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  • T5435ARV-771ARV-771

    ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1].

    价 格：￥电议型 号：T5435产 地：美洲

  • T5618AK-1AK-1

    AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 M).that prevents hippocampal neurodegeneration in Alzheimer´s disease models and induces cell cycle arrest in colon carcinoma cells.

    价 格：￥电议型 号：T5618产 地：美洲

  • T5622AHR antagonist 1AHR antagonist 1

    AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.

    价 格：￥电议型 号：T5622产 地：美洲

  • T6257AZ191AZ191

    AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.

    价 格：￥电议型 号：T6257产 地：美洲

  • T6339AG-14361AG-14361,AG14361,AG 14361

    AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).

    价 格：￥电议型 号：T6339产 地：美洲

  • T6393ARQ 621ARQ 621

    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

    价 格：￥电议型 号：T6393产 地：美洲

  • T6399AZD1981AZD1981

    AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying the treatment and basic science of As

    价 格：￥电议型 号：T6399产 地：美洲

  • T6620OspemifeneOspemifene,FC-1271a,

    Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.

    价 格：￥电议型 号：T6620产 地：美洲

  • T8761[Leu15]-Gastrin I human；化合物T8761Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-

    [Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin.Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system

    价 格：￥电议型 号：T8761产 地：中国大陆

  • T8508HDAC-IN-3；化合物HDAC-IN-3GSK3117391A；GSK3117391A

    HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.

    价 格：￥电议型 号：T8508产 地：中国大陆

  • T8426Encequidar；化合物EncequidarHM30181|||HM30181A；HM30181|||HM30181A

    Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.

    价 格：￥电议型 号：T8426产 地：中国大陆

  • T8408GKT136901；化合物GKT136901AK120765；AK120765

    GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite

    价 格：￥电议型 号：T8408产 地：中国大陆

  • T83950ARN 11391；化合物 ARN 11391ARN 11391

    ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion signaling by directly targeting ITPR1. Furthermore, ARN 11391 amplifies calcium signaling in cells with mutant ITPR1 linked to SCA29, a variant of spinocerebellar ataxia.

    价 格：￥电议型 号：T83950产 地：中国大陆

  • T83908DXR Inhibitor 11a (free acid)；化合物 DXR Inhibitor 11a (free acid)1-Deoxy-D-Xylulose-5-phosphate Reduct

    DXR inhibitor 11a, with an IC50 of 0.11 ?M, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also hampers the growth of P. falciparum in isolated human erythrocytes, demonstrating an IC50 of 0.37 ?M.

    价 格：￥电议型 号：T83908产 地：中国大陆

  • T83885DXR Inhibitor 11a sodium；化合物 DXR Inhibitor 11a sodium1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase

    DXR inhibitor 11a, with an IC50 value of 0.11 ?M, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also demonstrates significant activity against P. falciparum´s growth in isolated human erythrocytes, with an IC50 of 0.37 ?M.

    价 格：￥电议型 号：T83885产 地：中国大陆

  • T83857Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting

    Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = 0.8 nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphoryla

    价 格：￥电议型 号：T83857产 地：中国大陆

  • T83856AP-1；化合物 AP-1AP-1

    AP-1, a miniaturized proteolysis-targeting chimera (PROTAC) incorporating an anaplastic lymphoma kinase (ALK) ligand connected to (±)-thalidomide via an ultrashort linker, effectively degrades ALK fusion proteins such as NPM-ALK in Karpas-299 cells and EML4-ALK and ALKF1174L in SN-N-SH and NCI H3122 cells, respectively. Concentrations ranging from 10 to 300 nM are sufficient for its action, which is hindered by the proteasome inhibitor MG-132. Demonstrating selectivity, AP-1 exhibits cytotoxicit

    价 格：￥电议型 号：T83856产 地：中国大陆

  • T832517-51A；化合物 7-51A7-51A

    7-51A is an effective inhibitor of the PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRP), with a dissociation constant (K_D) of 1.64 nM as determined by isothermal titration calorimetry (ITC).

    价 格：￥电议型 号：T83251产 地：中国大陆

  • T83227A1AT modulator 1；化合物 A1AT modulator 1A1AT modulator 1

    A1AT Modulator 1 potently inhibits Z α1-antitrypsin (A1AT) polymerization, exhibiting a pIC50 of 8.3 [1].

    价 格：￥电议型 号：T83227产 地：中国大陆

  • T83224AADvac 1；化合物 AADvac 1AADvac 1

    AADvac1 is a biologically active peptide functioning as an Alzheimer´s Disease Peptide Vaccine, composed of Tau(294–305) conjugated to Keyhole Limpet Hemocyanin (KLH).

    价 格：￥电议型 号：T83224产 地：中国大陆

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