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  • T80188Hm1a；化合物 Hm1aHm1a

    Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1].

    价 格：￥电议型 号：T80188产 地：中国大陆

  • T79780IHMT-EZH2-426；化合物 IHMT-EZH2-426IHMT-EZH2-426

    IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effectively inhibits proliferation in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines, attributed to its capacity to diminish H3K27me3 and EZH2 levels [1].

    价 格：￥电议型 号：T79780产 地：中国大陆

  • T79633Antileishmanial agent-22；化合物 Antileishmanial agent-22Antileishmanial agent-22

    Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and tuberculosis. It operates on an antifolate mechanism, suppressing both folic and folinic acids with 88% and 94% efficacy at 100 μM, respectively. This compound also demonstrates a 96.67% inhibitory effect on P. berghei in vivo/in vitro at 48.4 μM/kg/day and 0.038 μM (IC50), and it inhibits M. tuberculosis with an MIC of 28.44 μM [1].

    价 格：￥电议型 号：T79633产 地：中国大陆

  • T79632Antileishmanial agent-21；化合物 Antileishmanial agent-21Antileishmanial agent-21

    Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin. Additionally, it demonstrates inhibitory activity against the chloroquine-resistant Plasmodium falciparum strain RKL9, with an IC50 ranging from 0.0198 to 0.096 μM [1].

    价 格：￥电议型 号：T79632产 地：中国大陆

  • T79520HMG-CoA Reductase-IN-1；化合物 HMG-CoA Reductase-IN-1HMG-CoA Reductase-IN-1

    HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm values of 8.54 and 1.98, respectively. It is utilized in hypercholesterolemia research [1].

    价 格：￥电议型 号：T79520产 地：中国大陆

  • T79471Antileishmanial agent-20；化合物 Antileishmanial agent-20Antileishmanial agent-20

    Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L. infantum and 0.2 μM for L. braziliensis. It is a potential research tool for studying these parasites [1].

    价 格：￥电议型 号：T79471产 地：中国大陆

  • T79449Antileishmanial agent-19；化合物 Antileishmanial agent-19Antileishmanial agent-19

    Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and disrupting the host PI3K/Akt/CREB axis-mediated IL-10 secretion. Additionally, Compound F27 promotes autophagy-mediated apoptosis in L. donovani promastigotes and has been shown to reduce parasite burden in L.d-infected animals [1].

    价 格：￥电议型 号：T79449产 地：中国大陆

  • T79419Antileishmanial agent-24；化合物 Antileishmanial agent-24Antileishmanial agent-24

    Antileishmanial agent-24 (compound 33) exhibits antileishmanial activity, demonstrating an inhibitory concentration 50 (IC50) value of 5.39 μM against amastigotes [1].

    价 格：￥电议型 号：T79419产 地：中国大陆

  • T79390Antileishmanial agent-23；化合物 Antileishmanial agent-23Antileishmanial agent-23

    Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM. It effectively inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei [1].

    价 格：￥电议型 号：T79390产 地：中国大陆

  • T78964Antileishmanial agent-17；化合物 Antileishmanial agent-17Antileishmanial agent-17

    Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine reductase and DHFR-TS. Efficacy against the promastigote form is highlighted by an IC50 value of 0.40 μM, and against the amastigote form, an IC50 of 0.68 μM, respectively.

    价 格：￥电议型 号：T78964产 地：中国大陆

  • T78963Antileishmanial agent-16；化合物 Antileishmanial agent-16Antileishmanial agent-16

    Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 ?M) and amastigotes (IC50 = 0.81 ?M), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1].

    价 格：￥电议型 号：T78963产 地：中国大陆

  • T78962Antileishmanial agent-15；化合物 Antileishmanial agent-15Antileishmanial agent-15

    Antileishmanial agent-15 (compound 13c) exhibits potent activity against L. major promastigotes and amastigotes, demonstrating IC50 values of 0.78 μM for promastigotes and 0.99 μM for amastigotes, while also showing cytotoxicity at these concentrations [1].

    价 格：￥电议型 号：T78962产 地：中国大陆

  • T78836IHMT-PI3K-455；化合物 IHMT-PI3K-455IHMT-PI3K-455

    IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for PI3Kδ. This compound inhibits AKT phosphorylation and promotes tumor regression through the recruitment and activation of CD8+ T cells. It is utilized in cancer research [1].

    价 格：￥电议型 号：T78836产 地：中国大陆

  • T78758IHMT-IDH1-053；化合物 IHMT-IDH1-053IHMT-IDH1-053

    IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-type and mutants. In 293T cells transfected with the IDH1 R132H mutant, IHMT-IDH1-053 reduces 2-hydroxyglutarate (2-HG) production with an IC50 value of 28 nM. The compound engages with the R132H protein at an allosteric site near the NAPDH binding region, forming a covalent link

    价 格：￥电议型 号：T78758产 地：中国大陆

  • T78680Antileishmanial agent-14；化合物 Antileishmanial agent-14Antileishmanial agent-14

    Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by L. donovani amastigotes (IC 50 = 11.1 μM) [1].

    价 格：￥电议型 号：T78680产 地：中国大陆

  • T78311Sontuzumab；松妥组单抗huHMFG-1|||AS1402；huHMFG-1|||AS1402

    Sontuzumab (AS1402), a humanized IgG1κ monoclonal antibody targeting MUC1, exhibits high affinity, with a dissociation constant (Kd) of approximately 1 nM for the extracellular peptide sequence PDTR of MUC1. It is utilized in breast cancer research [1].

    价 格：￥电议型 号：T78311产 地：中国大陆

  • T78232hMAO-B-IN-32；hMAO-B抑制剂32Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate；Ethyl 7-(diethylamino

    hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.

    价 格：￥电议型 号：T78232产 地：中国大陆

  • T78208Leramistat；化合物 LeramistatHMC-C-01-A|||MBS2320；HMC-C-01-A|||MBS2320

    Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune skin diseases, inflammatory disorders, cancer, and osteoclast-mediated diseases [1].

    价 格：￥电议型 号：T78208产 地：中国大陆

  • T78056HMGB1-IN-1；化合物 HMGB1-IN-1HMGB1-IN-1

    HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway. This compound demonstrates promising anti-inflammatory and anti-sepsis properties, particularly in the context of renal injury [1].

    价 格：￥电议型 号：T78056产 地：中国大陆

  • T77752HMBR；化合物HMBR4-Thiazolidinone, 5-[(4-hydroxy-3-methylphenyl)methylene]-2-thioxo-, (5Z)-；4-Thiazolidin

    HMBR are not fluorescent by themselves, but when combined with Y-FAST, they emit yellow light when excited by blue light.

    价 格：￥电议型 号：T77752产 地：中国大陆

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