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  • T74583Desmethylazelastine；化合物 DesmethylazelastineDesmethylazelastine

    Desmethylazelastine, the primary active metabolite of Azelastine, undergoes oxidative metabolism via the cytochrome P450 enzyme system, exhibits a 97% protein binding rate, and has an elimination half-life of 54 hours. Azelastine, an orally active, selective, and high-affinity histamine H1-receptor antagonist, is utilized in the research of allergic rhinitis, asthma, diabetic hyperlipidemia, and SARS-CoV-2 [1] [2] [3] [4] [5].

    价 格：￥电议型 号：T74583产 地：中国大陆

  • T74582Trimipramine N-oxide；化合物 Trimipramine N-oxideTrimipramine N-oxide

    Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. It is utilized in the research of depression and anxiety [1].

    价 格：￥电议型 号：T74582产 地：中国大陆

  • T74581TCL053；化合物 TCL053TCL053

    TCL053, an ionizable lipid carrier, efficiently facilitates the introduction of active components, particularly nucleic acids, into cells. In combination with Dipalmitoylphosphatidylcholine (DPPC), Polyethylene glycol dimyristoyl glycerol (PEG-DMG), and cholesterol, TCL053 composes a lipid nanoparticle (LNP) system capable of delivering Cas9 mRNA and sgRNA into skeletal muscle [1] [2].

    价 格：￥电议型 号：T74581产 地：中国大陆

  • T74580SJ1008030；化合物 SJ1008030SJ1008030

    SJ1008030 (compound 8), a JAK2 PROTAC, selectively degrades JAK2. It demonstrates potent activity against MHH–CALL-4 cells, with an EC50 of 5.4 nM and an IC50 of 32.09 nM. This compound holds potential for leukemia research [1].

    价 格：￥电议型 号：T74580产 地：中国大陆

  • T74585-Phenylvaleric Acid；5-苯基戊酸Benzenepentanoic acid|||Phenylvaleric Acid|||Phenylpentanoic acid；Benzene

    5-Phenylvaleric Acid (Benzenepentanoic acid) is a pentanoic acid of bacterial origin, occasionally found in human biofluids.

    价 格：￥电议型 号：T7458产 地：中国大陆

  • T74558SK-575-NEG；化合物 SK-575-NEGSK-575-NEG

    SK-575-NEG (compound 28), a methylated derivative of SK-575, results from the methylation of the piperidine-2,6-dione´s amino group in SK-575, serving as a control compound. It exhibits strong binding affinity to PARP1, evidenced by an IC50 of 2.64 nM. However, SK-575-NEG proved to be ineffective in promoting PARP1 degradation in MDA-MB-436 and Capan-1 cells, even at concentrations as high as 1 μM [1].

    价 格：￥电议型 号：T74558产 地：中国大陆

  • T74542YM458；化合物 YM458YM458

    YM458, a potent dual inhibitor of EZH2 and BRD4, exhibits IC50 values of 490 nM and 34 nM, respectively. This compound effectively hinders cell proliferation and colony formation, while also inducing cell cycle arrest and apoptosis in solid tumor cells, making it a viable candidate for anticancer research [1].

    价 格：￥电议型 号：T74542产 地：中国大陆

  • T74458EGFR-IN-43；化合物 EGFR-IN-43EGFR-IN-43

    EGFR-IN-43 (Compound 17c) is a highly effective EGFR inhibitor, exhibiting activity in the single-digit nanomolar range. It uniquely combines tamoxifen or endoxifen with the EGFR inhibitor gefitinib through a covalent bond, maintaining both ER antagonist activity and EGFR inhibition capabilities. This compound demonstrates exceptional anti-cancer efficacy [1].

    价 格：￥电议型 号：T74458产 地：中国大陆

  • T74258HL-8；化合物 HL-8HL-8

    HL-8, a PROTAC molecule, effectively targets and degrades PI3K kinase completely at a concentration of 10 μM within 8 hours, showcasing potential for cancer research [1].

