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T61564PF-03463275;化合物PF-03463275PF-3463275;PF-3463275
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
价 格:¥电议型 号:T61564产 地:中国大陆
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T61463Monoamine oxidase/Aromatase-IN-1;化合物 Monoamine oxidase/Aromatase-IN-1Monoamine oxidase/Aromatase-IN-
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a potent dual inhibitor of monoamine oxidase (MAO) and aromatase, with IC50 values of 39 nM and 31 nM for MAO-B and aromatase, respectively. It holds significant potential for research in neurological disorders and breast cancer [1].
价 格:¥电议型 号:T61463产 地:中国大陆
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T60463Bifemelane;化合物 BifemelaneBifemelane
Bifemelane is a nootropic compound that causes the first peak by stimulating release from intracellular Ca 2+ stores and the second by capacitive entry via store–operated Ca 2+ channels. Bifemelane will be offered as a pharmacological tool for basic research on astrocytes [1].
价 格:¥电议型 号:T60463产 地:中国大陆
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T5463Verdiperstat;化合物AZD3241AZD3241|||AZD 3241;AZD3241|||AZD 3241
Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
价 格:¥电议型 号:T5463产 地:中国大陆
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T5392TP0463518;化合物TP0463518TP0463518
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
价 格:¥电议型 号:T5392产 地:中国大陆
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T4639Azemiglitazone;化合物MSDC 0602MSDC 0602;MSDC 0602
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.
价 格:¥电议型 号:T4639产 地:中国大陆
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T4638E260;化合物Fer and FerT inhibitorFer and FerT inhibitor;Fer and FerT inhibitor
E260 (Fer and FerT inhibitor) is a Fer/FerT kinase inhibitor
价 格:¥电议型 号:T4638产 地:中国大陆
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T4637R-7050;化合物R-7050TNF-α Antagonist III;TNF-α Antagonist III
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.
价 格:¥电议型 号:T4637产 地:中国大陆
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T4636Protein kinase inhibitors 1;化合物Protein kinase inhibitors 1Protein kinase inhibitors 1
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
价 格:¥电议型 号:T4636产 地:中国大陆
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T4635Ralinepag;化合物RalinepagAPD811;APD811
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
价 格:¥电议型 号:T4635产 地:中国大陆
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T4634GNE-6776;化合物GEN6776GEN6776;GEN6776
GNE-6776 is a selective USP7 inhibitor.
价 格:¥电议型 号:T4634产 地:中国大陆
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T4633Asimadoline阿西马朵林EMD-61753|||阿西马朵林
Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kappa opioid receptor agonist. It has shown encouraging clinical efficacy for the treatment of IBS in a barostat study in IBS patients and has the potential for treating other gastrointestinal diseases.
价 格:¥电议型 号:T4633产 地:中国大陆
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T4632NSC 6038;4-氯-N,N-二-N-丙基苯甲酰胺4-chloro-N,N-dipropylbenzamide|||4-Chloro-N,N-di-n-propylbenzaMide;4-chlo
NSC-6038 (4-chloro-N,N-dipropylbenzamide) is a benzamide-based bioactive compound with a wide range of biological activities and has been shown to possess anti-inflammatory, antioxidant and anti-angiogenic activities, and has also been shown to be effective in the treatment of a wide range of diseases such as cancer, diabetes and cardiovascular diseases.
价 格:¥电议型 号:T4632产 地:中国大陆
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T4631NSC 4810;化合物NSC 4810NSC 4810
NSC 4810 is an amide bioactive compound that has been used as a substrate for cytochrome P450 enzymes in vivo and as a substrate for acetylcholinesterase in vitro.
价 格:¥电议型 号:T4631产 地:中国大陆
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T4630NSC 404988;4-氯-N,N-二乙基苯甲酰胺NSC 404988
NSC 404988 is a benzamide-based bioactive compound used in the synthesis of compounds and the preparation of drugs, and has also been used in the study of drug metabolism and the analysis of metabolites in biological systems.
价 格:¥电议型 号:T4630产 地:中国大陆
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T4618BGG463;化合物K 0859K 0859;K 0859
BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
价 格:¥电议型 号:T4618产 地:中国大陆
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T4463Rucaparib;瑞卡帕布AG-14447|||PF-01367338|||AG014699;AG-14447|||PF-01367338|||瑞卡帕布|||AG014699
Rucaparib (PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
价 格:¥电议型 号:T4463产 地:中国大陆
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T4265AZD4635;化合物AZD4635HTL1071;HTL1071
AZD4635 (HTL1071) is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
价 格:¥电议型 号:T4265产 地:中国大陆
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T40463RelacatibRelacatibSB-462795
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib´s inhibitory effect on bone resorpti
价 格:¥电议型 号:T40463产 地:中国大陆
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T39658RMC-4630;化合物RMC-4630SHP2-IN-7|||RMC-4630;SHP2-IN-7|||RMC-4630
RMC-4630 (SHP2-IN-7) is an inhibitor of SHP2.
价 格:¥电议型 号:T39658产 地:中国大陆