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T75140CPD-1224;化合物 CPD-1224CPD-1224
CPD-1224, an orally active derivative that binds cereblon ligands to ALK inhibitors, specifically targets and degrades EML4-ALK oncogenic fusions, including ALK and its mutants L1196M/G1202R.
价 格:¥电议型 号:T75140产 地:中国大陆
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T7514N2-Methylguanosine2-甲鳥苷2-甲鳥苷
N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA´s
价 格:¥电议型 号:T7514产 地:中国大陆
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T74514HD-TAC7;化合物 HD-TAC7HD-TAC7
HD-TAC7, a potent PROTAC HDAC degrader, exhibits IC50 values of 3.6 μM, 4.2 μM, and 1.1 μM for HDAC1, HDAC2, and HDAC3, respectively. It effectively decreases NF-κB p65 in RAW 264.7 macrophages and is utilized in research targeting inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1].
价 格:¥电议型 号:T74514产 地:中国大陆
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T72514MRS2279 diammonium;化合物 MRS2279 diammoniumMRS2279 diammonium
MRS2279 diammonium, a selective and high-affinity P2Y1 receptor antagonist, exhibits a Ki value of 2.5 nM and an IC50 value of 51.6 nM. It competitively inhibits ADP-promoted platelet aggregation, demonstrating a pKb value of 8.05.
价 格:¥电议型 号:T72514产 地:中国大陆
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T71514WYE-23;化合物 WYE-23WYE-23
WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).
价 格:¥电议型 号:T71514产 地:中国大陆
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T70639AM-9514;化合物 AM-9514AM-9514
AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis.
价 格:¥电议型 号:T70639产 地:中国大陆
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T70514Ganciclovir monophosphonate;化合物 Ganciclovir monophosphonateGanciclovir monophosphonate
Ganciclovir monophosphonate is a synthetic analog of 2´-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.
价 格:¥电议型 号:T70514产 地:中国大陆
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T70058PQR514;化合物 PQR514PQR514
PQR514 is a potent pan-PI3K inhibitor (Ki 110alpha =2.2 nM). PQR514 is a follow-up compound for the phase-II clinical compound PQR309. PQR514 has an improved potency both in vitro and in cellular assays with respect to its predecessor compounds. It shows superiority in the suppression of cancer cellproliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309
价 格:¥电议型 号:T70058产 地:中国大陆
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T69514CLE-030;化合物 CLE-030CLE-030
CLE-030 is a KCNQ2 agonist. CLE030 stably binds to the central cavity. Functional analysis, molecular dynamics simulations, and calculations of the potential of mean force revealed that the carbonyl oxygen of CLE030 influences permeant ions in the central cavity to contribute to its activation effects.
价 格:¥电议型 号:T69514产 地:中国大陆
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T69200CGP74514A;化合物 CGP74514ACGP74514A
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and
价 格:¥电议型 号:T69200产 地:中国大陆
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T68514PGN-9856;化合物 PGN-9856PGN-9856
PGN-9856 is a novel potent, selective prostaglandin EP2 receptor agonist
价 格:¥电议型 号:T68514产 地:中国大陆
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T67514Boc-D-Ala-OH;化合物 Boc-D-Ala-OHBoc-D-Ala-OH
Boc-D-Ala-OH is a useful organic compound for research related to life sciences. The catalog number is T67514 and the CAS number is 7764-95-6.
价 格:¥电议型 号:T67514产 地:中国大陆
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T66514(2R,4R)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid;化合物 (2R,4R)-1-(tert-Butoxycarb
(2R,4R)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66514 and the CAS number is 681128-51-8.
价 格:¥电议型 号:T66514产 地:中国大陆
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T65514tert-Butyl ((benzyloxy)carbonyl)-L-tyrosinate;化合物 tert-Butyl ((benzyloxy)carbonyl)-L-tyrosinatetert-
tert-Butyl ((benzyloxy)carbonyl)-L-tyrosinate is a useful organic compound for research related to life sciences. The catalog number is T65514 and the CAS number is 16881-33-7.
价 格:¥电议型 号:T65514产 地:中国大陆
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T65149(E)-Ethyl 3-(pyrrolidin-1-yl)but-2-enoate;化合物 (E)-Ethyl 3-(pyrrolidin-1-yl)but-2-enoate(E)-Ethyl 3-(
(E)-Ethyl 3-(pyrrolidin-1-yl)but-2-enoate is a useful organic compound for research related to life sciences. The catalog number is T65149 and the CAS number is 54716-02-8.
价 格:¥电议型 号:T65149产 地:中国大陆
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T65148Estradiene dione-3-keta;化合物 (8S,13S,14S)-13-Methyl-1,2,6,7,8,12,13,14,15,16-decahydrospiro[cyclopent
Estradiene dione-3-keta is a useful organic compound for research related to life sciences. The catalog number is T65148 and the CAS number is 5571-36-8.
价 格:¥电议型 号:T65148产 地:中国大陆
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T65147Estradiol enanthate;化合物 Estradiol enanthateEstradiol enanthate
Estradiol enanthate is a useful organic compound for research related to life sciences. The catalog number is T65147 and the CAS number is 4956-37-0.
价 格:¥电议型 号:T65147产 地:中国大陆
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T65146Esculin hydrate(2:3);化合物 7-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro
7-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one hydrate(2:3) is a useful organic compound for research related to life sciences and the catalog number is T65146.
价 格:¥电议型 号:T65146产 地:中国大陆
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T65145(S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol;化合物 (S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol(S)-1
(S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T65145 and the CAS number is 225920-05-8.
价 格:¥电议型 号:T65145产 地:中国大陆
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T65144H-D-Val-Obzl.TosOH;化合物 H-D-Val-Obzl.TosOHH-D-Val-Obzl.TosOH
H-D-Val-Obzl.TosOH is an amino acid derivative and has a wide range of applications in life science related research.
价 格:¥电议型 号:T65144产 地:中国大陆