhibitor IX TFA
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity. Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer Embry
价 格:¥电议型 号:T8768产 地:中国大陆
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T8758Poziotinib hydrochloride;波齐替尼盐酸盐HM 781-36B hydrochloride|||NOV120101 hydrochloride;HM 781-36B hydroc
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
价 格:¥电议型 号:T8758产 地:中国大陆
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T8668HM03;化合物HM03HM03
HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.
价 格:¥电议型 号:T8668产 地:中国大陆
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T8460Olmutinib;化合物OlmutinibHM61713|||BI1482694;HM61713|||BI1482694
Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
价 格:¥电议型 号:T8460产 地:中国大陆
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T8426Encequidar;化合物EncequidarHM30181|||HM30181A;HM30181|||HM30181A
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
价 格:¥电议型 号:T8426产 地:中国大陆
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T83102Antiarrhythmic peptide (cattle atrium);化合物 Antiarrhythmic peptide (cattle atrium)Antiarrhythmic pept
Antiarrhythmic peptide (cattle atrium), a hexapeptide, exhibits a protective effect against arrhythmias induced by experimental agents [1].
价 格:¥电议型 号:T83102产 地:中国大陆
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T83045Antileishmanial agent-25;化合物 Antileishmanial agent-25Antileishmanial agent-25
Antileishmanial agent-25 (compound 24) exhibits selective activity against intracellular amastigotes, demonstrating an inhibitory concentration (IC50) of 6.63 μM [1].
价 格:¥电议型 号:T83045产 地:中国大陆
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T82222H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe;化合物 H-D-MeAla-Et
H-D-MeAla-EtVal-Val-MeLeu-Ala-D-Ala-MeLeu-MeLeu-MeVal-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe is a derivative of cyclosporin A lacking immunosuppressive properties with potential application in congenital muscular dystrophy research [1].
价 格:¥电议型 号:T82222产 地:中国大陆
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T82189HMGB1-IN-2;化合物 HMGB1-IN-2HMGB1-IN-2
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces IL-1β, TNF-α, and caspase-1 p20 levels, and inhibits NF-κB p65 phosphorylation, providing anti-apoptotic effects. In vivo, HMGB1-IN-2 at a dose of 15 mg/kg administered intraperitoneally alleviates kidney injury in a mouse model of septic acute kidney injury. Furthermore, it inh
价 格:¥电议型 号:T82189产 地:中国大陆
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T81770Mollicellin H;化合物 Mollicellin HMollicellin H
Mollicellin H, a secondary metabolite from the fungus C. brasiliense, exhibits an array of biological activities such as immunomodulation, cytotoxicity, and anti-tumor properties. It demonstrates growth inhibitory effects (GI 50 s) on various human cell lines, including breast cancer (Bre04) at 5.1 μg/mL, lung (Lu04) at 6.5 μg/mL, and neuroma (N04) at 2.5 μg/mL [1].
价 格:¥电议型 号:T81770产 地:中国大陆
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T81301Rehmannioside B;化合物 Rehmannioside BRehmannioside B
Rehmannioside B, a desacyl derivative of Picrorhizaoside B, can be isolated from the methanol extract of Picrorhiza kurroa Royle ex Benth. rhizomes (Plantaginaceae) [1].
价 格:¥电议型 号:T81301产 地:中国大陆
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T80770wt hMLN TFA;化合物 wt hMLN TFAwt hMLN TFA
WT hMLN (TFA) is a microprotein that functions as an inhibitor of the SR Ca2+ pump (SERCA), playing a crucial role in the regulation of calcium homeostasis in skeletal muscle [1].
价 格:¥电议型 号:T80770产 地:中国大陆
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T80556wt hMLN;化合物 wt hMLNwt hMLN
Wild-type human myoregulin (wt hMLN) is a microprotein that inhibits the sarcoplasmic reticulum Ca?? pump (SERCA), playing a crucial role in the regulation of calcium homeostasis in skeletal muscle [1].
价 格:¥电议型 号:T80556产 地:中国大陆
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T80431δ-Theraphotoxin-Hm1a toxin;化合物 δ-Theraphotoxin-Hm1a toxinδ-Theraphotoxin-Hm1a toxin
δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [1].
价 格:¥电议型 号:T80431产 地:中国大陆
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T80430δ-Theraphotoxin-Hm1b;化合物 δ-Theraphotoxin-Hm1bδ-Theraphotoxin-Hm1b
δ-Theraphotoxin-Hm1b, a 42-amino acid peptide derived from the Togo starburst tarantula (Heteroscodra maculata) venom, selectively inhibits the inactivation of NaV1.1 channels without affecting NaV1.7 channels [1].
价 格:¥电议型 号:T80430产 地:中国大陆
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T80429π-TRTX-Hm3a;化合物 π-TRTX-Hm3aπ-TRTX-Hm3a
π-TRTX-Hm3a, a 37-amino acid peptide derived from the venom of the Togo starburst tarantula (Heteroscodra maculata), selectively inhibits the acid-sensing ion channel 1a (ASIC1a) in a pH-dependent manner, with an inhibitory concentration half-max (IC50) of 1-2 nM, and also potentiates the activity of acid-sensing ion channel 1b (ASIC1b) with an effective concentration half-max (EC50) of 46.5 nM [1].
价 格:¥电议型 号:T80429产 地:中国大陆