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T74512PROTAC eEF2K degrader-1；化合物 PROTAC eEF2K degrader-1PROTAC eEF2K degrader-1
PROTAC eEF2K degrader-1 (Compound 11l), an eEF2K-targeting PROTAC small molecule, effectively induces apoptosis in MDA-MB-231 cells through mediating eEF2K degradation [1].
价 格：￥电议型 号：T74512产 地：中国大陆
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T74439PROTAC SOS1 degrader-1；化合物 PROTAC SOS1 degrader-1PROTAC SOS1 degrader-1
PROTAC SOS1 degrader-1, a potent compound, demonstrates an effective degradation of PROTAC SOS1 with a DC50 value of 98.4 nM. It exhibits antiproliferative activity against cancer cells harboring diverse KRAS mutations and has shown an antitumor effect with low toxicity [1].
价 格：￥电议型 号：T74439产 地：中国大陆
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T74410PROTAC AR-V7 degrader-1；化合物 PROTAC AR-V7 degrader-1PROTAC AR-V7 degrader-1
PROTAC AR-V7 degrader-1 (Compound 6) is an orally bioavailable, potent, and selective degrader targeting the androgen receptor (AR) variant V7, achieving degradation with a DC50 of 0.32 ?M by directing the VHL E3 ligase to the AR DNA-binding domain (DBD). It demonstrates efficacy in the 22Rv1 cell line expressing AR-V7, with an EC50 of 0.88 ?M [1].
价 格：￥电议型 号：T74410产 地：中国大陆
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T74376PROTAC ER Degrader-10；化合物 PROTAC ER Degrader-10PROTAC ER Degrader-10
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research.
价 格：￥电议型 号：T74376产 地：中国大陆
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T74375PROTAC ERα Y537S degrader-1；化合物 PROTAC ERα Y537S degrader-1PROTAC ERα Y537S degrader-1
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] .
价 格：￥电议型 号：T74375产 地：中国大陆
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T74356PROTAC SOS1 degrader-2；化合物 PROTAC SOS1 degrader-2PROTAC SOS1 degrader-2
PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
价 格：￥电议型 号：T74356产 地：中国大陆
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T74354PROTAC Axl Degrader 2；化合物 PROTAC Axl Degrader 2PROTAC Axl Degrader 2
PROTAC Axl Degrader 2, a potent and selective PROTAC Axl degrader, demonstrates an IC50 of 1.61 ?M. It exhibits anti-proliferative and anti-migratory activities in vitro and induces mehuosis [1].
价 格：￥电议型 号：T74354产 地：中国大陆
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T74353PROTAC Axl Degrader 1；化合物 PROTAC Axl Degrader 1PROTAC Axl Degrader 1
PROTAC Axl Degrader 1 is a potent, selective degrader of PROTAC Axl, exhibiting an IC50 of 0.92 ?M. It demonstrates in vitro anti-proliferative and anti-migratory activities and induces mehuosis [1].
价 格：￥电议型 号：T74353产 地：中国大陆
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T74351PROTAC EGFR degrader 3；化合物 PROTAC EGFR degrader 3PROTAC EGFR degrader 3
PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome´s crucial role in the degradation mechanism of mutant EGFR [1].
价 格：￥电议型 号：T74351产 地：中国大陆
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T74333PROTAC EGFR degrader 2；化合物 PROTAC EGFR degrader 2PROTAC EGFR degrader 2
PROTAC EGFR degrader 2 is a potent compound with exceptional antiproliferative activity, evidenced by its IC50 of 4.0 nM, and exhibits strong EGFR degradation activity with a DC50 of 36.51 nM. It is suitable for synthesizing nitroreductase (NTR)-responsive PROTACs [1].
价 格：￥电议型 号：T74333产 地：中国大陆
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T74281FAK PROTAC B5；化合物 FAK PROTAC B5FAK PROTAC B5
Compound B5 (FAK PROTAC B5) is a FAK PROTAC degrader exhibiting potent FAK degradation and antiproliferative activities, with an IC50 of 14.9 nM. It also shows excellent plasma stability, moderate membrane permeability, and inhibits cell migration and invasion [1].
价 格：￥电议型 号：T74281产 地：中国大陆
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T74270PROTAC BRD4 Degrader-17；化合物 PROTAC BRD4 Degrader-17PROTAC BRD4 Degrader-17
PROTAC BRD4 Degrader-17 (compound 13i), a potent inhibitor, exhibits IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)), effectively reducing Cyclin B1 expression linked with G2/M phase progression and significantly inducing apoptosis in MV-4-11 cells [1].
价 格：￥电议型 号：T74270产 地：中国大陆
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T74256PROTAC BRD9-binding moiety 5；化合物 PROTAC BRD9-binding moiety 5PROTAC BRD9-binding moiety 5
PROTAC BRD9-binding moiety 5, a selective binder of BRD9 with an IC50 value of 4.20 μM, is utilized in PROTAC synthesis and exhibits antiproliferative activity against cancer cells [1].
价 格：￥电议型 号：T74256产 地：中国大陆
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T74186PROTAC-O4I2；化合物PROTAC-O4I2PROTAC-O4I2
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.
价 格：￥电议型 号：T74186产 地：中国大陆
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T74173PROTAC PARP/EGFR ligand 1；化合物 PROTAC PARP/EGFR ligand 1PROTAC PARP/EGFR ligand 1
PROTAC PARP/EGFR ligand 1 is a potent compound utilized in the creation of dual PARP-EGFR degraders through Proteolytic Targeting Chimera (PROTAC) technology [1].
价 格：￥电议型 号：T74173产 地：中国大陆
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T74138PROTAC Bcl-xL degrader-2；化合物 PROTAC Bcl-xL degrader-2PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.
价 格：￥电议型 号：T74138产 地：中国大陆
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T74137PROTAC Bcl-xL ligand-1；化合物 PROTAC Bcl-xL ligand-1PROTAC Bcl-xL ligand-1
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].
价 格：￥电议型 号：T74137产 地：中国大陆
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T74126PROTAC BRD4 Degrader-14；化合物 PROTAC BRD4 Degrader-14PROTAC BRD4 Degrader-14
PROTAC BRD4 Degrader-14, a PROTAC (Proteolysis Targeting Chimera) linked by ligands to von Hippel-Lindau and BRD4, exhibits IC50 values of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. This compound effectively degrades the BRD4 protein in PC3 prostate cancer cells [1].
价 格：￥电议型 号：T74126产 地：中国大陆
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T74125PROTAC BRD4 Degrader-12；化合物 PROTAC BRD4 Degrader-12PROTAC BRD4 Degrader-12
PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].
价 格：￥电议型 号：T74125产 地：中国大陆
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T74124PROTAC BRD4 Degrader-11；化合物 PROTAC BRD4 Degrader-11PROTAC BRD4 Degrader-11
PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies. This compound exhibits potent activity, with degradation concentration half-maximal (DC50) values of 0.23 nM and 0.38 nM for the respective conjugations [1].
价 格：￥电议型 号：T74124产 地：中国大陆
