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  • T70308PLX7683；化合物 PLX7683PLX7683

    PLX7683 is a paradox breaker. Paradox breakers overcame several known mechanisms of resistance to first-generation RAF inhibitors. Dissociating MAPK pathway inhibition from paradoxical activation might yield both improved safety and more durable efficacy than first-generation RAF inhibitors

    价 格：￥电议型 号：T70308产 地：中国大陆

  • T69844NLX-219；化合物 NLX-219NLX-219

    NLX-219 is a selective 5-HT1A receptor-biased agonists.

    价 格：￥电议型 号：T69844产 地：中国大陆

  • T69834Tivumecirnon；化合物 TivumecirnonFLX475；FLX475

    Tivumecirnon (FLX475) is a potent antagonist of CCR4, effectively inhibiting regulatory T cells that hinder antitumor immune responses, thereby demonstrating antitumor activity.

    价 格：￥电议型 号：T69834产 地：中国大陆

  • T69567UCB7362；化合物UCB7362GLXC-26743；GLXC-26743

    UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.

    价 格：￥电议型 号：T69567产 地：中国大陆

  • T6949PLX7904化合物PLX7904PB04

    PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.

    价 格：￥电议型 号：T6949产 地：中国大陆

  • T69412LX-4；化合物 LX-4LX-4

    LX-4 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-4 de-represses a subset of endogenous genes repressed by DNA methylation.

    价 格：￥电议型 号：T69412产 地：中国大陆

  • T69333LX-5；化合物 LX-5LX-5

    LX-5 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-5 de-represses a subset of endogenous genes repressed by DNA methylation.

    价 格：￥电议型 号：T69333产 地：中国大陆

  • T69321LX-3；化合物 LX-3LX-3

    LX-3 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway, which de-represses a subset of endogenous genes repressed by DNA methylation.

    价 格：￥电议型 号：T69321产 地：中国大陆

  • T6867Belumosudil化合物KD025KD025|||Rezurock|||ROCK inhibitor|||SLx-2119

    Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).

    价 格：￥电议型 号：T6867产 地：中国大陆

  • T68337PLX647(OMe)；化合物 PLX647(OMe)PLX647(OMe)

    PLX647(OMe) is a slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility.

    价 格：￥电议型 号：T68337产 地：中国大陆

  • T68096Ly-295501；化合物Ly-295501ILX-295501|||Ly 295501|||Ly295501；ILX-295501|||Ly 295501|||Ly295501

    Ly-295501 (ILX-295501) showed antitumor and anticancer activity in human pancreatic cancer xenotransplantation model.

    价 格：￥电议型 号：T68096产 地：中国大陆

  • T64171LXR antagonist 2；化合物 LXR antagonist 2LXR antagonist 2

    LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 exhibits hypolipidemic activity in Triton WR-1339-induced hyperlipidemic mice.

    价 格：￥电议型 号：T64171产 地：中国大陆

  • T64148LXR agonist 2；化合物 LXR agonist 2LXR agonist 2

    LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR.

    价 格：￥电议型 号：T64148产 地：中国大陆

  • T63989LXRβ agonist-3；化合物 LXRβ agonist-3LXRβ agonist-3

    LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM). LXRβ agonist-3 effectively inhibits U87EGFRvIII cells (IC50: 3.75 μM). .

    价 格：￥电议型 号：T63989产 地：中国大陆

  • T63788PCLX-001；化合物PCLX-001PCLX-001

    PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2].

    价 格：￥电议型 号：T63788产 地：中国大陆

  • T63723LXR agonist 1；化合物 LXR agonist 1LXR agonist 1

    LXR (Liver X receptor) agonist 1 is a potent agonist of LXR, capable of acting on LXR-α (AC50: 1.5 nM) and LXR-β (AC50: 12 nM). LXR agonist 1 has shown research potential in atherosclerosis.

    价 格：￥电议型 号：T63723产 地：中国大陆

  • T63165LX-039；化合物 LX-039LX-039

    LX-039 is a potent, selective, orally active estrogen receptor degrader (EC50: 2.99 nM) with antitumor effects.LX-039 has indole C-3 chloride atoms.LX-039 has good pharmacokinetic properties in mice, low clearance, high blood levels and oral exposure.

    价 格：￥电议型 号：T63165产 地：中国大陆

  • T62929RLX-33；化合物RLX-33RLX-33

    RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats.RLX-33 can be used to study the metabolic syndrome.

    价 格：￥电议型 号：T62929产 地：中国大陆

  • T6273Vadimezan；伐地美生DMXAA|||5,6-Dimethylxanthenone-4-acetic Acid|||NSC 640488|||ASA-404；DMXAA|||伐地美生|||5,6

    Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.

    价 格：￥电议型 号：T6273产 地：中国大陆

  • T62385Befiradol hydrochloride；化合物 Befiradol hydrochlorideNLX-112 hydrochloride|||F 13640 hydrochloride；NLX

    Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-hydroxytryptamine 1A (5-HT)1A receptor agonist with anxiolytic activity.Befiradol hydrochloride inhibits mutant ATXN3 aggregation.

    价 格：￥电议型 号：T62385产 地：中国大陆

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