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T75017PROTAC HDAC6 degrader 1；化合物 PROTAC HDAC6 degrader 1PROTAC HDAC6 degrader 1
Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].
价 格：￥电议型 号：T75017产 地：中国大陆
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T74896PROTAC STING Degrader-1；化合物 PROTAC STING Degrader-1PROTAC STING Degrader-1
PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader exhibiting a DC50 of 3.2 μM and demonstrates anti-inflammatory activity [1].
价 格：￥电议型 号：T74896产 地：中国大陆
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T74853PROTAC CDK9 degrader-7；化合物 PROTAC CDK9 degrader-7PROTAC CDK9 degrader-7
PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (CDK9) through the proteasome pathway [1].
价 格：￥电议型 号：T74853产 地：中国大陆
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T74852PROTAC CDK9 degrader-6；化合物 PROTAC CDK9 degrader-6PROTAC CDK9 degrader-6
PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and CDK9 55 isoforms, respectively [1].
价 格：￥电议型 号：T74852产 地：中国大陆
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T74851PROTAC CDK9 degrader-5；化合物 PROTAC CDK9 degrader-5PROTAC CDK9 degrader-5
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1].
价 格：￥电议型 号：T74851产 地：中国大陆
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T74847PROTAC pan-IAP degrader-1；化合物 PROTAC pan-IAP degrader-1PROTAC pan-IAP degrader-1
PROTAC pan-IAP degrader-1 (Compound 9) is a pan- IAP degrader PROTAC . PROTAC pan-IAP degrader-1 degrades XIAP , cIAP1 and cIAP2 with DC 50 s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively [1] .
价 格：￥电议型 号：T74847产 地：中国大陆
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T74796PROTAC GPX4 degrader-1；化合物 PROTAC GPX4 degrader-1PROTAC GPX4 degrader-1
PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1].
价 格：￥电议型 号：T74796产 地：中国大陆
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T74732PROTAC PTPN2 degrader-1；化合物 PROTAC PTPN2 degrader-1PROTAC PTPN2 degrader-1
PROTAC PTPN2 Degrader-1 (compound example 77) is a potent entity capable of degrading PTPN2, showing promise for research applications in cancer or metabolic diseases [1].
价 格：￥电议型 号：T74732产 地：中国大陆
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T74707PROTAC FLT3/CDK9 degrader-1；化合物 PROTAC FLT3/CDK9 degrader-1PROTAC FLT3/CDK9 degrader-1
PROTAC FLT3/CDK9 degrader-1, a potent dual degrader of FLT3 and CDK9, effectively induces apoptosis and targets protein degradation of FLT3 and CDK9. This compound holds research potential for FLT3-ITD mutated AML [1].
价 格：￥电议型 号：T74707产 地：中国大陆
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T74636PROTAC BTK Degrader-1；化合物 PROTAC BTK Degrader-1PROTAC BTK Degrader-1
PROTAC BTK Degrader-1, a powerful, selective, and orally bioavailable degrader of PROTAC BTK, demonstrates effective reduction in BTK protein levels and tumor suppression. It exhibits IC50 values of 34.51 nM for BTK WT and 64.56 nM for BTK-481S, highlighting its potency and efficacy in targeting and diminishing BTK protein abundance [1].
价 格：￥电议型 号：T74636产 地：中国大陆
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T74623PROTAC EGFR degrader 7；化合物 PROTAC EGFR degrader 7PROTAC EGFR degrader 7
PROTAC EGFR degrader 7 (compound 13b) is a potent, selective CRBN-recruiting agent targeting EGFR L858R/T790M mutations with a DC50 of 13.2 nM. It effectively inhibits proliferation in NCI–H1975 cells with an IC50 of 46.82 nM and significantly triggers apoptosis and G2/M phase arrest in these cells. Demonstrating antitumor efficacy, PROTAC EGFR degrader 7 holds promise for non-small cell lung cancer (NSCLC) research [1].
