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  • T73585PU.1-IN-1；化合物PU.1-IN-1PU.1-IN-1

    PU.1-IN-1 is a potent PU.1 inhibitor (IC50 : 2 nM) with anti-inflammatory activity.

    价 格：￥电议型 号：T73585产 地：中国大陆

  • T73582EB1；化合物EB1EB1

    EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.

    价 格：￥电议型 号：T73582产 地：中国大陆

  • T73581HI5；化合物 HI5HI5

    HI5, a potent inhibitor of tubulin and indoleamine 2,3-dioxygenase (IDO), exhibits an inhibitory concentration (IC50) of 70 nM in HeLa cells. It suppresses IDO expression, reduces kynurenine production, and enhances T cell activation and proliferation. Additionally, HI5 impedes tubulin polymerization and cell migration, induces G2/M phase arrest, and leads to apoptosis through the mitochondrial-dependent apoptosis pathway while generating reactive oxidative stress in HeLa cells, making it a valu

    价 格：￥电议型 号：T73581产 地：中国大陆

  • T735808A8；化合物 8A88A8

    8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1].

    价 格：￥电议型 号：T73580产 地：中国大陆

  • T73558W1131；化合物 W1131W1131

    W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PDX). Additionally, W1131 overcomes chemical resistance in cancer cells to 5-FU by regulating cell cycle, DNA damage response, and oxidative phosphorylation pathways, notably the IL6-JAK-STAT3 and ferroptosis pathways [1].

    价 格：￥电议型 号：T73558产 地：中国大陆

  • T73458LWG-301；化合物 LWG-301LWG-301

    LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.

    价 格：￥电议型 号：T73458产 地：中国大陆

  • T73444BRD7586；化合物 BRD7586BRD7586

    BRD7586 represents the smallest known anti-CRISPR, functioning as a cell-permeable, small-molecule inhibitor targeting SpCas9.

    价 格：￥电议型 号：T73444产 地：中国大陆

  • T73358(-)SHIN2；化合物 (-)SHIN2(-)SHIN2

    (-)SHIN2 is the isomer of (+)SHIN2 . (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate in vivo xenotransplantation models [1] .

    价 格：￥电议型 号：T73358产 地：中国大陆

  • T73351CAY10581；化合物 CAY10581CAY10581

    CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50 value of 55 nM.

    价 格：￥电议型 号：T73351产 地：中国大陆

  • T73329MMV676584；化合物 MMV676584MMV676584

    MMV676584 has anti-tuberculosis avtivity. MMV676584 is a novel drug candidate for eumycetoma [1] .

    价 格：￥电议型 号：T73329产 地：中国大陆

  • T73058Cloxacillin化合物 Cloxacillin氯唑西林

    Cloxacillin, an orally active antibacterial agent and β-lactamase inhibitor, exhibits an IC50 of 0.04 ?M. It effectively suppresses S. aureus-induced inflammatory responses by inhibiting the activation of MAPKs, NF-кB, and NLRP3-related proteins.

    价 格：￥电议型 号：T73058产 地：中国大陆

  • T72958BCR-ABL-IN-7；BCR-ABL抑制剂7BCR-ABL-IN-7

    BCR-ABL-IN-7 is a WT and T315I mutant ABL kinase inhibitor.BCR-ABL-IN-7 potently inhibits WT and T315I mutant ABL kinase activity.BCR-ABL-IN-7 can be used in chronic myelogenous leukemia (CML) research.

    价 格：￥电议型 号：T72958产 地：中国大陆

  • T72858Maydispenoid B；化合物 Maydispenoid BMaydispenoid B

    Maydispenoid B, a potent immunosuppressor, effectively inhibits the proliferation of murine splenocytes activated by anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide.

    价 格：￥电议型 号：T72858产 地：中国大陆

  • T72784LOTUB1/USP8-IN-1 HCl；OTUB1/USP8抑制剂1盐酸盐OTUB1/USP8-IN-1 HCl（2858800-98-1 Free base）；OTUB1/USP8-IN-1 HCl

    OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8. OTUB1/USP8-IN-1 may be used in the study of leukaemia.

    价 格：￥电议型 号：T72784L产 地：中国大陆

  • T72658cRIPGBM chloride；化合物 cRIPGBM chloridecRIPGBM chloride

    cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-dependent apoptosis. By inhibiting the formation of the RIPK2/TAK1 prosurvival complex and promoting the assembly of the RIPK2/caspase 1 proapoptotic complex, cRIPGBM chloride efficiently suppresses tumor growth. This action results in significant anti-tumor activity in animal mo

    价 格：￥电议型 号：T72658产 地：中国大陆

  • T72588A3AR antagonist 2；化合物 A3AR antagonist 2A3AR antagonist 2

    A3AR antagonist 2 is a potent antagonist of the human A3 adenosine receptor, exhibiting a Ki value of 4.54 nM.

    价 格：￥电议型 号：T72588产 地：中国大陆

  • T72587BPH-1358 mesylate；化合物 BPH-1358 mesylateNSC50460 mesylate；NSC50460 mesylate

    BPH-1358 mesylate (NSC50460 mesylate), a highly effective inhibitor of both human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS), exhibits IC50 values of 1.8 μM and 110 nM, respectively. Additionally, this compound demonstrates potent in vitro activity against S. aureus, with a minimum inhibitory concentration (MIC) approximately 250 ng/mL.

    价 格：￥电议型 号：T72587产 地：中国大陆

  • T72586Lck Inhibitor III；化合物 Lck Inhibitor IIILck Inhibitor III

    Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM. Additionally, this compound effectively inhibits IL-2 synthesis in Jurkat cells, demonstrating an IC50 of 1.270 μM.

    价 格：￥电议型 号：T72586产 地：中国大陆

  • T72582HIV-1 inhibitor-48；化合物 HIV-1 inhibitor-48HIV-1 inhibitor-48

    HIV-1 inhibitor-48 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity [1] .

    价 格：￥电议型 号：T72582产 地：中国大陆

  • T72581SARS-CoV MPro-IN-2；化合物 SARS-CoV MPro-IN-2SARS-CoV MPro-IN-2

    SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus´s replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing viral polyproteins, M pro is regarded as a key target in drug discovery efforts. Consequently, SARS-CoV MPro-IN-2 holds promise for COVID-19 research.

    价 格：￥电议型 号：T72581产 地：中国大陆

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