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  • T70580U 93385；化合物 U 93385U 93385

    U 93385 is a 5-hydroxytryptamine (5-HT)1A receptor agonist that has bradycardic effects.

    价 格：￥电议型 号：T70580产 地：中国大陆

  • T7058Selisistat S-enantiomer；(1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺EX-527 S-enantiomer|||EX-527 (S-enantiomer)；E

    Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.

    价 格：￥电议型 号：T7058产 地：中国大陆

  • T7056Dronedarone；决奈达隆SR 33589；决奈达隆|||SR 33589

    Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.

    价 格：￥电议型 号：T7056产 地：中国大陆

  • T70558Org 33201；化合物 Org 33201Org 33201

    Org 33201 is a potent aromatase inhibitor.

    价 格：￥电议型 号：T70558产 地：中国大陆

  • T70539QQN-00358；化合物 QQN-00358QQN-00358

    QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor.

    价 格：￥电议型 号：T70539产 地：中国大陆

  • T70531CGP 55845；化合物 CGP 55845CGP 55845

    CGP 55845 is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively).

    价 格：￥电议型 号：T70531产 地：中国大陆

  • T70458FXIa-6f；化合物 FXIa-6fFXIa-6f

    FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species

    价 格：￥电议型 号：T70458产 地：中国大陆

  • T70370PF-06658607；化合物 PF-06658607PF-06658607

    PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor.

    价 格：￥电议型 号：T70370产 地：中国大陆

  • T70358Gepotidacin mesylate dihydrate；化合物 Gepotidacin mesylate dihydrateGepotidacin mesylate dihydrate

    Gepotidacin mesylate dihydrate, also known as GSK-2140944 mesylate dihydrate, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin mesylate dihydrate is a novel antibacterial drug candidate. Gepotidacin mesylate dihydrate Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin mesylate dihydrate is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution,

    价 格：￥电议型 号：T70358产 地：中国大陆

  • T70340JHU-58；化合物 JHU-58JHU-58

    JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.

    价 格：￥电议型 号：T70340产 地：中国大陆

  • T70338Lu AF58786；化合物 Lu AF58786Lu AF58786

    Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively.

    价 格：￥电议型 号：T70338产 地：中国大陆

  • T70263U 101958；化合物 U 101958U 101958

    U 101958 is a putative antipsychotic agent It is also a highly selective dopamine D4 receptor antagonist.

    价 格：￥电议型 号：T70263产 地：中国大陆

  • T70258Roblitinib citrate；化合物 Roblitinib citrateRoblitinib citrate

    Roblitinib citrate is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) with potential antineoplastic activity.

    价 格：￥电议型 号：T70258产 地：中国大陆

  • T70244JRN73958；化合物 JRN73958JRN73958

    JRN73958 is an important precursor for the synthesis of scytonemin, also called Reduced scytonemin. Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, whi

    价 格：￥电议型 号：T70244产 地：中国大陆

  • T70081Pd 158771；化合物 Pd 158771Pd 158771

    Pd 158771 is a D2 and 5-HT1A agonist.

    价 格：￥电议型 号：T70081产 地：中国大陆

  • T70058PQR514；化合物 PQR514PQR514

    PQR514 is a potent pan-PI3K inhibitor (Ki 110alpha =2.2 nM). PQR514 is a follow-up compound for the phase-II clinical compound PQR309. PQR514 has an improved potency both in vitro and in cellular assays with respect to its predecessor compounds. It shows superiority in the suppression of cancer cellproliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309

    价 格：￥电议型 号：T70058产 地：中国大陆

  • T70048Sch 58053；化合物 Sch 58053Sch 58053

    Sch 58053 is an analog of Ezetimibe and a selective inhibitor of lymphatic cholesterol transport in the intestine.

    价 格：￥电议型 号：T70048产 地：中国大陆

  • T70040BRD5814；化合物 BRD5814BRD5814

    BRD5814 is a highly brain penetrant β-arrestin biased D2R antagonist.

    价 格：￥电议型 号：T70040产 地：中国大陆

  • T6S1587Notoginsenoside R2；三七皂苷R220(S)-Notoginsenoside R2|||Ginsenoside Ng-R2；三七皂苷R2|||20(S)-Notoginsenoside

    Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.

    价 格：￥电议型 号：T6S1587产 地：中国大陆

  • T69958Tofacitinib maleate；化合物 Tofacitinib maleateTofacitinib maleate

    Tofacitinib maleate, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib maleate modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib maleate inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.

    价 格：￥电议型 号：T69958产 地：中国大陆

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