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T80977TLR4 agonist-1 TEA;化合物 TLR4 agonist-1 TEATLR4 agonist-1 TEA
TLR4 agonist-1 (TEA, compound 17a) is a potent activator of Toll-like Receptor 4 (TLR4) and prompts the production of MIP-1β in RAW 264.7 and MM6 cells [1].
价 格:¥电议型 号:T80977产 地:中国大陆
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T80976TLR7/8 agonist 4 hydroxy-PEG6-acid;化合物 TLR7/8 agonist 4 hydroxy-PEG6-acidTLR7/8 agonist 4 hydroxy-PE
TLR7/8 agonist 4 hydroxy-PEG6-acid, a Drug-Linker Conjugate for ADCs, comprises the TLR7/8 agonist 4 and a hydroxy-PEG6-acid linker, suitable for the synthesis of antibody-drug conjugates (ADCs) [1].
价 格:¥电议型 号:T80976产 地:中国大陆
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T80863Visugromab;化合物 VisugromabCTL-002;CTL-002
Visugromab, a GDF-15 neutralizing IgG4 monoclonal antibody (mAb), demonstrates potent efficacy in treating PD-1/PD-L1 relapsed/refractory metastatic solid tumors [1].
价 格:¥电议型 号:T80863产 地:中国大陆
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T80572Exlinkibart;化合物 ExlinkibartLVGN-6051;LVGN-6051
Exlinkibart (LVGN-6051) is a humanized IgG1κ antibody that selectively targets TNFRSF9, utilizing complementarity-determining region (CDR) grafting technology for its humanization.
价 格:¥电议型 号:T80572产 地:中国大陆
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T80550N-myristoyl-RKRTLRRL;化合物 N-myristoyl-RKRTLRRLN-myristoyl-RKRTLRRL
N-myristoyl-RKRTLRRL is a compound that impedes the binding of protein kinase C (PKC) substrates and inhibits calcium (Ca2+)- and phosphatidylserine (PS)-dependent phosphorylation of histones, exhibiting an IC50 of 5 μM. Additionally, it demonstrates an inhibitory effect on histone phosphorylation with an IC50 of 80 μM [1] [2].
价 格:¥电议型 号:T80550产 地:中国大陆
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T80292BTL peptide;化合物 BTL peptideBTL peptide
BTL peptide, an antifungal peptide, exhibits activity against B. maydis, A. brassicae, A. niger, and C. personata [1].
价 格:¥电议型 号:T80292产 地:中国大陆
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T80280TLN-58;化合物 TLN-58TLN-58
TLN-58, an antimicrobial peptide, exhibits antibacterial activity against S. aureus, S. epidermidis, and group A Streptococcus. It also promotes the upregulation of inflammatory cytokine mRNAs in normal human keratinocytes and NCL-SG3 cells [1].
价 格:¥电议型 号:T80280产 地:中国大陆
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T8008816-38-Thymosin β4 (cattle) (TFA);化合物 16-38-Thymosin β4 (cattle) (TFA)16-38-Thymosin β4 (cattle) (TFA
Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].
价 格:¥电议型 号:T80088产 地:中国大陆
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T79751TLR7 agonist 16;化合物 TLR7 agonist 16TLR7 agonist 16
TLR7 agonist 16 (compound 16d) is a potent activator of TLR7 with an EC50 value of 18 nM. It effectively triggers the activation of both mouse macrophages and human peripheral blood mononuclear cells (hPBMCs) at low-nanomolar levels [1].
价 格:¥电议型 号:T79751产 地:中国大陆
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T79750TLR7 agonist 15;化合物 TLR7 agonist 15TLR7 agonist 15
TLR7 agonist 15 (compound 16b) is a potent activator of mouse macrophages and hPBMCs, demonstrating an EC50 of 18 nM. It induces robust responses at low-nanomolar concentrations [1].
价 格:¥电议型 号:T79750产 地:中国大陆
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T79749TLR7 agonist 14;化合物 TLR7 agonist 14TLR7 agonist 14
Compound 17b, a TLR7 agonist also known as TLR7 agonist 14, exhibits high potency with an EC50 of 18 nM. It effectively activates mouse macrophages and human peripheral blood mononuclear cells (hPBMCs) at low-nanomolar concentrations [1].
