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  • T75861ANQ-11125 TFA；化合物 ANQ-11125 TFAANQ-11125 TFA

    ANQ-11125 TFA is a potent, selective motilin antagonist, exhibiting a pKd of 8.24. It effectively inhibits motilide-induced contractions in rabbit models, as demonstrated in vitro [1] [2].

    价 格：￥电议型 号：T75861产 地：中国大陆

  • T75860GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS；化合物 GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPSGTFTSDVSKQMEEEAVRLFIEWL

    GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is an Exendin-4 peptide derivative.

    价 格：￥电议型 号：T75860产 地：中国大陆

  • T7586trifarotene；曲法罗汀CD5789；CD5789|||曲法罗汀

    Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).

    价 格：￥电议型 号：T7586产 地：中国大陆

  • T75859FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS；化合物 FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPSFTSDVSKQMEEEAVRLFIEWLKNGGPS

    FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is an Exendin-4 peptide derivative.

    价 格：￥电议型 号：T75859产 地：中国大陆

  • T75858LL-37, human acetate；化合物 LL-37, human acetateLL-37, human acetate

    LL-37, human acetate, is a 37-residue amphipathic peptide derived from cathelicidin, known for its broad-spectrum antimicrobial properties. This compound not only plays a crucial role in safeguarding the cornea against infection but also modulates wound healing [1] [2] [3].

    价 格：￥电议型 号：T75858产 地：中国大陆

  • T75857LL-37, human TFA；化合物 LL-37, human TFALL-37, human TFA

    LL-37, human TFA, is a cathelicidin-derived, 37-residue, amphipathic antimicrobial peptide that displays a broad spectrum of antimicrobial activity. It may protect the cornea from infection and modulate wound healing [1] [2] [3].

    价 格：￥电议型 号：T75857产 地：中国大陆

  • T75856Huwentoxin-IV TFA；化合物 Huwentoxin-IV TFAHuwentoxin-IV TFA

    Huwentoxin-IV TFA is a potent, selective blocker of sodium channels, specifically inhibiting neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4 with IC50 values of 26, 150, 338, and 400 nM, respectively. It preferentially targets the peripheral nerve subtype Nav1.7 by interacting with neurotoxin receptor site 4, demonstrating analgesic effects in animal models of inflammatory and neuropathic pain [1] [2].

    价 格：￥电议型 号：T75856产 地：中国大陆

  • T75855Phrixotoxin 3 TFA；化合物 Phrixotoxin 3 TFAPhrixotoxin 3 TFA

    Phrixotoxin 3 TFA is a potent inhibitor of voltage-gated sodium channels, demonstrating IC50 values of 0.6 nM for NaV1.2, 42 nM for NaV1.3, 72 nM for NaV1.4, 288 nM for NaV1.1, and 610 nM for NaV1.5, respectively. This compound modulates the activity of these channels similarly to traditional gating-modifier toxins, inducing a depolarizing shift in gating kinetics as well as obstructing the inward sodium current.

    价 格：￥电议型 号：T75855产 地：中国大陆

  • T75854[D-Trp8]-γ-MSH TFA；化合物 [D-Trp8]-γ-MSH TFA[D-Trp8]-γ-MSH TFA

    [D-Trp8]-γ-MSH TFA is a potent, selective agonist for the melanocortin 3 (MC3) receptor, demonstrating IC50 values of 6.7 nM for hMC3, 600 nM for hMC4, and 340 nM for hMC5 in CHO cells, respectively. It shows potential in providing protection against various inflammatory disorders, including rheumatoid arthritis and colitis [1] [2].

    价 格：￥电议型 号：T75854产 地：中国大陆

  • T75853HS014 TFA；化合物 HS014 TFAHS014 TFA

    HS014 TFA, a potent and selective antagonist of the melanocortin-4 (MC4) receptor, exhibits K i values of 3.16, 108, 54.4, and 694 nM for the human MC4, MC1, MC3, and MC5 receptors, respectively. It effectively increases food intake in free-feeding rats [1] [2].

    价 格：￥电议型 号：T75853产 地：中国大陆

  • T75852HS024 TFA；化合物 HS024 TFAHS024 TFA

    HS024, a selective MC4 receptor antagonist, exhibits affinity with Ki values of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1 receptors, respectively. This compound has been shown to increase food intake [1].