价 格：￥电议型 号：T74623产 地：中国大陆
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T74614PROTACu00A0Hemagglutininu00A0Degrader-1；化合物 PROTACu00A0Hemagglutininu00A0Degrader-1PROTACu00A0Hemagg
PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent degrader of influenza hemaglutinin (HA), demonstrating a median degradation concentration of 1.44 μM and exhibiting broad-spectrum anti-influenza virus activity [1].
价 格：￥电议型 号：T74614产 地：中国大陆
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T74602PROTAC EZH2 Degrader-1；化合物 PROTAC EZH2 Degrader-1PROTAC EZH2 Degrader-1
PROTAC EZH2 Degrader-1 (Compound 150d), a potent inhibitor, effectively suppresses EZH2 methyltransferase activity, demonstrating an IC50 of 2.7 nM. EZH2 is crucial in various tumorigenesis and development processes [1].
价 格：￥电议型 号：T74602产 地：中国大陆
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T74559PROTAC_ERRα；化合物 PROTAC_ERRαPROTAC_ERRα
PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation. This compound specifically targets ERRα protein, achieving a degradation efficiency of over 80% [1].
价 格：￥电议型 号：T74559产 地：中国大陆
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T74525PROTAC EGFR degrader 6；化合物 PROTAC EGFR degrader 6PROTAC EGFR degrader 6
PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells [1].
价 格：￥电议型 号：T74525产 地：中国大陆
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T74524PROTAC EGFR degrader 5；化合物 PROTAC EGFR degrader 5PROTAC EGFR degrader 5
PROTAC EGFR Degrader 5 (Compound 10), a potent degrader of EGFR Del19 in HCC827 cells, achieves this with a DC50 of 34.8 nM. This compound effectively induces apoptosis in HCC827 cells and causes cell cycle arrest in the G1 phase [1].
价 格：￥电议型 号：T74524产 地：中国大陆
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T74519PROTAC CYP1B1 degrader-1；化合物 PROTAC CYP1B1 degrader-1PROTAC CYP1B1 degrader-1
PROTAC CYP1B1 Degrader-1 (Compound 6C), an α-naphthoflavone chimera derivative, effectively targets and degrades cytochrome P450 (CYP) 1B1 to overcome agent resistance, displaying half-maximal inhibitory concentrations (IC50s) of 95.1 nM for CYP1B1 and 9838.6 nM for CYP1A2. This compound is suitable for investigating prostate cancer characterized by overexpression of CYP1B1 [1].
价 格：￥电议型 号：T74519产 地：中国大陆
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T74518PROTAC VEGFR-2 degrader-2；化合物 PROTAC VEGFR-2 degrader-2PROTAC VEGFR-2 degrader-2
PROTAC VEGFR-2 degrader-2 (PROTAC-4), a specific degrader of VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and low anti-proliferative activity towards EA.hy926 cells (IC50 > 100 μM) [1].
价 格：￥电议型 号：T74518产 地：中国大陆
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T74517PROTAC VEGFR-2 degrader-1；化合物 PROTAC VEGFR-2 degrader-1PROTAC VEGFR-2 degrader-1
PROTAC VEGFR-2 Degrader-1 (PROTAC-1), a specific degrader of PROTAC VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and exhibits low anti-proliferative effects on EA.hy926 cells (IC50 > 100 μM) [1].
价 格：￥电议型 号：T74517产 地：中国大陆
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T74515PROTAC EGFR degrader 4；化合物 PROTAC EGFR degrader 4PROTAC EGFR degrader 4
PROTAC EGFR degrader 4 is a potent molecule designed to target and degrade mutant EGFR, showcasing its effectiveness by inducing degradation of EGFR del19 and EGFR L858R/T790M with DC50 values of 0.51 nM and 126 nM, respectively. Furthermore, it significantly inhibits the growth of HCC827 and H1975 cell lines, demonstrating IC50 values of 0.83 nM and 203.1 nM, respectively. The induced degradation of EGFR by this compound is associated with autophagy [1].
价 格：￥电议型 号：T74515产 地：中国大陆
