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T76670hMC1R agonist 1；化合物 hMC1R agonist 1hMC1R agonist 1
hMC1R agonist 1, with an EC 50 of 3 nM, exhibits at least 300-fold higher selectivity for hMC1R compared to hMC3R (EC 50 >902 nM), hMC4R (EC 50 >915 nM), and hMC5R (EC 50 >1000 nM). This compound demonstrates potential for therapeutic applications in targeting the melanocortin family [1].
价 格：￥电议型 号：T76670产 地：中国大陆
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T76640hMCH-1R antagonist 1；化合物 hMCH-1R antagonist 1hMCH-1R antagonist 1
HMCH-1R Antagonist 1 (Compound 30) serves as an effective and selective antagonist for the human melanin-concentrating hormone receptor 1 (hMCHR1), exhibiting a K_B value of 3.6 nM. It possesses the ability to bind to hMCHR1 and hMCHR2, with IC_50 values of 65 nM and 49 nM, respectively. This compound is applicable in metabolic research [1].
价 格：￥电议型 号：T76640产 地：中国大陆
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T76090Mca-YVADAP-Lys(Dnp)-OH；化合物 Mca-YVADAP-Lys(Dnp)-OHMca-YVADAP-Lys(Dnp)-OH
Mca-YVADAP-Lys(Dnp)-OH serves as a fluorogenic substrate specifically for caspase-1 and angiotensin-converting enzyme 2 (ACE2) [1].
价 格：￥电议型 号：T76090产 地：中国大陆
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T76054SAHM1 TFA；化合物 SAHM1 TFASAHM1 TFA
SAHM1 TFA is a chemical compound that acts as a Notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. It specifically targets the protein-protein interface, effectively preventing the assembly of the Notch complex.
价 格：￥电议型 号：T76054产 地：中国大陆
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T75499Maceneolignan H；化合物 Maceneolignan HMaceneolignan H
Maceneolignan H (Compound 8), a neolignane derived from the arils of Myristica fragrans, acts as a selective CCR3 antagonist with an EC 50 value of 1.4 μM. This compound shows promise for allergic disease research [1].
价 格：￥电议型 号：T75499产 地：中国大陆
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T74030MAHMA NONOate；化合物 MAHMA NONOateMAHMA NONOate
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
价 格：￥电议型 号：T74030产 地：中国大陆
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T73566OHM1；化合物 OHM1OHM1
OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53 μM.
价 格：￥电议型 号：T73566产 地：中国大陆
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T72732Massarilactone H；化合物 Massarilactone HMassarilactone H
Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC 50 of 8.18 ?M [1] .
价 格：￥电议型 号：T72732产 地：中国大陆
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T72431Theliatinib tartrate；化合物 Theliatinib tartrateXiliertinib tartrate|||HMPL-309 tartrate|||Xiliertinib
Theliatinib (Xiliertinib) tartrate is a potent and highly selective EGFR inhibitor, displaying ATP-competitive and orally active properties. It exhibits promising efficacy with a K_i of 0.05 nM and an IC_50 of 3 nM for EGFR, alongside a specific IC_50 of 22 nM against the EGFR T790M/L858R mutant. Notably, Theliatinib demonstrates over 50-fold selectivity for EGFR compared to other kinases, underscoring its targeted action in inhibiting EGFR.
价 格：￥电议型 号：T72431产 地：中国大陆
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T72323Antiarrhythmic agent-1；化合物 Antiarrhythmic agent-1Antiarrhythmic agent-1
Antiarrhythmic agent-1 (example I), functioning as an antiarrhythmic agent and an IKr potassium channel blocker (IC 50 <1 μM), effectively inhibits cardiac arrhythmias.
价 格：￥电议型 号：T72323产 地：中国大陆
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T72260Antileishmanial agent-13；化合物 Antileishmanial agent-13Antileishmanial agent-13
Antileishmanial agent-13, a quinoline-isatin hybrid, functions as an antileishmanial agent targeting the L. Major Leishmania strain through an anti-folate mechanism. This compound exhibits potent inhibition of both the promastigote and amastigote forms, boasting IC50 values of 0.604 μM and 0.508 μM, respectively.
价 格：￥电议型 号：T72260产 地：中国大陆
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T70868HM90822；化合物 HM90822HM90822
HM90822 is a novel antagonist to the inhibitors of apoptosis (IAPs), potentiating cell death in EGFR-overexpressing non-small-cell lung cancer cells.
价 格：￥电议型 号：T70868产 地：中国大陆
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T70460HM5023507；化合物 HM5023507HM5023507
HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays and in primary human immune cells with an exquisite selectivity against other targets.
价 格：￥电议型 号：T70460产 地：中国大陆
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T70307POM2-C-HMBP；化合物 POM2-C-HMBPPOM2-C-HMBP
POM2-C-HMBP is a potent Activator of Vγ9Vδ2 T-Lymphocytes. It is also an HMBPP ananlog prodrug.
价 格：￥电议型 号：T70307产 地：中国大陆
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T7025Rehmannioside D；地黄甙 DRehmannioside D
Rehmannioside D is a carotenoid glycoside that existed in the roots of Rehmannia glutinosa.
价 格：￥电议型 号：T7025产 地：中国大陆
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T6S0109Sipeimine；西贝母碱Kashmirine|||Imperialine；Kashmirine|||西贝母碱|||Imperialine|||西贝碱
1. Sipeimine (Kashmirine) has antiasthmatic effect, on tracheal M receptor antagonist. 2. Sipeimine can make Kaba cholinergic induced contraction of tracheal strips of the dose-response curve to the right.
价 格：￥电议型 号：T6S0109产 地：中国大陆
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T69794HMN-1180；化合物 HMN-1180HMN-1180
HMN-1180 is a small molecule inhibitor of neuronal nitric oxide synthase.
价 格：￥电议型 号：T69794产 地：中国大陆
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T69749HMR-1566；化合物 HMR-1566HMR-1566
HMR-1566 is a potent and selective Iks channel blocker.
价 格：￥电议型 号：T69749产 地：中国大陆
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T6955Propafenone hydrochloride；盐酸普罗帕酮Propafenone HCl|||Arythmol|||SA-79 (hydrochloride)|||Rytmonorm|||Ryt
Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
价 格：￥电议型 号：T6955产 地：中国大陆
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T69365HMS607P03；化合物 HMS607P03HMS607P03
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP90α.
价 格：￥电议型 号：T69365产 地：中国大陆
