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  • T69343BZX1；化合物 BZX1BZX1

    BZX1 is a novel inhibitor of O-GlcNAc transferase (OGT) activity.

    价 格：￥电议型 号：T69343产 地：中国大陆

  • T68928GPX100 HCl；化合物 GPX100 HClGPX100 HCl

    GPX-100 is a n analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

    价 格：￥电议型 号：T68928产 地：中国大陆

  • T6839FRAX1036；化合物FRAX1036FRAX1036

    FRAX-1036 is a effective and selective PAK1 inhibitor.

    价 格：￥电议型 号：T6839产 地：中国大陆

  • T6545IOX15-羰基-8-羟基喹啉5-羰基-8-羟基喹啉

    IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively.

    价 格：￥电议型 号：T6545产 地：中国大陆

  • T64000MRTX-EX185；化合物 MRTX-EX185MRTX-EX185

    MRTX-EX185 is an effective inhibitor of GDP-loaded KRAS and KRAS (G12D) with an IC50=90 nM for KRAS (G12D). MRTX-EX185 is also capable of binding GDP-loaded HRAS.

    价 格：￥电议型 号：T64000产 地：中国大陆

  • T63742QTX125 TFA；化合物 QTX125 TFAQTX125 TFA

    QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 has significant selectivity for HDAC6 compared to other HDACs. qTX125 TFA exhibits antitumor activity.

    价 格：￥电议型 号：T63742产 地：中国大陆

  • T63549MRGPRX1 agonist 4；化合物 MRGPRX1 agonist 4MRGPRX1 agonist 4

    MRGPRX1 agonist 4 is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive conformation modulator (EC50: 0.1 μM). MRGPRX1 agonist 4 ameliorated the behavioral thermal allergic response in mice, a model of MRGPRX1 neuropathic pain.

    价 格：￥电议型 号：T63549产 地：中国大陆

  • T63427NRX-103094；化合物NRX-103094NRX103094|||NRX 103094；NRX103094|||NRX 103094

    NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.

    价 格：￥电议型 号：T63427产 地：中国大陆

  • T63075ALOX15-IN-1；化合物 ALOX15-IN-1ALOX15-IN-1

    ALOX15-IN-1 (compound 8b) is a selective and potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, acting on the direct homologues of ALOX15 linoleic acid (LA) (IC50: 0.04 μM) and arachidonic acid (AA) (IC50. 2.06 μM).

    价 格：￥电议型 号：T63075产 地：中国大陆

  • T62773OX11；化合物 OX11OX11

    OX11 is a selective inhibitor of S. pneumoniae, P. aeruginosa and E. coli bacteria.

    价 格：￥电议型 号：T62773产 地：中国大陆

  • T6275Obatoclax Mesylate；奥巴克拉盐酸盐Obatoclax|||GX15-070；Obatoclax|||GX15-070|||奥巴克拉甲磺酸盐

    Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.

    价 格：￥电议型 号：T6275产 地：中国大陆

  • T62606ALOX15-IN-2；化合物ALOX15-IN-2ALOX15-IN-2

    ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respectively.

    价 格：￥电议型 号：T62606产 地：中国大陆

  • T61172NRX-1532；化合物NRX-1532NRX1532|||NRX 1532；NRX1532|||NRX 1532

    NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.

    价 格：￥电议型 号：T61172产 地：中国大陆

  • T61098RUNX1/ETO tetramerization-IN-1；化合物 RUNX1/ETO tetramerization-IN-1RUNX1/ETO tetramerization-IN-1

    RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1/ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully restores gene expression that has been down-regulated by RUNX1/ETO. Furthermore, RUNX1/ETO tetramerization-IN-1 demonstrates promising anti-leukemic activity by inhibiting the proliferation of SKNO-1 cells dependent on RUNX1/ETO and significantly reducing RUNX1/ETO-associated tumor g

    价 格：￥电议型 号：T61098产 地：中国大陆

  • T60497MRGPRX1 agonist 3；化合物 MRGPRX1 agonist 3MRGPRX1 agonist 3

    MRGPRX1 agonist 3 (compound 1f) is a potent positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MRGPRX1) with an EC50 of 0.22 μM. MRGPRX1 agonist 3 can be used for neuropathic pain research[1].

    价 格：￥电议型 号：T60497产 地：中国大陆

  • T60478BTX161；化合物 BTX161BTX161

    BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabilizes the p53 antagonist MDM2[1].

    价 格：￥电议型 号：T60478产 地：中国大陆

  • T60466MRGPRX1 agonist 2；化合物 MRGPRX1 agonist 2MRGPRX1 agonist 2

    MRGPRX1 agonist 2 (compound 1a) is a potent positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MRGPRX1) with an EC 50 value of 0.48 μM. MRGPRX1 agonist 2 has the potential to be used in neuropathic pain research [1].

    价 格：￥电议型 号：T60466产 地：中国大陆

  • T6044Telotristat Etiprate；特罗司他马尿酸盐LX1606 (Hippurate)|||LX 1606 Hippurate；LX1606 (Hippurate)|||LX 1606 Hip

    Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

    价 格：￥电议型 号：T6044产 地：中国大陆

  • T4687Ro5-3335；化合物Ro 5-3335CBFβ-Runx1 inhibitor II|||Ro 5-3335；CBFβ-Runx1 inhibitor II|||Ro 5-3335

    Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.

    价 格：￥电议型 号：T4687产 地：中国大陆

  • T4089FX1；化合物FX1FX1

    FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).

    价 格：￥电议型 号：T4089产 地：中国大陆

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