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  • T60413HIF-IN-1；HIF抑制剂1HIF-IN-1

    HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.

    价 格：￥电议型 号：T60413产 地：中国大陆

  • T60410ART-IN-1；化合物 ART-IN-1ART-IN-1

    ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].

    价 格：￥电议型 号：T60410产 地：中国大陆

  • T60408hCA VB-IN-1；化合物 hCA VB-IN-1hCA VB-IN-1

    hCA VB-IN-1 (compound 15) is a potent and selective inhibitor of hCA VB (carbonic anhydrase) with a KI of 515.7 nM [1].

    价 格：￥电议型 号：T60408产 地：中国大陆

  • T60403COX-2/NO-IN-1；化合物 COX-2/NO-IN-1COX-2/NO-IN-1

    COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO ( IC 50 of 3.52 μM) inhibitor as well as suppresses the expression of COX-2. COX-2/NO-IN-1 has anti-inflammatory effects and reduces pathological damage to kidney tissues[1].

    价 格：￥电议型 号：T60403产 地：中国大陆

  • T60381LSD1-IN-12；化合物 LSD1-IN-12LSD1-IN-12

    LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively [1].

    价 格：￥电议型 号：T60381产 地：中国大陆

  • T60379pUL89 Endonuclease-IN-1；化合物 pUL89 Endonuclease-IN-1pUL89 Endonuclease-IN-1

    pUL89 Endonuclease-IN-1 (Compound 13d), with an IC50 value of 0.88 μM, serves as a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease, demonstrating antiviral activity [1].

    价 格：￥电议型 号：T60379产 地：中国大陆

  • T60372ALDH3A1-IN-1；ALDH3A1 抑制剂 1ALDH3A1-IN-1

    ALDH3A1-IN-1 is a small molecule ALDH3A1 inhibitor, (IC50:1.61 μM), which can be used for the study of hyperprolinemia and dry-Larsen syndrome.

    价 格：￥电议型 号：T60372产 地：中国大陆

  • T60364DHODH-IN-17；化合物DHODH-IN-17DHODH-IN-17

    DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemia (AML).

    价 格：￥电议型 号：T60364产 地：中国大陆

  • T60353Glucocerebrosidase-IN-1；化合物 Glucocerebrosidase-IN-1Glucocerebrosidase-IN-1

    Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC 50 of 29.3 μM and a K i of 18.5 μM. Due to GCase involvement in pathological disorders consequent to enzyme deficiency, Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].

    价 格：￥电议型 号：T60353产 地：中国大陆

  • T60346PDE4-IN-10；化合物 PDE4-IN-10PDE4-IN-10

    PDE4-IN-10 (compound 7a) is a potent inhibitor of PDE4, with an IC 50 of 7.01 μM for PDE4B. PDE4-IN-10 exhibits selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro [1].

    价 格：￥电议型 号：T60346产 地：中国大陆

  • T60341Pyruvate Carboxylase-IN-1；化合物 Pyruvate Carboxylase-IN-1Pyruvate Carboxylase-IN-1

    Pyruvate Carboxylase-IN-1 (compound 37), a natural analog of erianin, is a potent inhibitor of pyruvate carboxylase (PC), exhibiting inhibitory concentrations (IC50) of 0.204 μM and 0.104 μM in cell lysate-based and cell-based PC activity assays, respectively. This compound effectively inhibits PC enzymatic activity, contributing to its anticancer effects in human hepatocellular carcinoma (HCC) [1].

    价 格：￥电议型 号：T60341产 地：中国大陆

  • T60339PKN1/2-IN-1；化合物 PKN1/2-IN-1PKN1/2-IN-1

    PKN1/2-IN-1 is a potent, cell penetrant and selective inhibitor of PKN2 /PRK2 with IC50 of 16 nM and Ki of 8 nM [1].

    价 格：￥电议型 号：T60339产 地：中国大陆

  • T60334DYRK1-IN-1；化合物 DYRK1-IN-1DYRK1-IN-1

    DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC 50 value of 220 nM. DYRK1-IN-1 exhibits good permeability and cellular activity without P-glycoprotein liability that can be used for the research of central nervous system penetrant DYRK1A chemical probe [1].

    价 格：￥电议型 号：T60334产 地：中国大陆

  • T60328CDK4/6-IN-12；化合物 CDK4/6-IN-12CDK4/6-IN-12

    CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity against CDK4 and CDK6 with IC 50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used in the cancer research[1].

    价 格：￥电议型 号：T60328产 地：中国大陆

  • T60312FBPase-IN-1；化合物 FBPase-IN-1FBPase-IN-1

    FBPase-IN-1 is a powerful inhibitor of Fructose-1,6-bisphosphatase (FBPase), a key enzyme involved in Type 2 diabetes (T2D) research. It exhibits an impressive IC50 value of 0.22 μM. Aside from its potency, FBPase-IN-1 also demonstrates the ability to effectively lower blood glucose levels and improve glucose tolerance. Its mechanism of action involves covalently modifying the C128 site, thereby influencing the N125-S124-S123 allosteric pathway of FBPase, ultimately impacting its catalytic activ

    价 格：￥电议型 号：T60312产 地：中国大陆

  • T60303Collagen-IN-1；化合物 Collagen-IN-1Collagen-IN-1

    Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1].

    价 格：￥电议型 号：T60303产 地：中国大陆

  • T60295Casein kinase 1δ-IN-1；酪蛋白激酶1δ-IN-1WAY-643895；WAY-643895

    Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ. Casein kinase 1δ-IN-1 can be used in the study of neurodegenerative diseases such as Alzheimer´s disease.

    价 格：￥电议型 号：T60295产 地：中国大陆

  • T60293Estrogen receptor-IN-1；化合物 Estrogen receptor-IN-1Estrogen receptor-IN-1

    Estrogen receptor-IN-1 (compound 16) is an effective estrogen receptor (ER) inhibitor with IC 50 s of 13, 5μM for ERα and Erβ, respectively [1].

    价 格：￥电议型 号：T60293产 地：中国大陆

  • T60274TG-2-IN-1；化合物 TG-2-IN-1TG-2-IN-1

    TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].

    价 格：￥电议型 号：T60274产 地：中国大陆

  • T60255α-Amylase/α-Glucosidase-IN-1；化合物 α-Amylase/α-Glucosidase-IN-1α-Amylase/α-Glucosidase-IN-1

    α-Amylase/α-Glucosidase-IN-1 (compound 33) is an effective inhibitor of α-amylase/α-glucosidase with IC 50 s of 2.01, 2.09 μM for α-amylase and α-glucosidase, respectively. Kinetic studies predict that α-Amylase/α-Glucosidase-IN-1 has the potential of anti hyperglycemia [1].

    价 格：￥电议型 号：T60255产 地：中国大陆

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