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T62052AMPK activator 6；化合物 AMPK activator 6AMPK activator 6
AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (LDL-C), triglyceride (TG), and other biochemical indices in blood serum. AMPK activator 6 has research value in non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome .
价 格：￥电议型 号：T62052产 地：中国大陆
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T62051(R)-(+)-Dimethindene maleate；化合物 (R)-(+)-Dimethindene maleate(R)-(+)-Dimethindene maleate
(R)-(+)-Dimethindene maleate is an orally active H 1 -receptor blocker.
价 格：￥电议型 号：T62051产 地：中国大陆
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T62050Orexin receptor antagonist 4；化合物 Orexin receptor antagonist 4Orexin receptor antagonist 4
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist. Orexin receptor antagonist 4 shows IC50 of 4.27 nM and 295 nM for OX2R and OX1R, respectively.
价 格：￥电议型 号：T62050产 地：中国大陆
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T6205AT7519；化合物AT7519AT7519
AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.
价 格：￥电议型 号：T6205产 地：中国大陆
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T62049CTX-712；化合物 CTX-712CTX-712
CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.
价 格：￥电议型 号：T62049产 地：中国大陆
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T62048Topo I-IN-1；化合物 Topo I-IN-1Topo I-IN-1
Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor. Topo I-IN-1 exhibits antitumor activity and DNA intercalative capability. Topo I-IN-1 can induce cell apoptosis.
价 格：￥电议型 号：T62048产 地：中国大陆
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T62047pan-HER-IN-1；化合物 pan-HER-IN-1pan-HER-IN-1
pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan- HER inhibitor. pan-HER-IN-1 exhibits IC 50s of 0.38, 1.6, 2.2 and 3.5 nM for EGFR, HER4, EGFR T790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and exhibits antitumor activities.
价 格：￥电议型 号：T62047产 地：中国大陆
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T62046HDAC6-IN-5；化合物 HDAC6-IN-5HDAC6-IN-5
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
价 格：￥电议型 号：T62046产 地：中国大陆
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T62044Anticancer agent 71；化合物 Anticancer agent 71Anticancer agent 71
Anticancer agent 71 (Compound 4b) is a potent anticancer agent. Anticancer agent 71 arrests cell cycle at G2/M phase. Anticancer agent 71 induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels.
价 格：￥电议型 号：T62044产 地：中国大陆
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T62043Dyrk1A/B-IN-1；化合物 Dyrk1A/B-IN-1Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable inhibitor of DYRK1A and DYRK1B. Dyrk1A/B-IN-1 inhibits DYRK1A and DYRK1B with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectively.
价 格：￥电议型 号：T62043产 地：中国大陆
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T62042BDZ-g；化合物BDZ-gBDZ-g
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of AMPA receptors.
价 格：￥电议型 号：T62042产 地：中国大陆
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T62041XP5；化合物 XP5XP5
XP5 is a potent, orally active HDAC6 inhibitor (IC50= 31 nM). XP5 inhibits the proliferation of various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM).
价 格：￥电议型 号：T62041产 地：中国大陆
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T62040Tubulin polymerization-IN-30；化合物 Tubulin polymerization-IN-30Tubulin polymerization-IN-30
Tubulin polymerization-IN-30 (compound 6e) is a potent inhibitor of Tubulin polymerization. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including HeLa, SGC-7901 and A549 with IC 50 values of 0.403, 2.16 and 2.21 μM.
价 格：￥电议型 号：T62040产 地：中国大陆
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T6204QNZ；化合物QNZCAY10470|||EVP4593；CAY10470|||EVP4593
QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
价 格：￥电议型 号：T6204产 地：中国大陆
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T6203LSaxagliptin hydrochloride化合物 T6203LBMS477118|||Saxagliptin|||BMS 477118|||Saxagliptin HCl|||BMS-4771
Saxagliptin is a new oral hypoglycemic of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones and reducing fasting and postprandial glucose concentrations in a glucose-dependent manner in patients with type 2 diabetes mellitus.
价 格：￥电议型 号：T6203L产 地：中国大陆
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T62039L-365260 hemihydrate；化合物 L-365260 hemihydrateL-365260 hemihydrate
L-365260 hemihydrate is a selective, orally active non-peptide gastrin and brain cholecystokinin receptor (CCK-B) antagonist, demonstrating competitive interaction with guinea pig stomach gastrin and brain CCK receptors and exhibiting inhibition constants (Kis) of 1.9 nM and 2.0 nM, respectively.
价 格：￥电议型 号：T62039产 地：中国大陆
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T62038CDK2-IN-8；化合物 CDK2-IN-8CDK2-IN-8
CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.
价 格：￥电议型 号：T62038产 地：中国大陆
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T62037BNS-22；化合物 BNS-22BNS-22
BNS-22 is a catalytic inhibitor of DNA topoisomerase II ( TOP2 ). BNS-22 shows the IC 50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and shows anti-proliferative activity.
价 格：￥电议型 号：T62037产 地：中国大陆
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T62036Sovesudil；化合物 SovesudilSovesudil
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor. Sovesudil shows IC50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil can lower intraocular pressure (IOP) without inducing hyperemia.
价 格：￥电议型 号：T62036产 地：中国大陆
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T62035ATR-IN-7；化合物 ATR-IN-7ATR-IN-7
ATR-IN-7 is a potent inhibitor of ATR.
价 格：￥电议型 号：T62035产 地：中国大陆