    价 格：￥电议型 号：T75852产 地：中国大陆

  • T75851γ1-MSH TFA；化合物 γ1-MSH TFAγ1-MSH TFA

    γ1-MSH TFA, a melanocortin MC3 receptor agonist, demonstrates a binding affinity (K i) of 34 nM for the rat MC3 receptor. Notably, it exhibits approximately 40-fold greater selectivity for the MC3 receptor compared to the MC4 receptor, with a K i of 1318 nM for MC4 [1].

    价 格：￥电议型 号：T75851产 地：中国大陆

  • T75850JKC363 TFA；化合物 JKC363 TFAJKC363 TFA

    JKC363 TFA is a selective melanocortin MC4 receptor antagonist that exhibits a 90-fold higher affinity for the MC4 receptor (IC50=0.5 nM) compared to the MC3 receptor (44.9 nM). This compound effectively inhibits the α-MSH-induced stimulation of TRH release. It also demonstrates an anti-hyperalgesic effect [1] [2].

    价 格：￥电议型 号：T75850产 地：中国大陆

  • T75849Lys-γ3-MSH(human) TFA；化合物 Lys-γ3-MSH(human) TFALys-γ3-MSH(human) TFA

    Lys-γ3-MSH(human) TFA, a melanocortin peptide originating from the C-terminal fragment of pro-opiomelanocortin (POMC), enhances the steroidogenic response of rat adrenal glands to adrenocorticotrophin (ACTH). It is a potent stimulator of lipolysis, demonstrating an apparent EC50 of 3.56 nM, by activating hormone-sensitive lipase (HSL) and Perilipin A, leading to lipolysis [1] [2].

    价 格：￥电议型 号：T75849产 地：中国大陆

  • T75848PG106 TFA；化合物 PG106 TFAPG106 TFA

    PG106 TFA is a potent, selective antagonist of the human melanocortin 3 (hMC3) receptor, displaying an IC50 value of 210 nM, while exhibiting negligible activity at the hMC4 receptors (EC50 = 9900 nM) and hMC5 receptor [1].

    价 格：￥电议型 号：T75848产 地：中国大陆

  • T75847PG-931 TFA；化合物 PG-931 TFAPG-931 TFA

    PG-931 TFA, a potent and selective agonist of the melanocortin 4 (MC4) receptor (IC50=0.58 nM) compared to the hMC3R (IC50=55 nM) and hMC5R (IC50=2.4 nM), is an analog of SHU 9119. This compound has demonstrated efficacy in reversing hemorrhagic shock and preventing multiple organ damage in vivo [2].

    价 格：￥电议型 号：T75847产 地：中国大陆

  • T75846MCH(human, mouse, rat) TFA；化合物 MCH(human, mouse, rat) TFAMCH(human, mouse, rat) TFA

    MCH (human, mouse, rat) TFA is a potent peptide agonist for MCH receptors, demonstrating strong affinity with binding IC 50 values of 0.3 nM for MCH1R and 1.5 nM for MCH2R. It is notably effective against MCH-2R in a CHO cell line, as evidenced by the mobilization of intracellular calcium measured with FLIPR, revealing functional activation EC 50 values of 3.9 nM for MCH-1R and 0.1 nM for MCH-2R [1].

    价 格：￥电议型 号：T75846产 地：中国大陆

  • T75845[Ala17]-MCH TFA；化合物 [Ala17]-MCH TFA[Ala17]-MCH TFA

    [Ala17]-MCH TFA, a selective ligand for MCHR 1 (K i =0.16 nM) over MCHR 2 (K i =34 nM), is an analogue of MCH. When labeled with a [Eu 3+ chelate], [Ala17]-MCH exhibits high affinity for MCHR 1 (K d =0.37 nM) and negligible binding affinity for MCHR 2.

    价 格：￥电议型 号：T75845产 地：中国大陆

  • T75844BIM-23056 TFA；化合物 BIM-23056 TFABIM-23056 TFA

    BIM 23056 TFA, a potent linear octapeptide antagonist of sst3 and sst5 somatostatin receptors, exhibits inhibition constants (K_i) of 10.8 for sst3 and 5.7 for sst5, according to reference [1].

    价 格：￥电议型 号：T75844产 地：中国大陆

  • T75842Cyclosomatostatin TFA；化合物 Cyclosomatostatin TFACyclosomatostatin TFA

    Cyclosomatostatin TFA, a potent somatostatin (SST) receptor antagonist, inhibits type 1 somatostatin receptor (SSTR1) signaling, reducing cell proliferation, the size of the ALDH+ cell population, and sphere-formation in colorectal cancer (CRC) cells [1].

    价 格：￥电议型 号：T75842产 地：中国大陆

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