    价 格：￥电议型 号：T74258产 地：中国大陆

  • T7420Valifenalate；霜霉灭Valiphenal|||IR5885；霜霉灭|||Valiphenal|||IR5885

    Valifenalate (IR5885) is antifungal agent, effective against various types of mildew

    价 格：￥电议型 号：T7420产 地：中国大陆

  • T74158Aβ Fibrillization modulator 1；化合物 Aβ Fibrillization modulator 1Aβ Fibrillization modulator 1

    Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.

    价 格：￥电议型 号：T74158产 地：中国大陆

  • T74141ARD-2585；化合物 ARD-2585ARD-2585

    ARD-2585 is a highly potent and orally bioavailable proteolysis-targeting chimera (PROTAC) that effectively degrades the androgen receptor [1].

    价 格：￥电议型 号：T74141产 地：中国大陆

  • T73958PROTAC BRD4 Degrader-6；化合物 PROTAC BRD4 Degrader-6PROTAC BRD4 Degrader-6

    PROTAC BRD4 Degrader-6 (compound 32a), a potent small-molecule degrader of BRD4, exhibits an IC50 of 2.7 nM for BRD4 BD1. It effectively degrades BRD4 protein, suppresses c-Myc expression, and inhibits the proliferation of the pancreatic cancer cell line BxPC3 by inducing apoptosis. This compound is applicable in research on human pancreatic cancer [1].

    价 格：￥电议型 号：T73958产 地：中国大陆

  • T73758Glycolithocholic acid 3-sulfate；化合物 Glycolithocholic acid 3-sulfateGlycolithocholic acid 3-sulfate

    Glycolithocholic acid 3-sulfate (SLCG), a cholic acid derivative and glycolithocholic acid metabolite, effectively inhibits HIV-1 replication in vitro. This compound holds potential for researching HIV infection and gallbladder disease [1] [2].

    价 格：￥电议型 号：T73758产 地：中国大陆

  • T7370Talarozole；他拉罗唑R115866；R115866|||他拉罗唑

    Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of acne, psoriasis and other keratinization disorders.

    价 格：￥电议型 号：T7370产 地：中国大陆

  • T73658Orexin A (human, rat, mouse) (acetate)；化合物 Orexin A (human, rat, mouse) (acetate)Orexin A (human, ra

    Orexin A (Hypocretin-1) (human, rat, mouse) acetate, a hypothalamic neuropeptide with analgesic abilities that penetrates the blood-brain barrier, acts as an OX1R agonist. It promotes the expression of BDNF and TH proteins within SH-SY5Y cells, showing both time- and dose-dependent responses. This compound is valuable for researching appetite control, neurodegenerative conditions, and the modulation of detrimental signaling [1] [2] [3].

    价 格：￥电议型 号：T73658产 地：中国大陆

  • T73589DK7575；化合物DK7575DK7575

    DK7575 is a fluorescent dye, a candidate for biological imaging applications, with an appreciable two-photon absorption cross section and strong red light emission.

    价 格：￥电议型 号：T73589产 地：中国大陆

  • T735888-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY；化合物T735888-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY

    8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY is a novel BODIPY fluorescent dye for the treatment of cytotoxicity.

    价 格：￥电议型 号：T73588产 地：中国大陆

  • T73587KT-362 free base；化合物 KT-362 free baseKT-362 free base

    KT-362 is a calcium channel blocker with antihypertensive properties that can be used in the study of cardiovascular disease.

    价 格：￥电议型 号：T73587产 地：中国大陆

  • T73586Anticonvulsant agent 2；抗惊厥剂2Anticonvulsant agent 2

    Anticonvulsant agent 2 is a potent orally active anticonvulsant that has shown antiepileptic activity in a model of drug-resistant epilepsy.

    价 格：￥电议型 号：T73586产 地：中国大陆

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