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T78877MTX-241F；化合物 MTX-241FMTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families. It penetrates the blood-brain barrier, providing long-term tumor growth control and exhibits radiosensitizing activity in patient-derived DIPG neurospheres, potentially beneficial for studying diffuse intrinsic pontine glioma (DIPG) [1].
价 格：￥电议型 号：T78877产 地：中国大陆
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T78876DNL343；化合物 DNL343DNL343
DNL343, a brain-penetrating eIF2B (eukaryotic initiation factor 2B) activator, suppresses the abnormal integrated stress response (ISR). By inhibiting ISR activity in the central nervous system (CNS), DNL343 ameliorates neurodegeneration and neuroinflammation. Additionally, it protects against motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice and demonstrates inhibitory potential for vanishing white matter disease (VWMD) characterized by eIF2B LOF and persistent I
价 格：￥电议型 号：T78876产 地：中国大陆
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T78875BTM-3528；化合物 BTM-3528BTM-3528
BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR). It promotes OMA1-dependent cleavage of DELE1 and OPA1, leading to mitochondrial fragmentation. Additionally, BTM-3528 triggers eIF2α kinase HRI activation, resulting in cell growth arrest and apoptosis. Demonstrating anticancer properties, it is effective against various DLBCL cell lines and exhibits in vivo inhibitory capabilities in a mouse model xenografted
价 格：￥电议型 号：T78875产 地：中国大陆
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T78874GSK-3β inhibitor 15；化合物 GSK-3β inhibitor 15GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-induced iNOS expression. It demonstrates neuroprotective properties against Aβ 1-42-induced neurotoxicity, indicating its potential utility in Alzheimer´s disease (AD) research [1].
价 格：￥电议型 号：T78874产 地：中国大陆
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T78873CTL-12；化合物 CTL-12CTL-12
CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apoptotic marker Bcl-xL. By inhibiting de novo lipogenesis, CTL-12 thwarts tumor cells´ metabolic requirements and is frequently employed in breast and colorectal cancer studies [1].
价 格：￥电议型 号：T78873产 地：中国大陆
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T78872CTL-06；化合物 CTL-06CTL-06
CTL-06, a Fatty Acid Synthase (FASN) inhibitor with an IC50 of 3 μM, induces apoptosis, while CTL-12 impedes cell cycle progression in the Sub-G1/S phase and modulates apoptotic and anti-apoptotic markers by upregulating caspase-9 and Bax and downregulating Bcl-xL. Additionally, CTL-12 suppresses de novo lipogenesis, curtailing the metabolic needs of tumor cells, with utilization in breast and colorectal cancer studies [1].
价 格：￥电议型 号：T78872产 地：中国大陆
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T78871PLM-101；化合物 PLM-101PLM-101
PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound´s antitumor efficacy is demonstrated in both a mouse MV4-11 flank xenograft model (doses of 3 and 10 mg/kg; po) and an allogeneic xenograft mouse model (dose of 40 mg/kg; po) [1].
价 格：￥电议型 号：T78871产 地：中国大陆
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T78870TWIK-1/TREK-1-IN-3；TWIK-1/TREK-1抑制剂3TWIK-1/TREK-1-IN-3
TWIK-1/TREK-1-IN-3 is a selective and potent inhibitor of potassium channel TREK-1, inhibiting TREK-1 homodimers and TWIK-1/TREK-1 heterodimers containing two-pore-domain potassium (K2p) channels.TWIK-1/TREK-1-IN-3 exhibits antidepressant activity and can be used in the study of depression.
价 格：￥电议型 号：T78870产 地：中国大陆
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T78878-Hydroxyquinoline hemisulfate；8-羟基喹啉硫酸盐Oxyquinoline sulfate；8-羟基喹啉硫酸盐|||Oxyquinoline sulfate
8-Hydroxyquinoline hemisulfate (Oxyquinoline sulfate) is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action
价 格：￥电议型 号：T7887产 地：中国大陆
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T78869TWIK-1/TREK-1-IN-2；化合物 TWIK-1/TREK-1-IN-2TWIK-1/TREK-1-IN-2
TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values of 10.13 μM and 15.5 μM, respectively. Additionally, it exhibits antidepressant properties [1].
价 格：￥电议型 号：T78869产 地：中国大陆
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T78868TWIK-1/TREK-1-IN-1；化合物 TWIK-1/TREK-1-IN-1TWIK-1/TREK-1-IN-1
Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of 9.36 μM for TREK-1 homodimers and 14.6 μM for TWIK-1/TREK-1 heterodimers, demonstrating antidepressant-like effects [1].
价 格：￥电议型 号：T78868产 地：中国大陆
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T78867WU-04；化合物 WU-04WU-04
WU-04 is a non-covalent inhibitor targeting the 3CLpro protein of SARS-CoV-2, demonstrating high inhibitory effects on 3CLpro from six SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda, and Omicron) as well as two other coronaviruses (SARS-CoV and MERS-CoV) [1].
价 格：￥电议型 号：T78867产 地：中国大陆
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T78866DNA Gyrase-IN-9；化合物 DNA Gyrase-IN-9DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase. It exhibits a minimum inhibitory concentration (MIC) of 0.5-2 ?g/mL for Gram-positive bacteria inhibition and a minimum bactericidal concentration (MBC) of 2-8 ?g/mL for Gram-positive bacteria eradication. Notably, this compound hinders DNA gyrase activity in Staphylococcus aureus with an IC50 of 6.29 ?g/mL [1].
价 格：￥电议型 号：T78866产 地：中国大陆
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T78865α-Glucosidase-IN-34；化合物 α-Glucosidase-IN-34α-Glucosidase-IN-34
α-Glucosidase-IN-34 (compound 7f) is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 2.90 μM, and is applicable in research related to type 2 diabetes and hyperglycemia [1].
价 格：￥电议型 号：T78865产 地：中国大陆
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T78864α-Glucosidase-IN-33；化合物 α-Glucosidase-IN-33α-Glucosidase-IN-33
α-Glucosidase-IN-33 (compound 7c), with an IC50 of 2.39 μM, is a potent inhibitor of α-glucosidase and is relevant in research on type 2 diabetes and hyperglycemia [1].
价 格：￥电议型 号：T78864产 地：中国大陆
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T78863HSP90-IN-25；化合物 HSP90-IN-25HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].
价 格：￥电议型 号：T78863产 地：中国大陆
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T78862EGFR-IN-86；化合物 EGFR-IN-86EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell cycle arrest in U87 cells [1].
价 格：￥电议型 号：T78862产 地：中国大陆
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T78861HDAC8-IN-5；化合物 HDAC8-IN-5HDAC8-IN-5
HDAC8-IN-5 (Compound 6a), with an inhibitory concentration (IC50) of 28 nM, is a potent HDAC8 inhibitor suitable for cancer research [1].
价 格：￥电议型 号：T78861产 地：中国大陆
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T78860MAO-B-IN-24；化合物 MAO-B-IN-24MAO-B-IN-24
MAO-B-IN-24 (compound 11h) is a selective, reversible, competitive inhibitor of MAO-B with an IC50 value of 1.60 μM. It also exhibits inhibitory effects on MAO-A with an IC50 of 22.42 μM. At a concentration of 10 μM, MAO-B-IN-24 reduces the activities of AChE and BChE to 54.58% and 88.43%, respectively [1].
价 格：￥电议型 号：T78860产 地：中国大陆
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T7886Nidufexor；化合物NidufexorNidufexor
Nidufexor is an agonist for the farnesoid X receptor (FXR).
价 格：￥电议型 号：T7886产 地：中国大陆
