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T75029HEMTAC CDK4/6 degrader 1；化合物 HEMTAC CDK4/6 degrader 1HEMTAC CDK4/6 degrader 1
HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis . HEMTAC CDK4/6 degrader 1 can be used in research of cancer [1] .
价 格：￥电议型 号：T75029产 地：中国大陆
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T75023Nampt degrader-2；化合物 Nampt degrader-2Nampt degrader-2
Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degradation through the ubiquitin-proteasome system (UPS). This activity significantly lowers NAD+ levels and displays potent antitumor effects [1].
价 格：￥电议型 号：T75023产 地：中国大陆
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T75020PROTAC SOS1 degrader-3；化合物 PROTAC SOS1 degrader-3PROTAC SOS1 degrader-3
PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1].
价 格：￥电议型 号：T75020产 地：中国大陆
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T75017PROTAC HDAC6 degrader 1；化合物 PROTAC HDAC6 degrader 1PROTAC HDAC6 degrader 1
Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].
价 格：￥电议型 号：T75017产 地：中国大陆
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T74982Akt3 degrader 1；化合物 Akt3 degrader 1Akt3 degrader 1
Akt3 Degrader 1 (compound 12l), a selective Akt3 degrader, effectively overcomes Osimertinib-induced resistance in H1975OR NSCLC cells. Besides its role in overcoming drug resistance, it exhibits anti-proliferative properties and significantly hinders tumor growth in mice, making it a valuable tool for researching drug-resistant non-small cell lung cancer [1].
价 格：￥电议型 号：T74982产 地：中国大陆
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T74896PROTAC STING Degrader-1；化合物 PROTAC STING Degrader-1PROTAC STING Degrader-1
PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader exhibiting a DC50 of 3.2 μM and demonstrates anti-inflammatory activity [1].
价 格：￥电议型 号：T74896产 地：中国大陆
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T74857ER degrader 5；化合物 ER degrader 5ER degrader 5
ER Degrader 5 is a potent compound that degrades the estrogen receptor (ER), exhibits anti-proliferation activity, and has potential applications in breast cancer research [1].
价 格：￥电议型 号：T74857产 地：中国大陆
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T74856ER degrader 4；化合物 ER degrader 4ER degrader 4
ER degrader 4, a selective and orally active compound, effectively degrades estrogen receptors and exhibits anti-tumor activity [1].
价 格：￥电议型 号：T74856产 地：中国大陆
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T74853PROTAC CDK9 degrader-7；化合物 PROTAC CDK9 degrader-7PROTAC CDK9 degrader-7
PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (CDK9) through the proteasome pathway [1].
价 格：￥电议型 号：T74853产 地：中国大陆
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T74852PROTAC CDK9 degrader-6；化合物 PROTAC CDK9 degrader-6PROTAC CDK9 degrader-6
PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and CDK9 55 isoforms, respectively [1].
价 格：￥电议型 号：T74852产 地：中国大陆
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T74851PROTAC CDK9 degrader-5；化合物 PROTAC CDK9 degrader-5PROTAC CDK9 degrader-5
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1].
价 格：￥电议型 号：T74851产 地：中国大陆
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T74847PROTAC pan-IAP degrader-1；化合物 PROTAC pan-IAP degrader-1PROTAC pan-IAP degrader-1
PROTAC pan-IAP degrader-1 (Compound 9) is a pan- IAP degrader PROTAC . PROTAC pan-IAP degrader-1 degrades XIAP , cIAP1 and cIAP2 with DC 50 s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively [1] .
价 格：￥电议型 号：T74847产 地：中国大陆
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T74843ITK degrader 1；化合物 ITK degrader 1ITK degrader 1
ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibody in vivo. Additionally, it demonstrates favorable plasma exposure levels [1].
价 格：￥电议型 号：T74843产 地：中国大陆
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T74796PROTAC GPX4 degrader-1；化合物 PROTAC GPX4 degrader-1PROTAC GPX4 degrader-1
PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1].
价 格：￥电议型 号：T74796产 地：中国大陆
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T74732PROTAC PTPN2 degrader-1；化合物 PROTAC PTPN2 degrader-1PROTAC PTPN2 degrader-1
PROTAC PTPN2 Degrader-1 (compound example 77) is a potent entity capable of degrading PTPN2, showing promise for research applications in cancer or metabolic diseases [1].
价 格：￥电议型 号：T74732产 地：中国大陆
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T74707PROTAC FLT3/CDK9 degrader-1；化合物 PROTAC FLT3/CDK9 degrader-1PROTAC FLT3/CDK9 degrader-1
PROTAC FLT3/CDK9 degrader-1, a potent dual degrader of FLT3 and CDK9, effectively induces apoptosis and targets protein degradation of FLT3 and CDK9. This compound holds research potential for FLT3-ITD mutated AML [1].
价 格：￥电议型 号：T74707产 地：中国大陆
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T74636PROTAC BTK Degrader-1；化合物 PROTAC BTK Degrader-1PROTAC BTK Degrader-1
PROTAC BTK Degrader-1, a powerful, selective, and orally bioavailable degrader of PROTAC BTK, demonstrates effective reduction in BTK protein levels and tumor suppression. It exhibits IC50 values of 34.51 nM for BTK WT and 64.56 nM for BTK-481S, highlighting its potency and efficacy in targeting and diminishing BTK protein abundance [1].
价 格：￥电议型 号：T74636产 地：中国大陆
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T74623PROTAC EGFR degrader 7；化合物 PROTAC EGFR degrader 7PROTAC EGFR degrader 7
PROTAC EGFR degrader 7 (compound 13b) is a potent, selective CRBN-recruiting agent targeting EGFR L858R/T790M mutations with a DC50 of 13.2 nM. It effectively inhibits proliferation in NCI–H1975 cells with an IC50 of 46.82 nM and significantly triggers apoptosis and G2/M phase arrest in these cells. Demonstrating antitumor efficacy, PROTAC EGFR degrader 7 holds promise for non-small cell lung cancer (NSCLC) research [1].
价 格：￥电议型 号：T74623产 地：中国大陆
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T74615NAMPT degrader-1；化合物 NAMPT degrader-1NAMPT degrader-1
NAMPT Degrader-1 (Compound A3), a nicotinamide phosphoribosyltransferase (NAMPT) degrader, exhibits potent antitumor activity in cells by specifically inducing the degradation of NAMPT via the autophagy-lysosomal pathway, with an inhibitory concentration (IC50) of 0.023 μM [1].
价 格：￥电议型 号：T74615产 地：中国大陆
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T74614PROTACu00A0Hemagglutininu00A0Degrader-1；化合物 PROTACu00A0Hemagglutininu00A0Degrader-1PROTACu00A0Hemagg
PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent degrader of influenza hemaglutinin (HA), demonstrating a median degradation concentration of 1.44 μM and exhibiting broad-spectrum anti-influenza virus activity [1].
价 格：￥电议型 号：T74614产 地：中国大陆