价 格:¥电议型 号:T79749产 地:中国大陆
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T79151TLR8 agonist 6;化合物 TLR8 agonist 6TLR8 agonist 6
Compound A, a potent TLR8 agonist, exhibits an EC50 of 0.052 ?M and promotes the production of IL-12p40 in human PBMCs with an EC50 of 0.031 ?M. This compound is applicable for research in virus resistance, infection resistance, autoimmunity, and tumor studies [1].
价 格:¥电议型 号:T79151产 地:中国大陆
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T79069TLR7/8 agonist 9;化合物 TLR7/8 agonist 9TLR7/8 agonist 9
TLR7/8 agonist 9 (Compound 25a), exhibiting EC50 values of 40 nM and 23 nM for hTLR7 and hTLR8 respectively, demonstrates anti-tumor properties and enhances the efficacy of PD-1/PD-L1 blockade treatments. This compound is utilized in cancer immunotherapy research [1].
价 格:¥电议型 号:T79069产 地:中国大陆
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T79068TLR7/8 agonist 8;化合物 TLR7/8 agonist 8TLR7/8 agonist 8
TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8). This compound has been shown to enhance the efficacy of PD-1/PD-L1 inhibitors in antitumor activity [1].
价 格:¥电议型 号:T79068产 地:中国大陆
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T78873CTL-12;化合物 CTL-12CTL-12
CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apoptotic marker Bcl-xL. By inhibiting de novo lipogenesis, CTL-12 thwarts tumor cells´ metabolic requirements and is frequently employed in breast and colorectal cancer studies [1].
价 格:¥电议型 号:T78873产 地:中国大陆
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T78872CTL-06;化合物 CTL-06CTL-06
CTL-06, a Fatty Acid Synthase (FASN) inhibitor with an IC50 of 3 μM, induces apoptosis, while CTL-12 impedes cell cycle progression in the Sub-G1/S phase and modulates apoptotic and anti-apoptotic markers by upregulating caspase-9 and Bax and downregulating Bcl-xL. Additionally, CTL-12 suppresses de novo lipogenesis, curtailing the metabolic needs of tumor cells, with utilization in breast and colorectal cancer studies [1].
价 格:¥电议型 号:T78872产 地:中国大陆
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T78454Lucifer Yellow CH dipotassium salt;化合物 Lucifer Yellow CH dipotassium saltLucifer Yellow CH dipotassi
Lucifer Yellow CH dipotassium, a high-intensity fluorescent probe featuring free hydrazyl groups, reacts with fatty aldehydes at room temperature and functions as a biological tracer for neuronal branching, regeneration, gap junction detection, and characterization, as well as selective cell ablation following aldehyde fixation. It exhibits peak excitation and emission wavelengths of 430 nm and 540 nm, respectively [1] [2].
价 格:¥电议型 号:T78454产 地:中国大陆
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T7833TLX agonist 1;化合物TLX agonist 1TLX agonist 1
TLX agonist 1 is an orphan nuclear receptor tailless (TLX, NR2E1) modulator
价 格:¥电议型 号:T7833产 地:中国大陆
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T78298Alefacept;化合物 AlefaceptLFA 3TIP|||Human LFA 3IgG fusion protein|||BG 9273;LFA 3TIP|||Human LFA 3IgG
Alefacept (BG 9273), a fusion protein combining human lymphocyte function-associated antigen 3 with immunoglobulin 1, is utilized in the research of chronic plaque psoriasis [1].
价 格:¥电议型 号:T78298产 地:中国大陆
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T78261Anti-Mouse CTLA-4 Antibody (9D9);化合物 Anti-Mouse CTLA-4 Antibody (9D9)Anti-Mouse CTLA-4 Antibody (9D9
Anti-Mouse CTLA-4 Antibody is a mouse-derived IgG2b inhibitor targeting CTLA-4 in murine systems.
价 格:¥电议型 号:T78261产 地:中国大陆