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T64294Succinic acid sodium;化合物 Succinic acid sodiumSuccinic acid sodium
Succinic acid sodium is an orally active anxiolytic. Succinic acid sodium down-regulates the expression of KCNMB1 (potassium channel subunit β1) and TET1 (10-11 translocation 1). succinic acid sodium inhibits the proliferation of colonic epithelial cells in vivo. Succinic acid sodium can be used to study hypertension in pregnancy.
价 格:¥电议型 号:T64294产 地:中国大陆
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T64293SLN124;化合物 SLN124SLN124
SLN124 is a GalNac-siRNA that targets transmembrane serine protease 6 (Tmprss6) and consists of a trimeric GalNAc ligand bound to TMPRSS6-siRNA. SLN124 has the potential to be used as an siRNA agent to restore ferroregulatory expression and normalize iron homeostasis in β-depletion.
价 格:¥电议型 号:T64293产 地:中国大陆
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T64292Simvastatin acid calcium hydrate;化合物 Simvastatin acid calcium hydrateSimvastatin acid calcium hydrat
Simvastatin acid (Tenivastatin) calcium hydrate is an orally active inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid calcium hydrate also inhibits indoxyl sulfate mediated reactive oxygen species (ROS) production.
价 格:¥电议型 号:T64292产 地:中国大陆
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T64291sEH inhibitor-1;化合物 sEH inhibitor-1sEH inhibitor-1
sEH inhibitor-1 (compound TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with IC50 values of 0.4 and 5.3 nM for human and murine she, respectively.
价 格:¥电议型 号:T64291产 地:中国大陆
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T64290SCO-792;化合物 SCO-792SCO-792
SCO-792 is a potent, reversible, orally active inhibitor of enteropeptidase, which slowly dissociates from enteropeptidase in vitro and inhibits protein digestion in vivo.SCO-792 can be used to study the biological effects of enteropeptidase inhibition.
价 格:¥电议型 号:T64290产 地:中国大陆
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T6429Caffeic Acid Phenethyl Ester;咖啡酸苯乙酯Phenylethyl Caffeate|||CAPE;Phenylethyl Caffeate|||咖啡酸苯乙酯|||CAPE
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein
价 格:¥电议型 号:T6429产 地:中国大陆
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T64289Rucaparib camsylate;化合物 Rucaparib camsylateRucaparib camsylate
Rucaparib (AG014699) camsylate is an orally active inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki=1.4 nM for PARP-1. Rucaparib camsylate is an inhibitor of hexose hexaphosphate dehydrogenase (H6PD). Rucaparib camsylate has the potential to be investigated in debulking resistant prostate cancer (CRPC) studies.
价 格:¥电议型 号:T64289产 地:中国大陆
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T64288RG7800 hydrochloride;化合物 RG7800 hydrochlorideRG7800 hydrochloride
RG7800 hydrochloride is an orally active SMN2 splicing modulator that acts on SMN2 splicing (EC1.5x: 23 nM) and SMN proteins (EC1.5x: 87 nM).
价 格:¥电议型 号:T64288产 地:中国大陆
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T64287Reteplase;化合物 ReteplaseReteplase
Reteplase (BM 06.022) is a recombinant plasminogen activator consisting of the kringle 2 and protease domains of human tissue-type fibrinogen activator. Reteplase is produced by DNA technology in E. coli as a t-PA mutant, unglycosylated.
价 格:¥电议型 号:T64287产 地:中国大陆
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T64286Quinidine polygalacturonate;化合物 Quinidine polygalacturonateQuinidine polygalacturonate
Quinidine polygalacturonate is a potent, selective, orally active inhibitor of cytochrome P450db (cytochrome P450db) and a potent K+channel blocker with an IC50 value of 19.9 μM, which also induces apoptosis. Quinidine polygalacturonate is an anti-arrhythmic agent that can also be used in malaria research.
价 格:¥电议型 号:T64286产 地:中国大陆
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T64285Protease-Activated Receptor-1 antagonist 2;化合物 Protease-Activated Receptor-1 antagonist?2Protease-Ac
Protease-Activated Receptor-1 antagonist 2 is a selective, orally active protease-activated receptor-1 (PAR-1) antagonist (IC50: 7 nM). It has shown good pharmacokinetic properties and can be used for studies related to cardiovascular disease (CVD) such as atherosclerosis and restenosis.
价 格:¥电议型 号:T64285产 地:中国大陆
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T64284PROTAC CDK12/13 Degrader-1;化合物 PROTAC CDK12/13 Degrader-1PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
价 格:¥电议型 号:T64284产 地:中国大陆
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T64283Pacritinib hydrochloride;化合物 Pacritinib hydrochloridePacritinib hydrochloride
Pacritinib hydrochloride is a potent inhibitor of wild-type JAK2 (IC50: 23 nM) and the JAK2V617F mutant (IC50: 19 nM). Pacritinib hydrochloride can be used in the study of acute myeloid leukaemia (AML) and myelofibrosis (MF).
价 格:¥电议型 号:T64283产 地:中国大陆
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T64282Oxythiamine diphosphate ammonium;化合物 Oxythiamine diphosphate ammoniumOxythiamine diphosphate ammoniu
Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).
价 格:¥电议型 号:T64282产 地:中国大陆
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T64281ODN TTAGGG;化合物 ODN TTAGGGODN TTAGGG
ODN TTAGGG (A151) is an inhibitory oligonucleotide (ODN), a TLR9, AIM2 and cGAS antagonist. oDN TTAGGG competitively inhibits AIM2 inflammasome activation by DNA and inhibits cGAS activation, exhibiting immunosuppressive activity. ODN TTAGGG can be used to study autoimmune diseases such as lupus erythematosus. oDN TTAGGG sequence: 5´-T-T-A-G-G-G-T-T-A-G-G-G-G-T-T-A-G-G-G-G-G-T-T-A-G-G-G-G-G-G-3´.
价 格:¥电议型 号:T64281产 地:中国大陆
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T64280ODN 2216;化合物 ODN 2216ODN 2216
ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist that induces the production of large amounts of IFN-α and IFN-β. ODN 2216 can induce IFN-α using pDC (plasma cell-like DC) and IL-12 (p40) using DC (dendritic cells). ODN 2216 is capable of indirectly stimulating IFN-γ production by peripheral blood mononuclear cells (PBMC), mediated by IFN-α/β. ODN 2216 activates NK cells and induces IFN-γ production by TCR-triggered CD4+ T cells.
价 格:¥电议型 号:T64280产 地:中国大陆
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T6428BV6;化合物BV6BV6
BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.
价 格:¥电议型 号:T6428产 地:中国大陆
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T64279ODN 21158;化合物 ODN 21158ODN 21158
ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.
价 格:¥电议型 号:T64279产 地:中国大陆
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T64278ODN 2088;化合物 ODN 2088ODN 2088
ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.
价 格:¥电议型 号:T64278产 地:中国大陆
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T64277ODN 1585;化合物 ODN 1585ODN 1585
ODN 1585 is a potent inducer of IFN and TNFα production, a potent stimulator of NK (natural killer) and can be used as a vaccine adjuvant.ODN 1585 enhances the function of CD8+ T cells, including CD8+ T cell-mediated IFN-γ production.ODN 1585 induces regression of established melanomas in mice and has been shown to inhibit malaria in mice. ODN 1585 can be used to study acute myelogenous leukaemia (AML) and malaria.
价 格:¥电议型 号:T64277产 地:中国大陆