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T64258gamma-secretase modulator 5；化合物 gamma-secretase modulator 5gamma-secretase modulator 5
gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60 nM). gamma-secretase modulator 5 can be used in the study of Alzheimer´s disease. The gamma-secretase modulator 5 can be used to study Alzheimer´s disease.
价 格：￥电议型 号：T64258产 地：中国大陆
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T64079Mutant p53 modulator-1；化合物 Mutant p53 modulator-1Mutant p53 modulator-1
Mutant p53 modulator-1 is a mutant p53 modulator. mutant p53 modulator-1 is able to hinder the progression of cancers containing p53 mutations.
价 格：￥电议型 号：T64079产 地：中国大陆
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T640365-HT6R/MAO-B modulator 1；化合物 5-HT6R/MAO-B modulator 15-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 is an antagonist of 5-HT6R at Gs signaling and an irreversible inhibitor of MAO-B that exhibits glial protective activity. 5-HT6R/MAO-B modulator 1 exhibits induction of scopolamine-induced memory deficits.
价 格：￥电议型 号：T64036产 地：中国大陆
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T63964DPP-4/GPR119 modulator 2；化合物 DPP-4/GPR119 modulator 2DPP-4/GPR119 modulator 2
DPP-4/GPR119 modulator 2 is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 0.22 μM) and an agonist of GPR119 (EC50: 0.95 μM).
价 格：￥电议型 号：T63964产 地：中国大陆
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T63745P-gp modulator 3；化合物 P-gp modulator 3P-gp modulator 3
P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.
价 格：￥电议型 号：T63745产 地：中国大陆
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T63678RORγt modulator 2；化合物 RORγt modulator 2RORγt modulator 2
RORγt modulator 2 is a modulator of retinol-related orphan receptor γt (RORyt) (IC50<50 nM) and can be used in the study of RORγt-mediated diseases such as pain, inflammation, asthma, rheumatoid arthritis, COPD, multiple sclerosis, psoriasis, colitis, neurodegenerative diseases and cancer.
价 格：￥电议型 号：T63678产 地：中国大陆
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T63638γ-Secretase modulator 11 hydrochloride；化合物 γ-Secretase modulator 11 hydrochlorideγ-Secretase modulat
γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM). γ-Secretase modulator 11 hydrochloride significantly reduces brain Aβ42 levels and rescues the cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has shown research potential in Alzheimer´s disease.
价 格：￥电议型 号：T63638产 地：中国大陆
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T63609RORγt modulator 3；化合物 RORγt modulator 3RORγt modulator 3
RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis, psoriasis, neurodegenerative diseases and cancer.
价 格：￥电议型 号：T63609产 地：中国大陆
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T63400hA2A/hCA XII modulator 1；化合物 hA2A/hCA XII modulator 1hA2A/hCA XII modulator 1
hA2A/hCA XII modulator 1 is a potent antagonist of the hA2A adenosine receptor (hA2AAR), a triazolopyrazine that acts on hA2AAR (Ki: 6.4 nM), hA1AR (Ki: 4.819 μM), and hA3AR (Ki>30 μM). hA2A/hCA XII modulator 1 Also a potent inhibitor of human carbonic anhydrase XII (hCA XII), capable of acting on hCA XII (Ki: 6.2 nM), hCA II (Ki: 46 nM), hCA IX (Ki: 466 nM) and hCA I (Ki: 8.351 μM). hA2A/hCA XII modulator 1 exhibits potential for cancer research.
价 格：￥电议型 号：T63400产 地：中国大陆
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T63216γ-Secretase modulator 11；化合物 γ-Secretase modulator 11γ-Secretase modulator 11
5-{8-[(3,4´-Difluoro[1,1´-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, was able to cause a significant reduction in brain Aβ42 levels, and had no inhibitory effect on cytochrome p450 enzymes. In addition, compound 1o exhibited excellent anti-cognitive deficits in AD model mice.
价 格：￥电议型 号：T63216产 地：中国大陆
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T63124RORγt modulator 4；化合物 RORγt modulator 4RORγt modulator 4
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen.
价 格：￥电议型 号：T63124产 地：中国大陆
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T63089(R)-IL-17 modulator 4；化合物 (R)-IL-17 modulator 4(R)-IL-17 modulator 4
(R)-IL-17 modulator 4 is the R-configured form of IL-17 modulator 4 and is a prodrug of IL-17 modulator 1. IL-IL-17 modulator 1 is a potent, orally active IL-17 modulator.
价 格：￥电议型 号：T63089产 地：中国大陆
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T63032P-gp modulator 2；化合物 P-gp modulator 2P-gp modulator 2
P-gp modulator 2 (Compound 27) is a potent competitive and metabotropic P-glycoprotein (P-gp) modulator.
价 格：￥电议型 号：T63032产 地：中国大陆
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T62959LRH-1 modulator-1；化合物 LRH-1 modulator-1LRH-1 modulator-1
LRH-1 modulator-1 is a potent modulator/agonist of LRH-1 (liver receptor homolog-1). LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and exhibits inhibition of the inflammatory cytokines IL-1b and TNFa. LRH-1 modulator-1 has anti-inflammatory activity in intestinal-like organs.
价 格：￥电议型 号：T62959产 地：中国大陆
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T62885GABAA receptor modulator-2；化合物 GABAA?receptor?modulator-2GABAA receptor modulator-2
GABAA receptor modulator-2 (Compound 20) is a selective, orally active α5-GABAAR negative conformation modulator (Ki: 4.1 nM). gABAA receptor modulator-2 exhibits high metabolic stability and a good central nervous system safety profile.
价 格：￥电议型 号：T62885产 地：中国大陆
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T62612CD33 splicing modulator 1；化合物 CD33 splicing modulator 1CD33 splicing modulator 1
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial cell activity. CD33 splicing modulator 1 has potential for the study of neurodegenerative diseases, including Alzheimer´s disease.
价 格：￥电议型 号：T62612产 地：中国大陆
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T62406Nur77 modulator 2；化合物 Nur77 modulator 2Nur77 modulator 2
Nur77 modulator 2 is a Nur77 regulator with a Kd value of 0.35 μM. Nur77 modulator 2 is also a potent, orally active inhibitor of inflammation. nur77 modulator 2 regulates Nur77 co-localization in mitochondria.
价 格：￥电议型 号：T62406产 地：中国大陆
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T62352CXCR4 modulator-2；化合物 CXCR4 modulator-2CXCR4 modulator-2
CXCR4 modulator-2 (compound Z7R) is a potent modulator of CXCR4 (IC50: 1.25 nM). CXCR4 modulator-2 exhibits good stability in mouse serum (t1/2= 77.1 min) and has anti-inflammatory effects in a mouse oedema model.
价 格：￥电议型 号：T62352产 地：中国大陆
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T62263γ-Secretase modulator 13；γ-分泌酶调节剂13γ-Secretase modulator 13
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer´s disease and tumors.
价 格：￥电议型 号：T62263产 地：中国大陆
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T62204NR2F6 modulator-1；NR2F6调节剂1NR2F6 modulator-1
NR2F6 modulator-1 is a potent modulator of nuclear receptor subfamily 2, group F, member 6 (NR2F6). NR2F6 modulator-1 can be used to study immune regulation and modulation of tumour stem cell activity.
价 格：￥电议型 号：T62204产 地：中国大陆
