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T68477XL-418；化合物 XL-418XL-418
XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.
价 格：￥电议型 号：T68477产 地：中国大陆
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T68475AO-1535；化合物 AO-1535AO-1535
AO-1535 is a semisynthetic monoglycosylceramide derived from O-glycosilated sphingosine. It has been shown to inhibit superoxide production by macrophages suggesting a potential clinical application of AO 1535 in the treatment of inflammatory dermatoses.
价 格：￥电议型 号：T68475产 地：中国大陆
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T68474RWJ-58643 HCl；化合物 RWJ-58643 HClRWJ-58643 HCl
RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher doses of RWJ-58643 (300 and 600 microg) caused a late eosinophilia and preceding increases in IL-5 compared with placebo.
价 格：￥电议型 号：T68474产 地：中国大陆
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T68473WAY-255348；化合物 WAY-255348WAY-255348
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel
价 格：￥电议型 号：T68473产 地：中国大陆
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T68472Adomeglivant, (+)-；化合物 Adomeglivant, (+)-Adomeglivant, (+)-
Adomeglivant, (+)-, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes.
价 格：￥电议型 号：T68472产 地：中国大陆
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T68471(+/-)- Adomeglivant；化合物 (+/-)- Adomeglivant(+/-)- Adomeglivant
(+/-)- Adomeglivant, also known as LY2409021, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Blockade of glucagon signalling in patients with type 2 diabetes is well tolerated and results in substantial reduction of fasting and postprandial glucose with minimal hypoglycaemia, but with reversible increases in aminotransferases. Inhibition of glucagon signalling by LY2409021 is a promising potential treatm
价 格：￥电议型 号：T68471产 地：中国大陆
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T68470ASB-16165；化合物 ASB-16165ASB-16165
ASB-16165 is a phosphodiesterase 7A inhibitor that impairs proliferation of keratinocytes in vitro and in vivo. Inhibitors of PDE7A including ASB16165 might be useful for the treatment of psoriasis.
价 格：￥电议型 号：T68470产 地：中国大陆
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T6847GSK-J1；化合物GSK J1GSK J1；GSK J1
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases.
价 格：￥电议型 号：T6847产 地：中国大陆
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T68469NBI-75043；化合物 NBI-75043NBI-75043
NBI-75043 is a histamine H1 receptor antagonist, for potential use in the treatment of insomnia.
价 格：￥电议型 号：T68469产 地：中国大陆
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T68468FJ9；化合物 FJ9FJ9
FJ9 is a FZD7 inhibitor which disrupts protein-protein interaction between Frz7 and the PDZ domain of DVL, and induces apoptosis in melanoma cell line and non-small cell lung cancer cell line.
价 格：￥电议型 号：T68468产 地：中国大陆
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T68467Atorvastatin magnesium；化合物 Atorvastatin magnesiumAtorvastatin magnesium
Atorvastatin magnesium is an HMG-CoA inhibitor.
价 格：￥电议型 号：T68467产 地：中国大陆
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T68466BI-207524；化合物 BI-207524BI-207524
BI-207524 is a novel NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection.
价 格：￥电议型 号：T68466产 地：中国大陆
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T68464PABA/NO；化合物 PABA/NOPABA/NO
PABA/NO is a novel glutathione-S-transferase-p-activated nitric oxide donor, inhibiting proliferation and inducing apoptosis by targeting PI3K/AKT/mTOR and MEK/ERK pathways in hepatocellular carcinoma cells.
价 格：￥电议型 号：T68464产 地：中国大陆
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T68463BI-4834；化合物 BI-4834BI-4834
BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536.
价 格：￥电议型 号：T68463产 地：中国大陆
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T68462D-Ornithine lactam；化合物 D-Ornithine lactamD-Ornithine lactam
D-Ornithine lactam is a building block. It has been used in the synthesis of hepatitis C virus non-structural protein 5B inhibitors, as well as αVβ3 integrin receptor antagonists.
价 格：￥电议型 号：T68462产 地：中国大陆
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T6846Vesatolimod；维沙莫德GS-9620；GS-9620|||维沙莫德
Vesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.
价 格：￥电议型 号：T6846产 地：中国大陆
